Liver Patt1 deficiency protects male mice from age-associated but not high-fat diet-induced hepatic steatosis

Journal of Lipid Research

Volumn 53, Issue 3, 2012, Pages 358-367

  Liu, Yang ^a   Zhou, Daizhan ^a   Zhang, Fang ^a   Tu, Yanyang ^a   Xia, Yulei ^a   Wang, Hui ^a   Zhou, Ben ^a   Zhang, Yi ^a   Wu, Jingxia ^a   Gao, Xiang ^b   He, Zhishui ^a   Zhai, Qiwei ^a  

^a UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^b NANJING UNIVERSITY   (China)

Author keywords

Acetyltransferase; Lipid metabolism; Liver specific

Indexed keywords

CHOLESTEROL; FAT DROPLET; FATTY ACID; HISTONE ACETYLTRANSFERASE GCN5; PALMITIC ACID; PROTEIN PATT1; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOLESTEROL LIVER LEVEL; CONTROLLED STUDY; FATTY ACID BLOOD LEVEL; FATTY ACID OXIDATION; FATTY LIVER; KNOCKOUT MOUSE; LIPID DIET; LIPID METABOLISM; LIPID STORAGE; LIPOGENESIS; LIVER CELL CULTURE; LIVER FUNCTION; LIVER WEIGHT; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY;

ACETYLTRANSFERASES; ANIMALS; BODY WEIGHT; CELLS, CULTURED; CHOLESTEROL; DIET, HIGH-FAT; EATING; FATTY ACIDS, NONESTERIFIED; FATTY LIVER; IMMUNOBLOTTING; IMMUNOPRECIPITATION; LIPID METABOLISM; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PALMITIC ACID; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRIGLYCERIDES;

EID: 84863268084     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M019257     Document Type: Article

References (53)

1. Ekstedt, M., L. E. Franzen, U. L. Mathiesen, L. Thorelius, M. Holmqvist, G. Bodemar, and S. Kechagias. 2006. Long-term follow-up of patients with NAFLD and elevated liver enzymes. Hepatology. 44: 865-873. (Pubitemid 46489550)
2. Farrell, G. C., and C. Z. Larter. 2006. Nonalcoholic fatty liver disease: from steatosis to cirrhosis. Hepatology. 43: S99-S112.
3. de Alwis, N. M., and C. P. Day. 2008. Non-alcoholic fatty liver disease: the mist gradually clears. J. Hepatol. 48(Suppl. 1): S104-S112.
4. Bedogni, G., L. Miglioli, F. Masutti, C. Tiribelli, G. Marchesini, and S. Bellentani. 2005. Prevalence of and risk factors for nonalcoholic fatty liver disease: the Dionysos nutrition and liver study. Hepatology. 42: 44-52. (Pubitemid 40911310)
5. Perez-Daga, J. A., J. Santoyo, M. A. Suarez, J. A. Fernandez-Aguilar, C. Ramirez, A. Rodriguez-Canete, J. M. Aranda, B. Sanchez-Perez, C. Montiel, D. Palomo, et al. 2006. Influence of degree of hepatic steatosis on graft function and postoperative complications of liver transplantation. Transplant. Proc. 38: 2468-2470. (Pubitemid 44767862)
6. Angulo, P. 2002. Nonalcoholic fatty liver disease. N. Engl. J. Med. 346: 1221-1231.
7. de Jesus, B. B., K. Schneeberger, E. Vera, A. Tejera, C. B. Harley, and M. A. Blasco. 2011. The telomerase activator TA-65 elongates short telomeres and increases health span of adult/old mice without increasing cancer incidence. Aging Cell. 10: 604-621.
8. Postic, C., and J. Girard. 2008. Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice. J. Clin. Invest. 118: 829-838. (Pubitemid 351364588)
9. Adams, L. A., and P. Angulo. 2006. Treatment of non-alcoholic fatty liver disease. Postgrad. Med. J. 82: 315-322. (Pubitemid 43780662)
10. Ahmed, M. H., and C. D. Byrne. 2009. Current treatment of non-alcoholic fatty liver disease. Diabetes Obes. Metab. 11: 188-195.
11. Arendt, B. M., and J. P. Allard. 2011. Effect of atorvastatin, vitamin E and C on nonalcoholic fatty liver disease: is the combination required? Am. J. Gastroenterol. 106: 78-80.
12. Ahmed, M. H., E. O. Abu, and C. D. Byrne. 2010. Non-alcoholic fatty liver disease (NAFLD): new challenge for general practitioners and important burden for health authorities? Prim. Care Diabetes. 4: 129-137.
13. Musso, G., R. Gambino, and M. Cassader. 2010. Emerging molecular targets for the treatment of nonalcoholic fatty liver disease. Annu. Rev. Med. 61: 375-392.
14. van Beekum, O., V. Fleskens, and E. Kalkhoven. 2009. Post-translational modifications of PPAR-gamma: fine-tuning the metabolic master regulator. Obesity (Silver Spring). 17: 213-219.
15. Guan, K. L., and Y. Xiong. 2011. Regulation of intermediary metabolism by protein acetylation. Trends Biochem. Sci. 36: 108-116.
16. Zhao, S., W. Xu, W. Jiang, W. Yu, Y. Lin, T. Zhang, J. Yao, L. Zhou, Y. Zeng, H. Li, et al. 2010. Regulation of cellular metabolism by protein lysine acetylation. Science. 327: 1000-1004.
17. Purushotham, A., T. T. Schug, Q. Xu, S. Surapureddi, X. Guo, and X. Li. 2009. Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation. Cell Metab. 9: 327-338.
18. Hirschey, M. D., T. Shimazu, E. Goetzman, E. Jing, B. Schwer, D. B. Lombard, C. A. Grueter, C. Harris, S. Biddinger, O. R. Ilkayeva, et al. 2010. SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature. 464: 121-125.
19. Kim, H. S., C. Xiao, R. H. Wang, T. Lahusen, X. Xu, A. Vassilopoulos, G. Vazquez-Ortiz, W. I. Jeong, O. Park, S. H. Ki, et al. 2010. Hepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis. Cell Metab. 12: 224-236.
20. Bricambert, J., J. Miranda, F. Benhamed, J. Girard, C. Postic, and R. Dentin. 2010. Salt-inducible kinase 2 links transcriptional coactivator p300 phosphorylation to the prevention of ChREBP-dependent hepatic steatosis in mice. J. Clin. Invest. 120: 4316-4331.
21. Giandomenico, V., M. Simonsson, E. Gronroos, and J. Ericsson. 2003. Coactivator-dependent acetylation stabilizes members of the SREBP family of transcription factors. Mol. Cell. Biol. 23: 2587-2599. (Pubitemid 36351037)
22. You, M., X. Liang, J. M. Ajmo, and G. C. Ness. 2008. Involvement of mammalian sirtuin 1 in the action of ethanol in the liver. Am. J. Physiol. Gastrointest. Liver Physiol. 294: G892-G898. (Pubitemid 351520077)
23. Gelman, L., G. Zhou, L. Fajas, E. Raspe, J. C. Fruchart, and J. Auwerx. 1999. p300 interacts with the N- and C-terminal part of PPARgamma2 in a ligand-independent and -dependent manner, respectively. J. Biol. Chem. 274: 7681-7688.
24. Kelly, T. J., C. Lerin, W. Haas, S. P. Gygi, and P. Puigserver. 2009. GCN5-mediated transcriptional control of the metabolic coactivator PGC-1beta through lysine acetylation. J. Biol. Chem. 284: 19945-19952.
25. Wiper-Bergeron, N., H. A. Salem, J. J. Tomlinson, D. Wu, and R. J. Hache. 2007. Glucocorticoid-stimulated preadipocyte differentiation is mediated through acetylation of C/EBPbeta by GCN5. Proc. Natl. Acad. Sci. USA. 104: 2703-2708. (Pubitemid 46327943)
26. Ge, X., Q. Jin, F. Zhang, T. Yan, and Q. Zhai. 2009. PCAF acetylates {beta}-catenin and improves its stability. Mol. Biol. Cell. 20: 419-427.
27. Liu, H., M. M. Fergusson, J. J. Wu, I. I. Rovira, J. Liu, O. Gavrilova, T. Lu, J. Bao, D. Han, M. N. Sack, et al. 2011. Wnt signaling regulates hepatic metabolism. Sci. Signal. 4: ra6.
28. Liu, Z., Y. Liu, H. Wang, X. Ge, Q. Jin, G. Ding, Y. Hu, B. Zhou, Z. Chen, B. Zhang, et al. 2009. Patt1, a novel protein acetyltransferase that is highly expressed in liver and downregulated in hepatocellular carcinoma, enhances apoptosis of hepatoma cells. Int. J. Biochem. Cell Biol. 41: 2528-2537.
29. Sun, C., F. Zhang, X. Ge, T. Yan, X. Chen, X. Shi, and Q. Zhai. 2007. SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B. Cell Metab. 6: 307-319. (Pubitemid 47468091)
30. Blanchard, C. Z., Y. M. Lee, P. A. Frantom, and G. L. Waldrop. 1999. Mutations at four active site residues of biotin carboxylase abolish substrate-induced synergism by biotin. Biochemistry. 38: 3393-3400.
31. Ramsay, R. R., J. P. Derrick, A. S. Friend, and P. K. Tubbs. 1987. Purification and properties of the soluble carnitine palmitoyltransferase from bovine liver mitochondria. Biochem. J. 244: 271-278. (Pubitemid 17087089)
32. Kasuya, F., K. Igarashi, and M. Fukui. 1996. Participation of a medium chain acyl-CoA synthetase in glycine conjugation of the benzoic acid derivatives with the electron-donating groups. Biochem. Pharmacol. 51: 805-809. (Pubitemid 26096293)
33. McEneny, J., C. McMaster, E. R. Trimble, and I. S. Young. 2002. Rapid isolation of VLDL subfractions: assessment of composition and susceptibility to copper-mediated oxidation. J. Lipid Res. 43: 824-831. (Pubitemid 34477910)
34. Chung, C., J. A. Doll, A. K. Gattu, C. Shugrue, M. Cornwell, P. Fitchev, and S. E. Crawford. 2008. Anti-angiogenic pigment epithelium-derived factor regulates hepatocyte triglyceride content through adipose triglyceride lipase (ATGL). J. Hepatol. 48: 471-478.
35. Wang, Q., L. Jiang, J. Wang, S. Li, Y. Yu, J. You, R. Zeng, X. Gao, L. Rui, W. Li, et al. 2009. Abrogation of hepatic ATP-citrate lyase protects against fatty liver and ameliorates hyperglycemia in leptin receptor-deficient mice. Hepatology. 49: 1166-1175.
36. Mathijs, K., A. S. Kienhuis, K. J. Brauers, D. G. Jennen, A. Lahoz, J. C. Kleinjans, and J. H. van Delft. 2009. Assessing the metabolic competence of sandwich-cultured mouse primary hepatocytes. Drug Metab. Dispos. 37: 1305-1311.
37. Donato, M. T., A. Lahoz, N. Jimenez, G. Perez, A. Serralta, J. Mir, J. V. Castell, and M. J. Gomez-Lechon. 2006. Potential impact of steatosis on cytochrome P450 enzymes of human hepatocytes isolated from fatty liver grafts. Drug Metab. Dispos. 34: 1556-1562. (Pubitemid 44285398)
38. Park, S. G., Y. S. Kang, J. Y. Kim, C. S. Lee, Y. G. Ko, W. J. Lee, K. U. Lee, Y. I. Yeom, and S. Kim. 2006. Hormonal activity of AIMP1/p43 for glucose homeostasis. Proc. Natl. Acad. Sci. USA. 103: 14913-14918. (Pubitemid 44527828)
39. Joost, H. G., and H. J. Steinfelder. 1982. Modulation of insulin sensitivity by adenosine. Effects on glucose transport, lipid synthesis, and insulin receptors of the adipocyte. Mol. Pharmacol. 22: 614-618. (Pubitemid 13201819)
40. Abu-Elheiga, L., W. Oh, P. Kordari, and S. J. Wakil. 2003. Acetyl-CoA carboxylase 2 mutant mice are protected against obesity and diabetes induced by high-fat/high-carbohydrate diets. Proc. Natl. Acad. Sci. USA. 100: 10207-10212. (Pubitemid 37071857)
41. Sleeman, M. W., K. Garcia, R. Liu, J. D. Murray, L. Malinova, M. Moncrieffe, G. D. Yancopoulos, and S. J. Wiegand. 2003. Ciliary neurotrophic factor improves diabetic parameters and hepatic steatosis and increases basal metabolic rate in db/db mice. Proc. Natl. Acad. Sci. USA. 100: 14297-14302. (Pubitemid 37499231)
42. Musso, G., R. Gambino, and M. Cassader. 2009. Recent insights into hepatic lipid metabolism in non-alcoholic fatty liver disease (NAFLD). Prog. Lipid Res. 48: 1-26.
43. Browning, J. D., and J. D. Horton. 2004. Molecular mediators of hepatic steatosis and liver injury. J. Clin. Invest. 114: 147-152. (Pubitemid 39071617)
44. Ha, J., S. Daniel, S. S. Broyles, and K. H. Kim. 1994. Critical phosphorylation sites for acetyl-CoA carboxylase activity. J. Biol. Chem. 269: 22162-22168. (Pubitemid 24282143)
45. Hooper, A. J., L. A. Adams, and J. R. Burnett. 2011. Genetic determinants of hepatic steatosis in man. J. Lipid Res. 52: 593-617.
46. Orellana-Gavaldà, J. M., L. Herrero, M. I. Malandrino, A. Paneda, M. Sol Rodriguez-Pena, H. Petry, G. Asins, S. Van Deventer, F. G. Hegardt, and D. Serra. 2011. Molecular therapy for obesity and diabetes based on a long-term increase in hepatic fatty-acid oxidation. Hepatology. 53: 821-832.
47. Kuk, J. L., T. J. Saunders, L. E. Davidson, and R. Ross. 2009. Age-related changes in total and regional fat distribution. Ageing Res. Rev. 8: 339-348.
48. Tollet-Egnell, P., P. Parini, N. Stahlberg, I. Lonnstedt, N. H. Lee, M. Rudling, A. Flores-Morales, and G. Norstedt. 2004. Growth hormone-mediated alteration of fuel metabolism in the aged rat as determined from transcript profiles. Physiol. Genomics. 16: 261-267. (Pubitemid 38420044)
49. Murthy, V. K., O. A. Oredipe, M. R. Stiles, and J. C. Shipp. 1986. Increased fatty acid uptake, a factor in increased hepatic triacylglycerol synthesis in aging rats. Mech. Ageing Dev. 37: 49-54. (Pubitemid 17209971)
50. Mori, S., N. Morisaki, Y. Saito, and S. Yoshida. 1988. Age-related changes of long-chain fatty acid metabolism in rat liver. Mech. Ageing Dev. 44: 175-183.
51. Church, C., S. Lee, E. A. Bagg, J. S. McTaggart, R. Deacon, T. Gerken, A. Lee, L. Moir, J. Mecinovic, M. M. Quwailid, et al. 2009. A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene. PLoS Genet. 5: e1000599.
52. Wang, S., N. Yehya, E. E. Schadt, H. Wang, T. A. Drake, and A. J. Lusis. 2006. Genetic and genomic analysis of a fat mass trait with complex inheritance reveals marked sex specificity. PLoS Genet. 2: e15.
53. Sabio, G., J. Cavanagh-Kyros, H. J. Ko, D. Y. Jung, S. Gray, J. Y. Jun, T. Barrett, A. Mora, J. K. Kim, and R. J. Davis. 2009. Prevention of steatosis by hepatic JNK1. Cell Metab. 10: 491-498.