Arecoline, a major alkaloid of areca nut, inhibits p53, represses DNA repair, and triggers DNA damage response in human epithelial cells

Toxicology

Volumn 249, Issue 2-3, 2008, Pages 230-237

  Tsai, Yi Shan ^a,b   Lee, Ka Wo ^c   Huang, Jau Ling ^d   Liu, Yu Sen ^a   Juo, Suh Hang Hank ^a,b   Kuo, Wen Rei ^c   Chang, Jan Gowth ^a,b   Lin, Chang Shen ^a,b   Jong, Yuh Jyh ^a,b  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^c KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^d CHANG JUNG CHRISTIAN UNIVERSITY   (Taiwan)

Author keywords

Areca nut; Arecoline; DNA damage response; DNA repair; Oral cancer; p53

Indexed keywords

ARECOLINE; CYCLIN DEPENDENT KINASE INHIBITOR 1; HISTONE H2AX; PROTEIN P53;

ARTICLE; BETEL NUT; CARCINOGENESIS; CELL CYCLE ARREST; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DOWN REGULATION; EPITHELIUM CELL; HUMAN; HUMAN CELL; MOUTH CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ARECA; ARECOLINE; BLOTTING, WESTERN; CELL CYCLE; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELLS, CULTURED; DNA DAMAGE; DNA REPAIR; EPITHELIAL CELLS; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HISTONES; HUMANS; KB CELLS; MOUTH NEOPLASMS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR PROTEIN P53;

ARECA CATECHU; PIPER BETEL;

EID: 46449087780     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2008.05.007     Document Type: Article

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