Dual nature of TGF-β1 in osteoblastic differentiation of human periodontal ligament cells

Journal of Hard Tissue Biology

Volumn 19, Issue 3, 2010, Pages 187-194

  Ochiai, Hiromi ^a   Yamamoto, Yasuhito ^a   Yokoyama, Akiko ^a   Yamashita, Haruto ^a   Matsuzaka, Kenichi ^a   Abe, Shinichi ^a   Azuma, Toshifumi ^a  

^a TOKYO DENTAL COLLEGE   (Japan)

Author keywords

Osteogenesis; Periodontal ligament; Phosphorylation; Smad3 protein; TGF 1

Indexed keywords

EID: 79751474784     PISSN: 13417649     EISSN: None     Source Type: Journal    
DOI: 10.2485/jhtb.19.187     Document Type: Article

References (34)

1. Zhou Y, Hutmacher DW, Sae-Lim V, Zhou Z, Woodruff M and Lim TM. Osteogenic and adipogenic induction potential of human periodontal cells. J Periodontol 79: 525-534, 2008
2. Seo BM, Miura M, Gronthos S, Bartold PM, Batouli S, Brahim J, Young M, Robey PG, Wang CY and Shi S. Investigation of multipotent postnatal stem cells from human periodontal ligament. Lancet 364: 149-155, 2004
3. Tomokiyo A, Maeda H, Fujii S, Wada N, Shima K and Akamine A. Development of a multipotent clonal human periodontal ligament cell line. Differentiation 76: 337-347, 2008
4. Janssens K, Dijke PT, Janssens S and Hul WV. Transforming growth factor-b1 to the bone. Endocr Rev 26: 743-774, 2005
5. Lee JY, Kim KH, Shin SY, Rhyu IC, Lee YM, Park YJ, Chung CP and Lee SJ. Enhanced bone formation by transforming growth factor-b1-releasing collagen/chitosan microgranules. J Biomed Mater Res A 76: 530-539, 2006
6. Zhao L, Jiang and Hantash BM. Transforming growth factor b1 induces osteogenic differentiation of murine bone marrow stromal cells. Tissue Eng Part A 16: 725-733, 2010
7. Lee KS, Hong SH and Bae SC. Both the Smad and p38 MAPK pathways play a crucial role in Runx2 expression following induction by transforming growth factor-b and bone morphogenetic protein. Oncogene 21: 7156-7163, 2002
8. Ripamonti U, Ferretti C, Teare J and Blann L. Transforming growth factor-b isoforms and the induction of bone formation. J Craniofac Surg 20: 1544-1555, 2009
9. Uematsu S, Mogi M and Deguchi T. Increase of transforming growth factor-b1 in gingival crevicular fluid during human orthodontic tooth movement. Arch Oral Biol 41: 1091-1095, 1996
10. Zhang H, Ahmad M and Gronowicz G. Effects of transforming growth factor-beta 1 (TGF-β1) on in vitro mineralization of human osteoblasts on implant materials. Biomaterials 24:2013-2020, 2003
11. Alliston T, Choy L, Ducy P, Karsenty G and Derynck R. TGF-β-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation. EMBO J 20: 2254-2272, 2001
12. Kaji H, Naito J, Sowa H, Sugimoto T and Chihara K. Smad3 differently affects osteoblast differentiation depending upon its differentiation stage. Horm Metab Res 38: 740-745, 2006
13. He WX, Niu ZY, Zhao SL, Jin WL, Gao J and Smith AJ. TGF-β activated Smad signalling leads to a Smad3-mediated down-regulation of DSPP in an odontoblast cell line. Arch Oral Biol 49: 911-918, 2004
14. Kwok S, Partridge NC, Srinivasan N, Nair SV and Selvamurugan N. Mitogen activated protein kinase-dependent inhibition of osteocalcin gene expression by transforming growth factor-b1. J Cell Biochem 106: 161-169, 2009
15. Sowa H, Kaji H, Yamaguchi T, Sugimoto T and Chihara K. Activations of ERK1/2 and JNK by transforming growth factor b negatively regulate Smad3-induced alkaline phosphatase activity and mineralization in mouse osteoblastic cells. J Biol Chem 277: 36024-36031, 2002
16. Aspenberg P, Jeppsson C, Wang JS and Boström M. Transforming growth factor beta and bone morphogenetic protein 2 for bone ingrowth: A comparison using bone chambers in rats. Bone 19: 499-503, 1996
17. Centrella M, Ji C, Casinghino S and McCarthy TL. Rapid flux in transforming growth factor-b receptors on bone cells. J Biol Chem 271: 18616-18622, 1996
18. Massagué J and Chen YG. Controlling TGF-β signaling. Genes Dev 14: 627-644, 2000
19. Shi Y and Massagué J. Mechanisms of TGF-β signaling from cell membrane to the nucleus. Cell 113: 685-700, 2003
20. Massague J and Wotton D. Transcriptional control by the TGF-β/Smad signaling system. EMBO J 19: 1745-1754, 2000
21. Yan X, Liu Z and Chen Y. Regulation of TGF-β signaling by Smad7. Acta Biochim et Biophys Sin (Shanghai) 41: 263-272, 2009
22. Miyazono K. Positive and negative regulation of TGF-β signaling. J Cell Sci 113: 1101-1109, 2000
23. Derynck R and Zhang YE. Smad-dependent and Smad-independent pathways in TGF-β family signalling. Nature 425: 577-584, 2003
24. Nagata S, Nozaki T, Ohura K and Daito M. Analysis of gene expression during differentiation induction of normal human periodontal ligament cells into osteoblast lineage. J Oral Tissue Engin 6: 88-96, 2008
25. Zimmermann G, Henle P, Küsswetter M, Moghaddam A, Wentzensen A, Richter W and Weiss S. TGF-β1 as a marker of delayed fracture healing. Bone 36: 779-785, 2005
26. Carrington JL, Roberts AB, Flanders KC, Roche NS and Reddi AH. Accumulation, localization, and compartmentation of transforming growth factor b during endochondral bone development. J Cell Biol 107: 1969-1975, 1988
27. Devescovi V, Leonardi E, Ciapetti G and Cenni E. Growth factors in bone repair. Chir Organi Mov 92: 161-168, 2008
28. Sumner DR, Turner TM, Purchio AF, Gombotz WR, Urban RM and Galante JO. Enhancement of bone ingrowth by transforming growth factor-b. J Bone Joint Surg Am 77: 1135-1147, 1995
29. Chaudhury A and Howe PH. The tale of transforming growth factor-beta (TGFβ) signaling: A soigné enigma. IUBMB Life 61: 929-939, 2009
30. Sowa H, Kaji H, Yamaguchi T, Sugimoto T and Chihara K. Smad3 promotes alkaline phosphatase activity and mineralization of osteoblastic MC3T3-E1 cells. J Bone Miner Res 17: 1190-1199, 2002
31. Borton AJ, Frederick JP, Datto MB, Wang X and Weinstein RS. The loss of Smad3 results in a lower rate of bone formation and osteopenia through dysregulation of osteoblast differentiation and apoptosis. J Bone Miner Res 16: 1754-1764, 2001
32. Miyazono A, Yamada A, Morimura N, Takami M, Suzuki D, Kobayashi M, Tezuka K, Yamamoto M and Kamijo R. TGF-β suppresses POEM expression through ERK1/2 and JNK in osteoblasts. FEBS Lett 581: 5321-5326, 2007
33. Moustakas A and Heldin CH. Non-Smad TGF-β signals. J Cell Sci 118: 3573-3584, 2005
34. Rahimi RA and Leof EB. TGF-β signaling: A tale of two responses. J Cell Biochem 102: 593-608, 2007