Deletion of mouse Porcn blocks Wnt ligand secretion and reveals an ectodermal etiology of human focal dermal hypoplasia/Goltz syndrome

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 31, 2011, Pages 12752-12757

  Barrott, Jared J ^a   Cash, Gabriela M ^a   Smith, Aaron P ^b   Barrow, Jeffery R ^b   Murtaugh, L Charles ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b BRIGHAM YOUNG UNIVERSITY   (United States)

Author keywords

Dermis; Epidermis; Hair follicle; Skeletal development

Indexed keywords

PEPTIDES AND PROTEINS; PORCN PROTEIN; UNCLASSIFIED DRUG; WNT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; FEMALE; GENE ACTIVITY; GENE DELETION; GOLTZ SYNDROME; LIMB DISEASE; MESODERM; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SKIN DISEASE;

AMINO ACID SEQUENCE; ANIMALS; BETA CATENIN; BLOTTING, WESTERN; BODY PATTERNING; CELLS, CULTURED; DISEASE MODELS, ANIMAL; ECTODERM; EMBRYO, MAMMALIAN; FEMALE; FIBROBLASTS; FOCAL DERMAL HYPOPLASIA; GENE DELETION; HUMANS; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; TCF TRANSCRIPTION FACTORS; WNT PROTEINS; WNT1 PROTEIN;

EID: 79961237652     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1006437108     Document Type: Article

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