Upregulation of p27 and its inhibition of CDK2/cyclin e activity following DNA damage by a novel platinum agent are dependent on the expression of p21

British Journal of Cancer

Volumn 95, Issue 11, 2006, Pages 1514-1524

  He, G ^a   Kuang, J ^a   Huang, Z ^a   Koomen, J ^a   Kobayashi, R ^a   Khokhar, A R ^a   Siddik, Z H ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

DNA damage; G1 phase cyclin dependent kinase; p27 regulation; Platinum complex

Indexed keywords

BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CISPLATIN; CYCLIN DEPENDENT KINASE 2; CYCLIN E; CYCLOHEXIMIDE; DIAMINOCYCLOHEXANE(DIACETATO)(DICHLORO)PLATINUM; PLATINUM DERIVATIVE; PROTEIN P21; PROTEIN P27; PROTEIN P53; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CELL CYCLE G1 PHASE; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; DRUG MECHANISM; DRUG PROTEIN BINDING; ENZYME INHIBITION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; OVARY CANCER; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN STABILITY;

ANTINEOPLASTIC AGENTS; BLOTTING, NORTHERN; CELL LINE, TUMOR; CISPLATIN; CYCLIN E; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASES; DNA DAMAGE; FEMALE; HUMANS; IMMUNOBLOTTING; IMMUNOPRECIPITATION; PLASMIDS; PROLIFERATING CELL NUCLEAR ANTIGEN; RNA, SMALL INTERFERING; TRANSFECTION; UP-REGULATION;

EID: 33845239229     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/sj.bjc.6603448     Document Type: Article

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