Absence of association between N-Acetyltransferase 2 acetylator status and colorectal cancer susceptibility: Based on evidence from 40 studies

PLoS ONE

Volumn 7, Issue 3, 2012, Pages

  Zhang, Lou qian ^a,b   Zhou, Jian nong ^a   Wang, Jun ^b   Liang, Guo dong ^b   Li, Jing ying ^c   Zhu, Yi dan ^b   Su, Yun tao ^c  

^a JIANGSU CANCER HOSPITAL   (China)

^b Jiangsu Official Hospital   (China)

^c THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ARYLAMINE ACETYLTRANSFERASE; NAT2 PROTEIN, HUMAN;

ACETYLATION; ARTICLE; CANCER LOCALIZATION; CANCER RISK; CANCER SUSCEPTIBILITY; COLORECTAL CANCER; DISEASE ASSOCIATION; FEMALE; GENETIC ASSOCIATION; GENETIC HETEROGENEITY; GENOTYPE; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; TUMOR LOCALIZATION; TUMOR VASCULARIZATION; COLORECTAL TUMOR; DISEASE PREDISPOSITION; ENZYMOLOGY; GENETICS; META ANALYSIS; METABOLISM; PUBLISHING; RISK;

ACETYLATION; ARYLAMINE N-ACETYLTRANSFERASE; COLORECTAL NEOPLASMS; DISEASE SUSCEPTIBILITY; FEMALE; HUMANS; MALE; PHENOTYPE; PUBLICATION BIAS; RISK;

EID: 84863264713     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0032425     Document Type: Article

References (60)

1. Edwards BK, Brown ML, Wingo PA, Howe HL, Ward E, et al. (2005) Annual report to the nation on the status of cancer, 1975-2002, featuring population-based trends in cancer treatment. J Natl Cancer Inst 97: 1407-1427.
2. Desai TK, Barkel D, (2008) Syndromic colon cancer: lynch syndrome and familial adenomatous polyposis. Gastroenterol Clin North Am 37: 47-72, vi.
3. de Jong MM, Nolte IM, te Meerman GJ, van der Graaf WT, de Vries EG, et al. (2002) Low-penetrance genes and their involvement in colorectal cancer susceptibility. Cancer Epidemiol Biomarkers Prev 11: 1332-1352.
4. Sasco AJ, Secretan MB, Straif K, (2004) Tobacco smoking and cancer: a brief review of recent epidemiological evidence. Lung Cancer 45 (Suppl 2): S3-9.
5. Norat T, Lukanova A, Ferrari P, Riboli E, (2002) Meat consumption and colorectal cancer risk: dose-response meta-analysis of epidemiological studies. Int J Cancer 98: 241-256.
6. Potter JD, Bigler J, Fosdick L, Bostick RM, Kampman E, et al. (1999) Colorectal adenomatous and hyperplastic polyps: smoking and N-acetyltransferase 2 polymorphisms. Cancer Epidemiol Biomarkers Prev 8: 69-75.
7. Smith CA, Smith G, Wolf CR, (1994) Genetic polymorphisms in xenobiotic metabolism. Eur J Cancer 30A: 1921-1935.
8. Hein DW, (2002) Molecular genetics and function of NAT1 and NAT2: role in aromatic amine metabolism and carcinogenesis. Mutat Res 506-507: 65-77.
9. Shibuta K, Nakashima T, Abe M, Mashimo M, Mori M, et al. (1994) Molecular genotyping for n-acetylation polymorphism in Japanese patients with colorectal cancer. Cancer 74: 3108-3112.
10. Oda Y, Tanaka M, Nakanishi I, (1994) Relation between the occurrence of K-ras gene point mutations and genotypes of polymorphic N-acetyltransferase in human colorectal carcinomas. Carcinogenesis 15: 1365-1369.
11. Lang NP, Butler MA, Massengill J, Lawson M, Stotts RC, et al. (1994) Rapid metabolic phenotypes for acetyltransferase and cytochrome P4501A2 and putative exposure to food-borne heterocyclic amines increase the risk for colorectal cancer or polyps. Cancer Epidemiol Biomarkers Prev 3: 675-682.
12. Rodriguez JW, Kirlin WG, Ferguson RJ, Doll MA, Gray K, et al. (1993) Human acetylator genotype: Relationship to colorectal cancer incidence and arylamine N-acetyltransferase expression in colon cytosol. Archives of Toxicology 67: 445-452.
13. Ladero JM, Gonzalez JF, Benitez J, Vargas E, Fernandez MJ, et al. (1991) Acetylator polymorphism in human colorectal carcinoma. Cancer Res 51: 2098-2100.
14. Wang H, Yamamoto JF, Caberto C, Saltzman B, Decker R, et al. (2011) Genetic variation in the bioactivation pathway for polycyclic hydrocarbons and heterocyclic amines in relation to risk of colorectal neoplasia. Carcinogenesis 32: 203-209.
15. da Silva TD, Felipe AV, de Lima JM, Oshima CT, Forones NM, (2011) N-Acetyltransferase 2 genetic polymorphisms and risk of colorectal cancer. World J Gastroenterol 17: 760-765.
16. Cleary SP, Cotterchio M, Shi E, Gallinger S, Harper P, (2010) Cigarette smoking, genetic variants in carcinogen-metabolizing enzymes, and colorectal cancer risk. Am J Epidemiol 172: 1000-1014.
17. Zupa A, Sgambato A, Bianchino G, Improta G, Grieco V, et al. (2009) GSTM1 and NAT2 polymorphisms and colon, lung and bladder cancer risk: a case-control study. Anticancer Res 29: 1709-1714.
18. Yeh CC, Sung FC, Tang R, Chang-Chieh CR, Hsieh LL, (2009) Polymorphisms of cytochrome P450 1A2 and n-acetyltransferase genes, meat consumption, and risk of colorectal cancer. Diseases of the Colon and Rectum 52: 104-111.
19. Nothlings U, Yamamoto JF, Wilkens LR, Murphy SP, Park SY, et al. (2009) Meat and heterocyclic amine intake, smoking, NAT1 and NAT2 polymorphisms, and colorectal cancer risk in the multiethnic cohort study. Cancer Epidemiology Biomarkers and Prevention 18: 2098-2106.
20. Kobayashi M, Otani T, Iwasaki M, Natsukawa S, Shaura K, et al. (2009) Association between dietary heterocyclic amine levels, genetic polymorphisms of NAT2, CYP1A1, and CYP1A2 and risk of colorectal cancer: A hospital-based case-control study in Japan. Scandinavian Journal of Gastroenterology 44: 952-959.
21. Sorensen M, Autrup H, Olsen A, Tjonneland A, Overvad K, et al. (2008) Prospective study of NAT1 and NAT2 polymorphisms, tobacco smoking and meat consumption and risk of colorectal cancer. Cancer Letters 266: 186-193.
22. Butler LM, Millikan RC, Sinha R, Keku TO, Winkel S, et al. (2008) Modification by N-acetyltransferase 1 genotype on the association between dietary heterocyclic amines and colon cancer in a multiethnic study. Mutation Research- Fundamental and Molecular Mechanisms of Mutagenesis 638: 162-174.
23. Yoshida K, Osawa K, Kasahara M, Miyaishi A, Nakanishi K, et al. (2007) Association of CYP1A1, CYP1A2, GSTM1 and NAT2 gene polymorphisms with colorectal cancer and smoking. Asian Pac J Cancer Prev 8: 438-444.
24. Pistorius S, Goergens H, Engel C, Plaschke J, Krueger S, et al. (2007) N-Acetyltransferase (NAT) 2 acetylator status and age of tumour onset in patients with sporadic and familial, microsatellite stable (MSS) colorectal cancer. Int J Colorectal Dis 22: 137-143.
25. Mahid SS, Colliver DW, Crawford NPS, Martini BD, Doll MA, et al. (2007) Characterization of N-acetyltransferase 1 and 2 polymorphisms and haplotype analysis for inflammatory bowel disease and sporadic colorectal carcinoma. BMC Medical Genetics 8.
26. Huang CC, Chien WP, Wong RH, Cheng YW, Chen MC, et al. (2007) NAT2 fast acetylator genotype is associated with an increased risk of colorectal cancer in Taiwan. Dis Colon Rectum 50: 981-989.
27. Lilla C, Verla-Tebit E, Risch A, Jager B, Hoffmeister M, et al. (2006) Effect of NAT1 and NAT2 genetic polymorphisms on colorectal cancer risk associated with exposure to tobacco smoke and meat consumption. Cancer Epidemiology Biomarkers and Prevention 15: 99-107.
28. Borlak J, Reamon-Buettner SM, (2006) N-acetyltransferase 2 (NAT2) gene polymorphisms in colon and lung cancer patients. BMC Med Genet 7: 58.
29. Landi S, Gemignani F, Moreno V, Gioia-Patricola L, Chabrier A, et al. (2005) A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of colorectal cancer. Pharmacogenetics and Genomics 15: 535-546.
30. He LJ, Yu YM, Qiao F, Liu JS, Sun XF, et al. (2005) Genetic polymorphisms of N-acetyltransferase 2 and colorectal cancer risk. World J Gastroenterol 11: 4268-4271.
31. Chen K, Jin MJ, Fan CH, Song L, Jiang QT, et al. (2005) A case-control study on the association between genetic polymorphisms of metabolic enzymes and the risk of colorectal cancer. Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi 26: 659-664.
32. Slattery ML, Samowtiz W, Ma K, Murtaugh M, Sweeney C, et al. (2004) CYP1A1, cigarette smoking, and colon and rectal cancer. Am J Epidemiol 160: 842-852.
33. Kiss I, Nemeth A, Bogner B, Pajkos G, Orsos Z, et al. (2004) Polymorphisms of glutathione-S-transferase and arylamine N-acetyltransferase enzymes and susceptibility to colorectal cancer. Anticancer Research 24: 3965-3970.
34. Van Der Hel OL, Bueno De Mesquita HB, Sandkuijl L, Van Noord PAH, Pearson PL, et al. (2003) Rapid N-acetyltransferase 2 imputed phenotype and smoking may increase risk of colorectal cancer in women (Netherlands). Cancer Causes and Control 14: 293-298.
35. Barrett JH, Smith G, Waxman R, Gooderham N, Lightfoot T, et al. (2003) Investigation of interaction between N-acetyltransferase 2 and heterocyclic amines as potential risk factors for colorectal cancer. Carcinogenesis 24: 275-282.
36. Tiemersma EW, Kampman E, Bueno de Mesquita HB, Bunschoten A, van Schothorst EM, et al. (2002) Meat consumption, cigarette smoking, and genetic susceptibility in the etiology of colorectal cancer: results from a Dutch prospective study. Cancer Causes Control 13: 383-393.
37. Le Marchand L, Hankin JH, Wilkens LR, Pierce LM, Franke A, et al. (2001) Combined effects of well-done red meat, smoking, and rapid N-acetyltransferase 2 and CYP1A2 phenotypes in increasing colorectal cancer risk. Cancer Epidemiol Biomarkers Prev 10: 1259-1266.
38. Butler WJ, Ryan P, Roberts-Thomson IC, (2001) Metabolic genotypes and risk for colorectal cancer. Journal of Gastroenterology and Hepatology 16: 631-635.
39. Katoh T, Boissy R, Nagata N, Kitagawa K, Kuroda Y, et al. (2000) Inherited polymorphism in the N-acetyltransferase 1 (NAT1) and 2 (NAT2) genes and susceptibility to gastric and colorectal adenocarcinoma. Int J Cancer 85: 46-49.
40. Slattery ML, Potter JD, Samowitz W, Bigler J, Caan B, et al. (1998) NAT2, GSTM-1, cigarette smoking, and risk of colon cancer. Cancer Epidemiol Biomarkers Prev 7: 1079-1084.
41. Lee EJ, Zhao B, Seow-Choen F, (1998) Relationship between polymorphism of N-acetyltransferase gene and susceptibility to colorectal carcinoma in a Chinese population. Pharmacogenetics 8: 513-517.
42. Chen J, Stampfer MJ, Hough HL, Garcia-Closas M, Willett WC, et al. (1998) A prospective study of N-acetyltransferase genotype, red meat intake, and risk of colorectal cancer. Cancer Research 58: 3307-3311.
43. Welfare MR, Cooper J, Bassendine MF, Daly AK, (1997) Relationship between acetylator status, smoking, diet and colorectal cancer risk in the north-east of England. Carcinogenesis 18: 1351-1354.
44. Hubbard AL, Harrison DJ, Moyes C, Wyllie AH, Cunningham C, et al. (1997) N-acetyltransferase 2 genotype in colorectal cancer and selective gene retention in cancers with chromosome 8p deletions. Gut 41: 229-234.
45. Gil JP, Lechner MC, (1998) Increased frequency of wild-type arylamine-N-acetyltransferase allele NAT2*4 homozygotes in Portuguese patients with colorectal cancer. Carcinogenesis 19: 37-41.
46. Bell DA, Stephens EA, Castranio T, Umbach DM, Watson M, et al. (1995) Polyadenylation polymorphism in the acetyltransferase 1 gene (NAT1) increases risk of colorectal cancer. Cancer Research 55: 3537-3542.
47. Ilett KF, David BM, Detchon P, Castleden WM, Kwa R, (1987) Acetylation phenotype in colorectal carcinoma. Cancer Res 47: 1466-1469.
48. Lang NP, Chu DZ, Hunter CF, Kendall DC, Flammang TJ, et al. (1986) Role of aromatic amine acetyltransferase in human colorectal cancer. Arch Surg 121: 1259-1261.
49. Ye Z, Parry JM, (2002) Meta-analysis of 20 case-control studies on the N-acetyltransferase 2 acetylation status and colorectal cancer risk. Medical Science Monitor 8: CR558-CR565.
50. Sanderson S, Salanti G, Higgins J, (2007) Joint effects of the N-acetyltransferase 1 and 2 (NAT1 and NAT2) genes and smoking on bladder carcinogenesis: a literature-based systematic HuGE review and evidence synthesis. Am J Epidemiol 166: 741-751.
51. Cui D, Wang Z, Zhao E, Ma J, Lu W, (2011) NAT2 polymorphism and lung cancer risk: A meta-analysis. Lung Cancer.
52. Zhong X, Hui C, Xiao-Ling W, Yan L, Na L, (2010) NAT2 polymorphism and gastric cancer susceptibility: a meta-analysis. Arch Med Res 41: 275-280.
53. Ambrosone CB, Kropp S, Yang J, Yao S, Shields PG, et al. (2008) Cigarette smoking, N-acetyltransferase 2 genotypes, and breast cancer risk: pooled analysis and meta-analysis. Cancer Epidemiol Biomarkers Prev 17: 15-26.
54. Hein DW, (2006) N-acetyltransferase 2 genetic polymorphism: effects of carcinogen and haplotype on urinary bladder cancer risk. Oncogene 25: 1649-1658.
55. Garcia-Closas M, Malats N, Silverman D, Dosemeci M, Kogevinas M, et al. (2005) NAT2 slow acetylation, GSTM1 null genotype, and risk of bladder cancer: results from the Spanish Bladder Cancer Study and meta-analyses. Lancet 366: 649-659.
56. Woolf B, (1955) On estimating the relation between blood group and disease. Ann Hum Genet 19: 251-253.
57. Higgins JP, Thompson SG, (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 21: 1539-1558.
58. Mantel N, Haenszel W, (1959) Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 22: 719-748.
59. DerSimonian R, Laird N, (1986) Meta-analysis in clinical trials. Control Clin Trials 7: 177-188.
60. Egger M, Davey Smith G, Schneider M, Minder C, (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315: 629-634.