Ca2+-mobilizing agonists increase mitochondrial ATP production to accelerate cytosolic Ca2+ removal: Aberrations in human complex I deficiency

American Journal of Physiology - Cell Physiology

Volumn 291, Issue 2, 2006, Pages

  Visch, Henk Jan ^a   Koopman, Werner J H ^a,b   Zeegers, Dimphy ^a   Van Emst de Vries, Sjenet E ^a   Van Kuppeveld, Frank J M ^a   Van Den Heuvel, Lambertus W P J ^a   Smeitink, Jan A M ^a   Willems, Peter H G M ^a,b  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Calcium ion extrusion; CGP 37157; Human skin fibroblast; OXPHOS disease; Rhod 2

Indexed keywords

7 CHLORO 5 (2 CHLOROPHENYL) 1,5 DIHYDRO 4,1 BENZOTHIAZEPIN 2(3H) ONE; ADENOSINE TRIPHOSPHATE; AEQUORIN; BRADYKININ; CALCIUM CHANNEL STIMULATING AGENT; CALCIUM ION; FLUORESCENT DYE; FURA 2; LUCIFERASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; RHOD 2; RHODAMINE; UNCLASSIFIED DRUG; CALCIUM; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE);

ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CALCIUM TRANSPORT; COMPLEX I DEFICIENCY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSOL; DRUG INHIBITION; DRUG MECHANISM; FIBROBLAST; HUMAN; HUMAN CELL; MICROSCOPY; MITOCHONDRION; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; BIOSYNTHESIS; CALCIUM SIGNALING; CELL CULTURE; DOSE RESPONSE; DRUG EFFECT; METABOLISM;

ADENOSINE TRIPHOSPHATE; BRADYKININ; CALCIUM; CALCIUM SIGNALING; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRON TRANSPORT COMPLEX I; FIBROBLASTS; HUMANS; MITOCHONDRIA;

EID: 33746622500     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00561.2005     Document Type: Article

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