Involvement of protein kinase C and Src tyrosine kinase in acute tolerance to ethanol inhibition of spinal NMDA-induced pressor responses in rats

British Journal of Pharmacology

Volumn 158, Issue 3, 2009, Pages 806-818

  Hsieh, W K ^a   Lin, H H ^a   Lai, C C ^a  

^a TZU CHI UNIVERSITY   (Taiwan)

Author keywords

Alcohol; Ion channel regulation; NMDA receptor; Protein kinase C; Src tyrosine kinases; Sympathetic activity; Tolerance

Indexed keywords

4 AMINO 7 TERT BUTYL 5 (4 CHLOROPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; ALCOHOL; CHELERYTHRINE; KT 5720; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; PHOSPHOSERINE; PHOSPHOTYROSINE; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR;

ALCOHOL BLOOD LEVEL; ALCOHOL TOLERANCE; ANIMAL EXPERIMENT; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; DOSE RESPONSE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; IN VITRO STUDY; IN VIVO STUDY; LONG TERM EXPOSURE; MALE; NERVE CELL; NONHUMAN; PHARMACOLOGICAL BLOCKING; PRESSOR RESPONSE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SPINAL CORD; WESTERN BLOTTING;

ANIMALS; BLOOD PRESSURE; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DRUG TOLERANCE; ENZYME ACTIVATION; ETHANOL; INJECTIONS, SPINAL; MALE; N-METHYLASPARTATE; PHOSPHORYLATION; PHOSPHOSERINE; PHOSPHOTYROSINE; PROTEIN KINASE C; PROTEIN SUBUNITS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; SPINAL CORD; SRC-FAMILY KINASES;

EID: 70350060168     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2009.00364.x     Document Type: Article

References (32)

1. Abdel-Rahman AA, Wooles WR (1987). Ethanol-induced hypertension involves impairment of baroreceptors. Hypertension 10 : 67 73.
2. Alexander SP, Mathie A, Peters JA (2008). Guide to Receptors and Channels (GRAC), 3rd edition. Br J Pharmacol 153 (Suppl. 2 S1 209.
3. Alvestad RM, Grosshans DR, Coultrap SJ, Nakazawa T, Yamamoto T, Browning MD (2003). Tyrosine dephosphorylation and ethanol inhibition of N-methyl-D-aspartate receptor function. J Biol Chem 278 : 11020 11025.
4. Chen BS, Roche KW (2007). Regulation of NMDA receptors by phosphorylation. Neuropharmacology 53 : 362 368.
5. Cull-Candy S, Brickley S, Farrant M (2001). NMDA receptor subunits: diversity, development and disease. Curr Opin Neurobiol 11 : 327 335.
6. Dampney RA (1994). Functional organization of central pathways regulating the cardiovascular system. Physiol Rev 74 : 323 364.
7. Deuchars SA, Morrison SF, Gilbey MP (1995). Medullary-evoked EPSPs in neonatal rat sympathetic preganglionic neurones in vitro. J Physiol (Lond) 487 : 453 463.
8. Grosshans DR, Browning MD (2001). Protein kinase C activation induces tyrosine phosphorylation of the NR2A and NR2B subunits of the NMDA receptor. J Neurochem 76 : 737 744.
9. Inokuchi H, Yoshimura M, Yamada S, Polosa C, Nishi S (1992). Fast excitatory postsynaptic potentials and the responses to excitant amino acids of sympathetic preganglionic neurons in the slice of the cat spinal cord. Neuroscience 46 : 657 667.
10. Lai C-C, Chang M-C, Lin HH (2004). Acute tolerance to ethanol inhibition of NMDA-induced responses in rat rostral ventrolateral medulla neurons. J Biomed Sci 11 : 482 492.
11. Lan JY, Skeberdis VA, Jover T, Grooms SY, Lin Y, Araneda RC et al. (2001). Protein kinase C modulates NMDA receptor trafficking and gating. Nat Neurosci 4 : 382 390.
12. Liao GY, Wagner DA, Hsu MH, Leonard JP (2001). Evidence for direct protein kinase-C mediated modulation of N-methyl-D-aspartate receptor current. Mol Pharmacol 59 : 960 964.
13. Lin HH, Chen C-H, Hsieh W-K, Chiu TH, Lai C-C (2003a). Hydrogen peroxide increases the activity of rat sympathetic preganglionic neurons in vivo and in vitro. Neuroscience 121 : 641 647.
14. Lin HH, Hsieh W-K, Shiu J-Y, Chiu TH, Lai C-C (2003b). Inhibition by ethanol of NMDA-induced responses and acute tolerance to the inhibition in rat sympathetic preganglionic neurons in vitro and in vivo. Br J Pharmacol 140 : 955 963.
15. Lin HH, Chang SJ, Shie HJ, Lai CC (2006). Ethanol inhibition of NMDA-induced responses and acute tolerance to the inhibition in rat rostral ventrolateral medulla in vivo: involvement of cAMP-dependent protein kinases. Neuropharmacology 51 : 747 755.
16. Lu WY, Xiong ZG, Lei S, Orser BA, Dudek E, Browning MD et al. (1999). G-protein-coupled receptors act via protein kinase C and Src to regulate NMDA receptors. Nat Neurosci 2 : 331 338.
17. Maldve RE, Zhang TA, Ferrani-Kile K, Schreiber SS, Lippmann MJ, Snyder GL et al. (2002). DARPP-32 and regulation of the ethanol sensitivity of NMDA receptors in the nucleus accumbens. Nat Neurosci 5 : 641 648.
18. Malkmus SA, Yaksh TL (2004). Intrathecal catheterization and drug delivery in the rat. Methods Mol Med 99 : 109 121.
19. Miyakawa T, Yagi T, Kitazawa H, Yasuda M, Kawai N, Tsuboi K et al. (1997). Fyn-kinase as a determinant of ethanol sensitivity: relation to NMDA-receptor function. Science 278 : 698 701.
20. Newton PM, Messing RO (2006). Intracellular signaling pathways that regulate behavioral responses to ethanol. Pharmacol Ther 109 : 227 237.
21. Nishio H, Matsui K, Tsuji H, Tamura A, Suzuki K (2001). Possible involvement of Fyn kinase in ethanol-stimulated Cas tyrosine phosphorylation in rat cerebellum and cerebral cortex. J Neurochem 76 : 1073 1079.
22. Pandey SC (1998). Neuronal signaling systems and ethanol dependence. Mol Neurobiol 17 : 1 15.
23. Puddey IB, Beilin LJ (2006). Alcohol is bad for blood pressure. Clin Exp Pharmacol Physiol 33 : 847 852.
24. Randin D, Vollenweider P, Tappy L, Jequier E, Nicod P, Scherrer U (1995). Suppression of alcohol-induced hypertension by dexamethasone. N Engl J Med 332 : 1733 1737.
25. Salter MW (1998). Src, N-methyl-D-aspartate (NMDA) receptors, and synaptic plasticity. Biochem Pharmacol 56 : 789 798.
26. Shpilenya LS, Muzychenko AP, Gasbarrini G, Addolorato G (2002). Metadoxine in acute alcohol intoxication: a double-blind, randomized, placebo-controlled study. Alcohol Clin Exp Res 26 : 340 346.
27. Snell LD, Tabakoff B, Hoffman PL (1994). Involvement of protein kinase C in ethanol-induced inhibition of NMDA receptor function in cerebellar granule cells. Alcohol Clin Exp Res 18 : 81 85.
28. Stubbs CD, Slater SJ (1999). Ethanol and protein kinase C. Alcohol Clin Exp Res 23 : 1552 1560.
29. Waxman EA, Lynch DR (2005). N-methyl-D-aspartate receptor subtypes: multiple roles in excitotoxicity and neurological disease. Neuroscientist 11 : 37 49.
30. Westphal RS, Tavalin SJ, Lin JW, Alto NM, Fraser ID, Langeberg LK et al. (1999). Regulation of NMDA receptors by an associated phosphatase-kinase signaling complex. Science 285 : 93 96.
31. Woodward JJ (2000). Ethanol and NMDA receptor signaling. Crit Rev Neurobiol 14 : 69 89.
32. Yaka R, Phamluong K, Ron D (2003). Scaffolding of Fyn kinase to the NMDA receptor determines brain region sensitivity to ethanol. J Neurosci 23 : 3623 3632.