Discovery and development of potent LFA-1/ICAM-1 antagonist SAR 1118 as an ophthalmic solution for treating dry eye

ACS Medicinal Chemistry Letters

Volumn 3, Issue 3, 2012, Pages 203-206

  Zhong, Min ^a,c   Gadek, Thomas R ^b   Bui, Minna ^a   Shen, Wang ^a   Burnier, John ^b   Barr, Kenneth J ^a   Hanan, Emily J ^a   Oslob, Johan D ^a   Yu, Chul H ^a   Zhu, Jiang ^a   Arkin, Michelle R ^a   Evanchik, Marc J ^a   Flanagan, W Mike ^a   Hoch, Ute ^a   Hyde, Jennifer ^a   Prabhu, Saileta ^a   Silverman, Jeffrey A ^a   Wright, Jasmin ^a  

^a Sunesis Pharmaceuticals Inc   (United States)

^b SARcode Bioscience Inc   (United States)

^c Presidio Pharmaceuticals Inc   (United States)

Author keywords

dry eye; LFA 1 ICAM 1 antagonist; ophthalmic solution; SAR 1118; tetrahydroisoquinoline derivative

Indexed keywords

EYE DROPS; INTERCELLULAR ADHESION MOLECULE 1; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; SAR 1118; UNCLASSIFIED DRUG;

ACINAR CELL; ANTIGEN EXPRESSION; ARTICLE; CONJUNCTIVA; DRUG DEVELOPMENT; DRY EYE; EPITHELIUM CELL; HUMAN; HYPOTHESIS; IC 50; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; TOPICAL TREATMENT;

ANIMALIA;

EID: 84863275884     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml2002482     Document Type: Article

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