Dual regulation by ethanol of the inhibitory effects of ketamine on spinal NMDA-induced pressor responses in rats

Journal of Biomedical Science

Volumn 19, Issue 1, 2012, Pages

  Keng, Nien Tzu ^a,b   Lin, Hsun Hsun ^a   Lin, Huei Ru ^a   Hsieh, Wei Kung ^c   Lai, Chih Chia ^a  

^a TZU CHI UNIVERSITY   (Taiwan)

^b TZU CHI COLLEGE OF TECHNOLOGY   (Taiwan)

^c National Taitung Junior College   (Taiwan)

Author keywords

alcohol; ketamine; NMDA receptor; phosphorylation; PKA; sympathetic neuron

Indexed keywords

ALCOHOL; CYCLIC AMP DEPENDENT PROTEIN KINASE; KETAMINE; N METHYL DEXTRO ASPARTIC ACID; PHOSPHOSERINE; SERINE; ADENOSINE 3',5' PHOSPHOROTHIOATE; ADENOSINE-3',5'-CYCLIC PHOSPHOROTHIOATE; CYCLIC AMP; DRUG DERIVATIVE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYLASPARTIC ACID; NUCLEOTIDE;

AMINO ACID BLOOD LEVEL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG INHIBITION; DRUG POTENTIATION; MALE; NONHUMAN; PRESSOR RESPONSE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; WESTERN BLOTTING; ANIMAL; DRUG ANTAGONISM; DRUG EFFECT; INTRASPINAL DRUG ADMINISTRATION; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; SPINAL CORD; SPRAGUE DAWLEY RAT; TIME;

RATTUS;

ANIMALS; BLOTTING, WESTERN; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ETHANOL; INJECTIONS, SPINAL; KETAMINE; MALE; N-METHYLASPARTATE; PHOSPHORYLATION; PHOSPHOSERINE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; SPINAL CORD; THIONUCLEOTIDES; TIME FACTORS;

EID: 84863288491     PISSN: 10217770     EISSN: 14230127     Source Type: Journal    
DOI: 10.1186/1423-0127-19-1122300389     Document Type: Article

References (45)

1. Nagy J: Alcohol Related Changes in Regulation of NMDA Receptor Functions. Curr Neuropharmacol 2008, 6:39-54.
2. Krystal JH, Petrakis IL, Mason G, Trevisan L, D'Souza DC: N-methyl-Daspartate glutamate receptors and alcoholism: reward, dependence, treatment, and vulnerability. Pharmacol Ther 2003, 99:79-94.
3. Davis KM, Wu JY: Role of glutamatergic and GABAergic systems in alcoholism. J Biomed Sci 2001, 8:7-19. (Pubitemid 32098481)
4. Lovinger DM, White G, Weight FF: Ethanol inhibits NMDA-activated ion current in hippocampal neurons. Science 1989, 243:1721-1724. (Pubitemid 19106970)
5. Woodward JJ, Ron D, Winder D, Roberto M: From blue states to up states: a regional view of NMDA-ethanol interactions. Alcohol Clin Exp Res 2006, 30:359-367. (Pubitemid 43341386)
6. Spanagel R: Alcoholism: a systems approach from molecular physiology to addictive behavior. Physiol Rev 2009, 89:649-705.
7. Cull-Candy S, Brickley S, Farrant M: NMDA receptor subunits: diversity, development and disease. Curr Opin Neurobiol 2001, 11:327-335. (Pubitemid 32524098)
8. Ron D: Signaling cascades regulating NMDA receptor sensitivity to ethanol. Neuroscientist 2004, 10:325-336.
9. Dampney RA: Functional organization of central pathways regulating the cardiovascular system. Physiol Rev 1994, 74:323-364.
10. Lin HH, Hsieh WK, Shiu JY, Chiu TH, Lai CC: Inhibition by ethanol of NMDA-induced responses and acute tolerance to the inhibition in rat sympathetic preganglionic neurons in vitro and in vivo. Br J Pharmacol 2003, 140:955-963. (Pubitemid 37464079)
11. Hsieh WK, Lin HH, Lai CC: Involvement of protein kinase C and Src tyrosine kinase in acute tolerance to ethanol inhibition of spinal NMDA-induced pressor responses in rats. Br J Pharmacol 2009, 158:806-818.
12. Lin HR, Lin HL, Lee SF, Liu C, Lua AC: A fast screening procedure for ketamine and metabolites in urine samples with tandem mass spectrometry. J Anal Toxicol 2010, 34:149-154.
13. Lin HH, Chen CH, Hsieh WK, Chiu TH, Lai CC: Hydrogen peroxide increases the activity of rat sympathetic preganglionic neurons in vivo and in vitro. Neuroscience 2003, 121:641-647. (Pubitemid 38367503)
14. Chiu HY, Lin HH, Lai CC: Cocaine- and amphetamine-regulated transcript (CART) peptide activates ERK pathways via NMDA receptors in rat spinal cord dorsal horn in an age-dependent manner. Regul Pept 2010, 164:90-96.
15. Farber NB, Olney JW: Drugs of abuse that cause developing neurons to commit suicide. Brain Res Dev Brain Res 2003, 147:37-45. (Pubitemid 38114695)
16. Ikonomidou C, Bosch F, Miksa M, Bittigau P, Vockler J, Dikranian K, Tenkova TI, Stefovska V, Turski L, Olney JW: Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain. Science 1999, 283:70-74. (Pubitemid 29044848)
17. Lua AC, Lin HR, Tseng YT, Hu AR, Yeh PC: Profiles of urine samples from participants at rave party in Taiwan: prevalence of ketamine and MDMA abuse. Forensic Sci Int 2003, 136:47-51. (Pubitemid 37101293)
18. Moore KA, Kilbane EM, Jones R, Kunsman GW, Levine B, Smith M: Tissue distribution of ketamine in a mixed drug fatality. J Forensic Sci 1997, 42:1183-1185. (Pubitemid 27495848)
19. Licata M, Pierini G, Popoli G: A fatal ketamine poisoning. J Forensic Sci 1994, 39:1314-1320.
20. Orser BA, Pennefather PS, MacDonald JF: Multiple mechanisms of ketamine blockade of N-methyl-D-aspartate receptors. Anesthesiology 1997, 86:903-917. (Pubitemid 27174731)
21. Allgaier C: Ethanol sensitivity of NMDA receptors. Neurochem Int 2002, 41:377-382.
22. Ren H, Honse Y, Peoples RW: A site of alcohol action in the fourth membrane-associated domain of the N-methyl-D-aspartate receptor. J Biol Chem 2003, 278:48815-48820. (Pubitemid 41079524)
23. Ronald KM, Mirshahi T, Woodward JJ: Ethanol inhibition of N-methyl-Daspartate receptors is reduced by site-directed mutagenesis of a transmembrane domain phenylalanine residue. J Biol Chem 2001, 276:44729-44735.
24. Peoples RW, Stewart RR: Alcohols inhibit N-methyl-D-aspartate receptors via a site exposed to the extracellular environment. Neuropharmacology 2000, 39:1681-1691. (Pubitemid 30398473)
25. Smothers CT, Woodward JJ: Effects of amino acid substitutions in transmembrane domains of the NR1 subunit on the ethanol inhibition of recombinant N-methyl-D-aspartate receptors. Alcohol Clin Exp Res 2006, 30:523-530.
26. Rondon ES, Vieira AS, Valadao CA, Parada CA: The improvement of the anti-hyperalgesic effect of ketamine and of its isomers by the administration of ifenprodil. Eur J Pharmacol 2010, 647:84-89.
27. Chen BS, Roche KW: Regulation of NMDA receptors by phosphorylation. Neuropharmacology 2007, 53:362-368.
28. Newton PM, Messing RO: Intracellular signaling pathways that regulate behavioral responses to ethanol. Pharmacol Ther 2006, 109:227-237. (Pubitemid 41740823)
29. Pandey SC: Neuronal signaling systems and ethanol dependence. Mol Neurobiol 1998, 17:1-15.
30. Anders DL, Blevins T, Sutton G, Swope S, Chandler LJ, Woodward JJ: Fyn tyrosine kinase reduces the ethanol inhibition of recombinant NR1/NR2A but not NR1/NR2B NMDA receptors expressed in HEK 293 cells. J Neurochem 1999, 72:1389-1393. (Pubitemid 29140807)
31. Maldve RE, Zhang TA, Ferrani-Kile K, Schreiber SS, Lippmann MJ, Snyder GL, Fienberg AA, Leslie SW, Gonzales RA, Morrisett RA: DARPP-32 and regulation of the ethanol sensitivity of NMDA receptors in the nucleus accumbens. Nat Neurosci 2002, 5:641-648. (Pubitemid 34742979)
32. Snell LD, Tabakoff B, Hoffman PL: Involvement of protein kinase C in ethanol-induced inhibition of NMDA receptor function in cerebellar granule cells. Alcohol Clin Exp Res 1994, 18:81-85. (Pubitemid 24136761)
33. Yu MC, Chen JH, Lai CY, Han CY, Ko WC: Luteolin, a non-selective competitive inhibitor of phosphodiesterases 1-5, displaced [3H]-rolipram from high-affinity rolipram binding sites and reversed xylazine/ ketamine-induced anesthesia. Eur J Pharmacol 2010, 627:269-275.
34. Stubbs CD, Slater SJ: Ethanol and protein kinase C. Alcohol Clin Exp Res 1999, 23:1552-1560. (Pubitemid 29468454)
35. Das J, Pany S, Rahman GM, Slater SJ: PKC epsilon has an alcohol-binding site in its second cysteine-rich regulatory domain. Biochem J 2009, 421:405-413.
36. Grosshans DR, Clayton DA, Coultrap SJ, Browning MD: LTP leads to rapid surface expression of NMDA but not AMPA receptors in adult rat CA1. Nat Neurosci 2002, 5:27-33. (Pubitemid 34038779)
37. Alvestad RM, Grosshans DR, Coultrap SJ, Nakazawa T, Yamamoto T, Browning MD: Tyrosine dephosphorylation and ethanol inhibition of N-methyl- D-aspartate receptor function. J Biol Chem 2003, 278:11020-11025. (Pubitemid 36792651)
38. Kumar S, Porcu P, Werner DF, Matthews DB, Diaz-Granados JL, Helfand RS, Morrow AL: The role of GABA(A) receptors in the acute and chronic effects of ethanol: a decade of progress. Psychopharmacology (Berl) 2009, 205:529-564.
39. Schummers J, Browning MD: Evidence for a role for GABA(A) and NMDA receptors in ethanol inhibition of long-term potentiation. Brain Res Mol Brain Res 2001, 94:9-14. (Pubitemid 32964741)
40. Parry CD, Patra J, Rehm J: Alcohol consumption and non-communicable diseases: epidemiology and policy implications. Addiction 2011, 106:1718-1724.
41. Klatsky AL: Alcohol, coronary disease, and hypertension. Annu Rev Med 1996, 47:149-160.
42. Puddey IB, Beilin LJ: Alcohol is bad for blood pressure. Clin Exp Pharmacol Physiol 2006, 33:847-852. (Pubitemid 44215142)
43. Zilkens RR, Burke V, Hodgson JM, Barden A, Beilin LJ, Puddey IB: Red wine and beer elevate blood pressure in normotensive men. Hypertension 2005, 45:874-879. (Pubitemid 40628931)
44. Abdel-Rahman AA, Wooles WR: Ethanol-induced hypertension involves impairment of baroreceptors. Hypertension 1987, 10:67-73. (Pubitemid 17104014)
45. Hering D, Kucharska W, Kara T, Somers VK, Narkiewicz K: Potentiated sympathetic and hemodynamic responses to alcohol in hypertensive vs. normotensive individuals. J Hypertens 2011, 29:537-541.