TGF-β suppresses POEM expression through ERK1/2 and JNK in osteoblasts

FEBS Letters

Volumn 581, Issue 27, 2007, Pages 5321-5326

  Miyazono, Agasa ^a   Yamada, Atsushi ^a   Morimura, Naoko ^b   Takami, Masamichi ^a   Suzuki, Dai ^a   Kobayashi, Makoto ^a   Tezuka, Ken ichi ^c   Yamamoto, Matsuo ^a   Kamijo, Ryutaro ^a  

^a SHOWA UNIVERSITY   (Japan)

^b RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

^c GIFU UNIVERSITY   (Japan)

Author keywords

ERK1 2; JNK; Osteoblasts; POEM; TGF

Indexed keywords

CELL ADHESION MOLECULE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NEPHRONECTIN; PROTEIN POEM; SCLEROPROTEIN; STRESS ACTIVATED PROTEIN KINASE; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BONE DEVELOPMENT; ENZYME ACTIVATION; GENE CONTROL; HUMAN; KIDNEY DEVELOPMENT; MOUSE; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION;

3T3 CELLS; ANIMALS; BASE SEQUENCE; BONE MORPHOGENETIC PROTEINS; CELLS, CULTURED; DOWN-REGULATION; EXTRACELLULAR MATRIX PROTEINS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE SIGNALING SYSTEM; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MODELS, BIOLOGICAL; OSTEOBLASTS; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; RECOMBINANT PROTEINS; RNA, MESSENGER; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

EID: 35548981268     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2007.10.021     Document Type: Article

References (34)

1. Morimura N., Tezuka Y., Watanabe N., Yasuda M., Miyatani S., Hozumi N., and Tezuka Ki K. Molecular cloning of POEM: a novel adhesion molecule that interacts with α8β1 integrin. J. Biol. Chem. 276 (2001) 42172-42181
2. Brandenberger R., Schmidt A., Linton J., Wang D., Backus C., Denda S., Muller U., and Reichardt L.F. Identification and characterization of a novel extracellular matrix protein nephronectin that is associated with integrin α8β1 in the embryonic kidney. J Cell Biol. 154 (2001) 447-458
3. Osada A., et al. Expression of MAEG, a novel basement membrane protein, in mouse hair follicle morphogenesis. Exp. Cell Res. 303 (2005) 148-159
4. Smas C.M., and Sul H.S. Pref-1, a protein containing EGF-like repeats, inhibits adipocyte differentiation. Cell 73 (1993) 725-734
5. Hidai C., et al. Cloning and characterization of developmental endothelial locus-1: an embryonic endothelial cell protein that binds the αvβ3 integrin receptor. Gene Dev. 12 (1998) 21-33
6. Nakamura T., et al. DANCE, a novel secreted RGD protein expressed in developing, atherosclerotic, and balloon-injured arteries. J. Biol. Chem. 274 (1999) 22476-22483
7. Lecka-Czernik B., Lumpkin Jr. C.K., and Goldstein S. An overexpressed gene transcript in senescent and quiescent human fibroblasts encoding a novel protein in the epidermal growth factor-like repeat family stimulates DNA synthesis. Mol. Cell Biol. 15 (1995) 120-128
8. Singson A., Mercer K.B., and L'Hernault S.W. The C. elegans spe-9 gene encodes a sperm transmembrane protein that contains EGF-like repeats and is required for fertilization. Cell 93 (1998) 71-79
9. Linton J.M., Martin G.R., and Reichardt L.F. The ECM protein nephronectin promotes kidney development via integrin α8β1-mediated stimulation of Gdnf expression. Development 134 (2007) 2501-2509
10. Robey P.G., et al. Osteoblasts synthesize and respond to transforming growth factor-β (TGF-β) type in vitro. J. Cell Biol. 105 (1987) 457-463
11. Bonewald L.F., and Dallas S.L. Role of active and latent transforming growth factor-β in bone formation. J. Cell Biochem. 55 (1994) 350-357
12. Centrella M., Horowitz M.C., Wozney J.M., and McCarthy T.L. Transforming growth factor-β gene family members and bone. Endocr. Rev. 15 (1994) 27-39
13. Heldin C.H., Miyazono K., and ten Dijke P. TGF-β signaling from cell membrane to nucleus through SMAD proteins. Nature 390 (1997) 465-471
14. Massague J., and Wotton D. Transcriptional control by the TGF-β/Smad signaling system. EMBO J. 19 (2000) 1745-1754
15. Derynck R., and Zhang Y.E. Smad-dependent and Smad-independent pathways in TGF-β family signaling. Nature 425 (2003) 577-584
16. 3 in osteoclast differentiation and function. Method Enzymol. 282 (1997) 223-235
17. Sudo H., Kodama H.A., Amagai Y., Yamamoto S., and Kasai S. In vitro differentiation and calcification in a new clonal osteogenic cell line derived from newborn mouse calvaria. J. Cell Biol. 96 (1983) 191-198
18. Urist M.R. Bone: formation by autoinduction. Science 150 (1965) 893-899
19. Rickard D.J., Sullivan T.A., Shenker B.J., Leboy P.S., and Kazhdan I. Induction of rapid osteoblast differentiation in rat bone marrow stromal cell cultures by dexamethasone and BMP-2. Dev. Biol. 161 (1994) 218-228
20. Thies R.S., Bauduy M., Ashton B.A., Kurtzberg L., Wozney J.M., and Rosen V. Recombinant human bone morphogenetic protein-2 induces osteoblastic differentiation in W-20-17 stromal cells. Endocrinology 130 (1992) 1318-1324
21. Amedee J., Bareille R., Rouais F., Cunningham N., Reddi H., and Harmand M.F. Osteogenin (bone morphogenic protein 3) inhibits proliferation and stimulates differentiation of osteoprogenitors in human bone marrow. Differentiation 58 (1994) 157-164
22. Harada H., Tagashira S., Fujiwara M., Ogawa S., Katsumata T., Yamaguchi A., Komori T., and Nakatsuka M. Cbfa1 isoforms exert functional differences in osteoblast differentiation. J. Biol. Chem. 274 (1999) 6972-6978
23. Ogata Y., Niisato N., Furuyama S., Cheifetz S., Kim R.H., Sugiya H., and Sodek J. Transforming growth factor-β 1 regulation of bone sialoprotein gene transcription: identification of a TGF-β activation element in the rat BSP gene promoter. J. Cell Biochem. 65 (1997) 501-512
24. Desbois C., Hogue D.A., and Karsenty G. The mouse osteocalcin gene cluster contains three genes with two separate spatial and temporal patterns of expression. J. Biol. Chem. 269 (1994) 1183-1190
25. Gellibert F., et al. Identification of 1,5-naphthyridine derivatives as a novel series of potent and selective TGF-β type I receptor inhibitors. J. Med. Chem. 47 (2004) 4494-4506
26. Mulder K.M. Role of Ras and Mapks in TGF-β signaling. Cytokine Growth Factor Rev. 11 (2000) 23-35
27. Sowa H., Kaji H., Yamaguchi T., Sugimoto T., and Chihara K. Activations of ERK1/2 and JNK by transforming growth factor-β negatively regulate Smad3-induced alkaline phosphatase activity and mineralization in mouse osteoblastic cells. J. Biol. Chem. 277 (2002) 36024-36031
28. Leask A., and Abraham D.J. TGF-β signaling and the fibrotic response. FASEB J. 18 (2004) 816-827
29. Heino J., Ignotz R.A., Hemler M.E., Crouse C., and Massague J. Regulation of cell adhesion receptors by transforming growth factor-β. Concomitant regulation of integrins that share a common beta 1 subunit. J. Biol. Chem. 264 (1989) 380-388
30. Sporn M.B., and Roberts A.B. Transforming growth factor-β: recent progress and new challenges. J. Cell Biol. 119 (1992) 1017-1021
31. Miyazono K., Ten Dijke P., Ichijo H., and Heldin C.H. Receptors for transforming growth factor-β. Adv. Immunol. 55 (1994) 181-220
32. Verrecchia F., Tacheau C., Schorpp-Kistner M., Angel P., and Mauviel A. Induction of the AP-1 members c-Jun and JunB by TGF-β/Smad suppresses early Smad-driven gene activation. Oncogene 20 (2001) 2205-2211
33. Alliston T., Choy L., Ducy P., Karsenty G., and Derynck R. TGF-β-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation. EMBO J. 20 (2001) 2254-2272
34. Ducy P., Zhang R., Geoffroy V., Ridall A.L., and Karsenty G. Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell 89 (1997) 747-754