Pink1 kinase and its membrane potential (Δψ)-dependent cleavage product both localize to outer mitochondrial membrane by unique targeting mode

Journal of Biological Chemistry

Volumn 287, Issue 27, 2012, Pages 22969-22987

  Becker, Dorothea ^a   Richter, Judith ^a   Tocilescu, Maja A ^b   Przedborski, Serge ^b   Voos, Wolfgang ^a  

^a UNIVERSITY OF BONN   (Germany)

^b Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLEAVAGE PRODUCTS; CYTOPROTECTIVE EFFECTS; CYTOSOLIC; FULL-LENGTH PROTEINS; HIGH MOLECULAR WEIGHT PROTEIN; HIGHLY SENSITIVE; HYDROPHOBIC SEGMENT; IN-VITRO ASSAYS; IN-VIVO; INNER MEMBRANES; INNER MITOCHONDRIAL MEMBRANES; MEMBRANE POTENTIALS; MITOCHONDRIAL IMPORT; MUTATIONAL ANALYSIS; OUTER MEMBRANE; OUTER MITOCHONDRIAL MEMBRANES; SIGNAL SEQUENCE;

CELL MEMBRANES; CHEMICAL COMPOUNDS; ENZYMES; MEMBRANES; PROTEINS;

MITOCHONDRIA;

ENZYME PRECURSOR; MITOCHONDRIAL ENZYME; MITOCHONDRIAL PROTEIN; PHOSPHOTRANSFERASE; PINK1F53; PINK1P64; PTEN INDUCED PUTATIVE KINASE 1; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; ASSAY; CARBOXY TERMINAL SEQUENCE; CELL PROTECTION; ENZYME LOCALIZATION; GENE CONSTRUCT; IN VITRO STUDY; INNER MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL TARGETING SIGNAL; MUTATIONAL ANALYSIS; OUTER MITOCHONDRIAL MEMBRANE; PRIORITY JOURNAL; PROTEIN TRANSPORT;

ADENOSINE TRIPHOSPHATE; ANIMALS; AUTOPHAGY; CATIONS, DIVALENT; CYTOSOL; FIBROBLASTS; GENES, RECESSIVE; HELA CELLS; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MITOCHONDRIAL MEMBRANES; MOLECULAR WEIGHT; MULTIPROTEIN COMPLEXES; PARKINSON DISEASE; PROTEIN KINASES; PROTEIN STRUCTURE, TERTIARY; SULFUR ISOTOPES;

EID: 84863308390     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.365700     Document Type: Article

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