Arecoline downregulates levels of p21 and p27 through the reactive oxygen species/mTOR complex 1 pathway and may contribute to oral squamous cell carcinoma

Cancer Science

Volumn 103, Issue 7, 2012, Pages 1221-1229

  Ji, Wen Tsai ^a   Yang, Sheng Ru ^a   Chen, Jeff Yi Fu ^b   Cheng, Ya Ping ^a   Lee, Ying Ray ^c,d   Chiang, Ming Ko ^a   Chen, Hau Ren ^a  

^a NATIONAL CHUNG CHENG UNIVERSITY   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^c CHIA YI CHRISTIAN HOSPITAL   (Taiwan)

^d Min Hwei College of Health Care Management   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ARECOLINE; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PROTEIN P21; PROTEIN P27; REACTIVE OXYGEN METABOLITE;

ARTICLE; AUTOPHAGOSOME; CANCER CELL CULTURE; CONTROLLED STUDY; DNA DAMAGE; DNA REPLICATION; DOWN REGULATION; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; MOUTH SQUAMOUS CELL CARCINOMA; PRIORITY JOURNAL;

ARECOLINE; BLOTTING, WESTERN; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; CELL PROLIFERATION; CHOLINERGIC AGONISTS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASE INHIBITOR P27; DNA DAMAGE; DOWN-REGULATION; G1 PHASE CELL CYCLE CHECKPOINTS; G2 PHASE CELL CYCLE CHECKPOINTS; HUMANS; MALE; MICROSCOPY, FLUORESCENCE; MOUTH NEOPLASMS; MULTIPROTEIN COMPLEXES; REACTIVE OXYGEN SPECIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84863303696     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2012.02294.x     Document Type: Article

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