Geldanamycin derivative ameliorates high fat diet-induced renal failure in diabetes

PLoS ONE

Volumn 7, Issue 3, 2012, Pages

  Zhang, Hong Mei ^a,b   Dang, Howard ^b   Kamat, Amrita ^b,c   Yeh, Chih Ko ^b,c   Zhang, Bin Xian ^b,c  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^c SOUTH TEXAS VETERANS HEALTH CARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 NITROTYROSINE; ALVESPIMYCIN; 17-(DIMETHYLAMINOETHYLAMINO)-17-DEMETHOXYGELDANAMYCIN; 3-NITROTYROSINE; BENZOQUINONE DERIVATIVE; CALCIUM; DRUG DERIVATIVE; HEAT SHOCK PROTEIN 90; MACROCYCLIC LACTAM; TYROSINE;

ALBUMINURIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANURIA; ARTICLE; CALCIUM TRANSPORT; DISEASE COURSE; DISEASE EXACERBATION; DRUG EFFICACY; DRUG MECHANISM; KIDNEY FAILURE; KIDNEY FUNCTION; KIDNEY STRUCTURE; LIPID DIET; MITOCHONDRION; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OLIGURIA; TREATMENT RESPONSE; URINE VOLUME; ANIMAL; DIABETIC NEPHROPATHY; DISEASE MODEL; DRUG ANTAGONISM; DRUG EFFECT; GLOMERULUS; KAPLAN MEIER METHOD; KIDNEY FUNCTION TEST; KIDNEY TUBULE; MALE; METABOLISM; MORTALITY; MOUSE MUTANT; PATHOLOGY;

ANIMALIA; MUS; RODENTIA;

ANIMALS; BENZOQUINONES; CALCIUM; DIABETIC NEPHROPATHIES; DIET, HIGH-FAT; DISEASE MODELS, ANIMAL; HSP90 HEAT-SHOCK PROTEINS; KAPLAN-MEIER ESTIMATE; KIDNEY FUNCTION TESTS; KIDNEY GLOMERULUS; KIDNEY TUBULES; LACTAMS, MACROCYCLIC; MALE; MICE; MICE, KNOCKOUT; MITOCHONDRIA; RENAL INSUFFICIENCY; TYROSINE;

EID: 84863284793     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0032746     Document Type: Article

References (57)

1. Ismail-Beigi F, Moghissi E, Tiktin M, Hirsch IB, Inzucchi SE, et al. (2011) Individualizing glycemic targets in type 2 diabetes mellitus: implications of recent clinical trials. Ann Intern Med 154: 554-559.
2. Vallon V, (2011) The proximal tubule in the pathophysiology of the diabetic kidney. Am J Physiol Regul Integr Comp Physiol 300: R1009-R1022.
3. Giacco F, Brownlee M, (2010) Oxidative stress and diabetic complications. Circ Res 107: 1058-1070.
4. Sivitz WI, Yorek MA, (2010) Mitochondrial dysfunction in diabetes: from molecular mechanisms to functional significance and therapeutic opportunities. Antioxid Redox Signal 12: 537-577.
5. Thuraisingham RC, Nott CA, Dodd SM, Yaqoob MM, (2000) Increased nitrotyrosine staining in kidneys from patients with diabetic nephropathy. Kidney Int 57: 1968-1972.
6. Pergola PE, Raskin P, Toto RD, Meyer CJ, Huff JW, et al. (2011) Bardoxolone methyl and kidney function in CKD with type 2 diabetes. N Engl J Med 365: 327-336.
7. Pergola PE, Krauth M, Huff JW, Ferguson DA, Ruiz S, et al. (2011) Effect of bardoxolone methyl on kidney function in patients with T2D and Stage 3b-4 CKD. Am J Nephrol 33: 469-476.
8. Rossing K, Christensen PK, Hovind P, Tarnow L, Rossing P, et al. (2004) Progression of nephropathy in type 2 diabetic patients. Kidney Int 66: 1596-1605.
9. Hemmingsen B, Lund SS, Gluud C, Vaag A, Almdal T, et al. (2011) Targeting intensive glycaemic control versus targeting conventional glycaemic control for type 2 diabetes mellitus. Cochrane Database Syst Rev 6: CD008143.
10. Liu W, Tang F, Deng Y, Li X, Lan T, et al. (2009) Berberine reduces fibronectin and collagen accumulation in rat glomerular mesangial cells cultured under high glucose condition. Mol Cell Biochem 325: 99-105.
11. Danne T, Spiro MJ, Spiro RG, (1993) Effect of high glucose on type IV collagen production by cultured glomerular epithelial, endothelial, and mesangial cells. Diabetes 42: 170-177.
12. Gilbert RE, Cooper ME, (1999) The tubulointerstitium in progressive diabetic kidney disease: more than an aftermath of glomerular injury? Kidney Int 56: 1627-1637.
13. Jones SC, Saunders HJ, Pollock CA, (1999) High glucose increases growth and collagen synthesis in cultured human tubulointerstitial cells. Diabet Med 16: 932-938.
14. Phillips AO, Steadman R, Morrisey K, Martin J, Eynstone L, et al. (1997) Exposure of human renal proximal tubular cells to glucose leads to accumulation of type IV collagen and fibronectin by decreased degradation. Kidney Int 52: 973-984.
15. Ziyadeh FN, Snipes ER, Watanabe M, Alvarez RJ, Goldfarb S, et al. (1990) High glucose induces cell hypertrophy and stimulates collagen gene transcription in proximal tubule. Am J Physiol 259: F704-F714.
16. Sun L, Xiao L, Nie J, Liu FY, Ling GH, et al. (2010) p66Shc mediates high-glucose and angiotensin II-induced oxidative stress renal tubular injury via mitochondrial-dependent apoptotic pathway. Am J Physiol Renal Physiol 299: F1014-F1025.
17. Munusamy S, MacMillan-Crow LA, (2009) Mitochondrial superoxide plays a crucial role in the development of mitochondrial dysfunction during high glucose exposure in rat renal proximal tubular cells. Free Radic Biol Med 46: 1149-1157.
18. Adams JM 2nd, Pratipanawatr T, Berria R, Wang E, DeFronzo RA, et al. (2004) Ceramide content is increased in skeletal muscle from obese insulin-resistant humans. Diabetes 53: 25-31.
19. Itani SI, Ruderman NB, Schmieder F, Boden G, (2002) Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha. Diabetes 51: 2005-2011.
20. Groop LC, Saloranta C, Shank M, Bonadonna RC, Ferrannini E, et al. (1991) The role of free fatty acid metabolism in the pathogenesis of insulin resistance in obesity and noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 72: 96-107.
21. Golay A, Swislocki AL, Chen YD, Reaven GM, (1987) Relationships between plasma-free fatty acid concentration, endogenous glucose production, and fasting hyperglycemia in normal and non-insulin-dependent diabetic individuals. Metabolism 36: 692-696.
22. Saloranta C, Groop L, (1996) Interactions between glucose and FFA metabolism in man. Diabetes Metab Rev 12: 15-36.
23. Krebs M, Roden M, (2005) Molecular mechanisms of lipid-induced insulin resistance in muscle, liver and vasculature. Diabetes Obes Metab 7: 621-632.
24. Zhang BX, Ma X, Zhang W, Yeh CK, Lin A, et al. (2006) Polyunsaturated fatty acids mobilize intracellular Ca2+ in NT2 human teratocarcinoma cells by causing release of Ca2+ from mitochondria. Am J Physiol Cell Physiol 290: C1321-C1333.
25. Zhang H-M, Dang H, Yeh C-K, Zhang B-X, (2009) Linoleic acid-induced mitochondrial Ca(2+) efflux causes peroxynitrite generation and protein nitrotyrosylation. PLoS ONE 4: e6048.
26. Zhang H, Li ZH, Zhang MQ, Katz MS, Zhang BX, (2008) Heat shock protein 90beta 1 is essential for polyunsaturated fatty acid-induced mitochondrial Ca2+ efflux. J Biol Chem 283: 7580-7589.
27. Sharma K, McCue P, Dunn SR, (2003) Diabetic kidney disease in the db/db mouse. Am J Physiol Renal Physiol 284: F1138-F1144.
28. Dronavalli S, Duka I, Bakris GL, (2008) The pathogenesis of diabetic nephropathy. Nat Clin Pract Endocrinol Metab 4: 444-452.
29. The Diabetes Control and Complications Trial Research Group (1993) The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 329: 977-986.
30. UK Prospective Diabetes Study (UKPDS) Group (1998) Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 352: 837-853.
31. Members of the ADVANCE collaborative group (2008) Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med 358: 2560-2572.
32. Sanchez AP, Sharma K, (2009) Transcription factors in the pathogenesis of diabetic nephropathy. Expert Rev Mol Med 11: e13.
33. Kaneda K, Iwao J, Sakata N, Takebayashi S, (1992) Correlation between mitochondrial enlargement in renal proximal tubules and microalbuminuria in rats with early streptozotocin-induced diabetes. Acta Pathol Jpn 42: 855-860.
34. Nishi S, Ueno M, Hisaki S, Iino N, Iguchi S, et al. (2000) Ultrastructural characteristics of diabetic nephropathy. Med Electron Microsc 33: 65-73.
35. Rosca MG, Mustata TG, Kinter MT, Ozdemir AM, Kern TS, et al. (2005) Glycation of mitochondrial proteins from diabetic rat kidney is associated with excess superoxide formation. Am J Physiol Renal Physiol 289: F420-F430.
36. Ghosh S, Khazaei M, Moien-Afshari F, Ang LS, Granville DJ, et al. (2009) Moderate exercise attenuates caspase-3 activity, oxidative stress, and inhibits progression of diabetic renal disease in db/db mice. Am J Physiol Renal Physiol 296: F700-F708.
37. Takahashi K, Kamijo Y, Hora K, Hashimoto K, Higuchi M, et al. (2011) Pretreatment by low-dose fibrates protects against acute free fatty acid-induced renal tubule toxicity by counteracting PPARa deterioration. Toxicol Appl Pharmacol 252: 237-249.
38. Zhang H, Zhang H-M, Wu LP, Tan DX, Kamat A, et al. (2011) Impaired mitochondrial complex III and melatonin responsive reactive oxygen species generation in kidney mitochondria of db/db mice. J Pineal Res 51: 338-344.
39. Zhang H-M, Zhang Y, Zhang B-X, (2011) The role of mitochondrial complex III in melatonin-induced ROS production in cultured mesangial cells. J Pineal Res 50: 78-82.
40. Tuo Y, Wang D, Li S, Chen C, (2011) Long-term exposure of INS-1 rat insulinoma cells to linoleic acid and glucose in vitro affects cell viability and function through mitochondrial-mediated pathways. Endocrine 39: 128-138.
41. Tokui K, Adachi H, Waza M, Katsuno M, Minamiyama M, et al. (2009) 17-DMAG ameliorates polyglutamine-mediated motor neuron degeneration through well-preserved proteasome function in an SBMA model mouse. Hum Mol Genet 18: 898-910.
42. Kang BH, Plescia J, Dohi T, Rosa J, Doxsey SJ, et al. (2007) Regulation of tumor cell mitochondrial homeostasis by an organelle-specific hsp90 chaperone network. Cell 131: 257-270.
43. Kang BH, Plescia J, Song HY, Meli M, Colombo G, et al. (2009) Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90. J Clin Invest 119: 454-464.
44. Sumanasekera WK, Tien ES, Davis JW 2nd, Turpey R, Perdew GH, et al. (2003) Heat shock protein-90 (Hsp90) acts as a repressor of peroxisome proliferator-activated receptor-alpha (PPARalpha) and PPARbeta activity. Biochemistry 42: 10726-10735.
45. Barutta F, Pinach S, Giunti S, Vittone F, Forbes JM, et al. (2008) Heat shock protein expression in diabetic nephropathy. Am J Physiol Renal Physiol 295: F1817-F1824.
46. Hojlund K, Wrzesinski K, Larsen PM, Fey SJ, Roepstorff P, et al. (2003) Proteome Analysis Reveals Phosphorylation of ATP Synthase beta-Subunit in Human Skeletal Muscle and Proteins with Potential Roles in Type 2 Diabetes. J Biol Chem 278: 10436-10442.
47. Hansford R, Zorov D, (1998) Role of mitochondrial calcium transport in the control of substrate oxidation. Mol Cell Biochem 184: 359-369.
48. Visch HJ, Koopman WJ, Zeegers D, van Emst-de Vries SE, van Kuppeveld FJ, et al. (2006) Ca2+-mobilizing agonists increase mitochondrial ATP production to accelerate cytosolic Ca2+ removal: aberrations in human complex I deficiency. Am J Physiol Cell Physiol 291: C308-C316.
49. Brookes PS, Yoon Y, Robotham JL, Anders MW, Sheu SS, (2004) Calcium, ATP, and ROS: a mitochondrial love-hate triangle. Am J Physiol Cell Physiol 287: C817-C833.
50. Kamijo A, Kimura K, Sugaya T, Yamanouchi M, Hase H, et al. (2002) Urinary free fatty acids bound to albumin aggravate tubulointerstitial damage. Kidney Int 62: 1628-1637.
51. Yi L, He J, Liang Y, Yuan D, Gao H, et al. (2007) Simultaneously quantitative measurement of comprehensive profiles of esterified and non-esterified fatty acid in plasma of type 2 diabetic patients. Chem Phys Lipids 150: 204-216.
52. Shishehbor MH, Aviles RJ, Brennan ML, Fu X, Goormastic M, et al. (2003) Association of nitrotyrosine levels with cardiovascular disease and modulation by statin therapy. JAMA 289: 1675-1680.
53. Ceriello A, Mercuri F, Quagliaro L, Assaloni R, Motz E, et al. (2001) Detection of nitrotyrosine in the diabetic plasma: evidence of oxidative stress. Diabetologia 44: 834-838.
54. Danda RS, Habiba NM, Rincon-Choles H, Bhandari BK, Barnes JL, et al. (2005) Kidney involvement in a nongenetic rat model of type 2 diabetes. Kidney Int 68: 2562-2571.
55. Lauronen J, Häyry P, Paavonen T, (2006) An image analysis-based method for quantification of chronic allograft damage index parameters. APMIS 114: 440-448.
56. Serón D, Moreso F, (2007) Protocol biopsies in renal transplantation: prognostic value of structural monitoring. Kidney Int 72: 690-697.
57. van der Loos CM, Göbel H, (2000) The animal research kit (ARK) can be used in a multistep double staining method for human tissue specimens. J Histochem Cytochem 48: 1431-1438.