N-acetyltransferase (NAT) 2 acetylator status and age of tumour onset in patients with sporadic and familial, microsatellite stable (MSS) colorectal cancer

International Journal of Colorectal Disease

Volumn 22, Issue 2, 2007, Pages 137-143

  Pistorius, Steffen ^a   Goergens, Heike ^a   Engel, Christoph ^b   Plaschke, Jens ^a   Krueger, Stefan ^a   Hoehl, Ruth ^a   Saeger, Hans Detlev ^a   Schackert, Hans K ^a  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^b UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

Bethesda criteria; Familial colorectal cancer; Microsatellite instability; NAT2; Sporadic colorectal cancer

Indexed keywords

ARYLAMINE ACETYLTRANSFERASE;

ACETYLATOR PHENOTYPE; ADULT; AGED; ARTICLE; CANCER PATIENT; CANCER RISK; COLORECTAL CANCER; CONTROLLED STUDY; FAMILIAL CANCER; FEMALE; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MICROSATELLITE INSTABILITY; ONSET AGE; PRIORITY JOURNAL; PROPORTIONAL HAZARDS MODEL; SEX DIFFERENCE; STATISTICAL SIGNIFICANCE;

ACETYLATION; ADULT; AGE OF ONSET; AGED; ARYLAMINE N-ACETYLTRANSFERASE; COLORECTAL NEOPLASMS; FEMALE; HUMANS; MALE; MICROSATELLITE INSTABILITY; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 33845709205     PISSN: 01791958     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00384-006-0171-0     Document Type: Article

References (52)

1. Hein DW (2002) Molecular genetics and function of NAT1 and NAT2: Role in aromatic amine metabolism and carcinogenesis. Mutat Res 506-507:65-77
2. Lin HJ, Han CY, Lin BK, Hardy S (1993) Slow acetylator mutations in the human polymorphic N-acetyltransferase gene in 786 Asians, blacks, Hispanics, and whites: Application to metabolic epidemiology. Am J Hum Genet 52:827-834
3. Chen K, Jiang QT, He HQ (2005) Relationship between metabolic enzyme polymorphism and colorectal cancer. World J Gastroenterol 11:331-335
4. Slattery ML, Potter JD, Samowitz W, Bigler J, Caan B, Leppert M (1998) NAT2, GSTM-1, cigarette smoking, and risk of colon cancer. Cancer Epidemiol Biomarkers Prev 7:1079-1084
5. Kampman E, Slattery ML, Bigler J, Leppert M, Samowitz W, Caan BJ, Potter JD (1999) Meat consumption, genetic susceptibility, and colon cancer risk: A United States multicenter case-control study. Cancer Epidemiol Biomarkers Prev 8:15-24
6. Ye Z, Parry JM (2002) Meta-analysis of 20 case-control studies on the N-acetyltransferase 2 acetylation status and colorectal cancer risk. Med Sci Monit 8:CR558-CR565
7. Roberts-Thomson IC, Ryan P, Khoo KK, Hart WJ, McMichael AJ, Butler RN (1996) Diet, acetylator phenotype, and risk of colorectal neoplasia. Lancet 347:1372-1374
8. Slattery ML, Edwards S, Curtin K, Schaffer D, Neuhausen S (2003) Associations between smoking, passive smoking, GSTM-1, NAT2, and rectal cancer. Cancer Epidemiol Biomarkers Prev 12:882-889
9. Chan AT, Tranah GJ, Giovannucci EL, Willett WC, Hunter DJ, Fuchs CS (2005) Prospective study of N-acetyltransferase-2 genotypes, meat intake, smoking and risk of colorectal cancer. Int J Cancer 115:648-652
10. Chenevix-Trench G, Young J, Coggan M, Board P (1995) Glutathione S-transferase M1 and T1 polymorphisms: Susceptibility to colon cancer and age of onset. Carcinogenesis 16:1655-1657
11. Deakin M, Elder J, Hendrickse C, Peckham D, Baldwin D, Pantin C, Wild N, Leopard P, Bell DA, Jones P, Duncan H, Brannigan K, Alldersea J, Fryer AA, Strange RC (1996) Glutathione S-transferase GSTT1 genotypes and susceptibility to cancer: Studies of interactions with GSTM1 in lung, oral, gastric and colorectal cancers. Carcinogenesis 17:881-884
12. Katoh T, Nagata N, Kuroda Y, Itoh H, Kawahara A, Kuroki N, Ookuma R, Bell DA (1996) Glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) genetic polymorphism and susceptibility to gastric and colorectal adenocarcinoma. Carcinogenesis 17:1855-1859
13. Gertig DM, Stampfer M, Haiman C, Hennekens CH, Kelsey K, Hunter DJ (1998) Glutathione S-transferase GSTM1 and GSTT1 polymorphisms and colorectal cancer risk: A prospective study. Cancer Epidemiol Biomarkers Prev 7:1001-1005
14. Welfare M, Monesola Adeokun A, Bassendine MF, Daly AK (1999) Polymorphisms in GSTP1, GSTM1, and GSTT1 and susceptibility to colorectal cancer. Cancer Epidemiol Biomarkers Prev 8:289-292
15. Zhang H, Ahmadi A, Arbman G, Zdolsek J, Carstensen J, Nordenskjold B, Soderkvist P, Sun XF (1999) Glutathione S-transferase T1 and M1 genotypes in normal mucosa, transitional mucosa and colorectal adenocarcinoma. Int J Cancer 84:135-138
16. Loktionov A, Watson MA, Gunter M, Stebbings WS, Speakman CT, Bingham SA (2001) Glutathione-S-transferase gene polymorphisms in colorectal cancer patients: Interaction between GSTM1 and GSTM3 allele variants as a risk-modulating factor. Carcinogenesis 22:1053-1060
17. Yokoyama A, Muramatsu T, Ohmori T, Yokoyama T, Okuyama K, Takahashi H, Hasegawa Y, Higuchi S, Maruyama K, Shirakura K, Ishii H (1998) Alcohol-related cancers and aldehyde dehydrogenase-2 in Japanese alcoholics. Carcinogenesis 19:1383-1387
18. Murata M, Tagawa M, Watanabe S, Kimura H, Takeshita T, Morimoto K (1999) Genotype difference of aldehyde dehydrogenase 2 gene in alcohol drinkers influences the incidence of Japanese colorectal cancer patients. Jpn J Cancer Res 90:711-719
19. Curtin K, Bigler J, Slattery ML, Caan B, Potter JD, Ulrich CM (2004) MTHFR C677T and A1298C polymorphisms: Diet, estrogen, and risk of colon cancer. Cancer Epidemiol Biomarkers Prev 13:285-292
20. Chen J, Ma J, Stampfer MJ, Palomeque C, Selhub J, Hunter DJ (2002) Linkage disequilibrium between the 677C>T and 1298A>C polymorphisms in human methylenetetrahydrofolate reductase gene and their contributions to risk of colorectal cancer. Pharmacogenetics 12:339-342
21. Plaschke J, Schwanebeck U, Pistorius S, Saeger HD, Schackert HK (2003) Methylenetetrahydrofolate reductase polymorphisms and risk of sporadic and hereditary colorectal cancer with or without microsatellite instability. Cancer Lett 191:179-185
22. Keku T, Millikan R, Worley K, Winkel S, Eaton A, Biscocho L, Martin C, Sandler R (2002) 5,10-Methylenetetrahydrofolate reductase codon 677 and 1298 polymorphisms and colon cancer in African Americans and whites. Cancer Epidemiol Biomarkers Prev 11:1611-1621
23. Shannon B, Gnanasampanthan S, Beilby J, Iacopetta B (2002) A polymorphism in the methylenetetrahydrofolate reductase gene predisposes to colorectal cancers with microsatellite instability. Gut 50:520-524
24. Sivaraman L, Leatham MP, Yee J, Wilkens LR, Lau AF, Le Marchand L (1994) CYP1A1 genetic polymorphisms and in situ colorectal cancer. Cancer Res 54:3692-3695
25. Butler WJ, Ryan P, Roberts-Thomson IC (2001) Metabolic genotypes and risk for colorectal cancer. J Gastroenterol Hepatol 16:631-635
26. Fritsche E, Bruning T, Jonkmanns C, Ko Y, Bolt HM, Abel J (1999) Detection of cytochrome P450 1B1 Bfr I polymorphism: Genotype distribution in healthy German individuals and in patients with colorectal carcinoma. Pharmacogenetics 9:405-408
27. Kiss I, Sandor J, Pajkos G, Bogner B, Hegedus G, Ember I (2000) Colorectal cancer risk in relation to genetic polymorphism of cytochrome P450 1A1, 2E1, and glutathione-S-transferase M1 enzymes. Anticancer Res 20:519-522
28. Slattery ML, Samowitz W, Ballard L, Schaffer D, Leppert M, Potter JD (2001) A molecular variant of the APC gene at codon 1822: Its association with diet, lifestyle, and risk of colon cancer. Cancer Res 61:1000-1004
29. Frayling IM, Beck NE, Ilyas M, Dove-Edwin I, Goodman P, Pack K, Bell JA, Williams CB, Hodgson SV, Thomas HJ, Talbot IC, Bodmer WF, Tomlinson IP (1998) The APC variants I1307K and E1317Q are associated with colorectal tumors, but not always with a family history. Proc Natl Acad Sci USA 95:10722-10727
30. Bell DA, Stephens EA, Castranio T, Umbach DM, Watson M, Deakin M, Elder J, Hendrickse C, Duncan H, Strange RC (1995) Polyadenylation polymorphism in the acetyltransferase 1 gene (NAT1) increases risk of colorectal cancer. Cancer Res 55:3537-3542
31. Chen J, Stampfer MJ, Hough HL, Garcia-Closas M, Willett WC, Hennekens CH, Kelsey KT, Hunter DJ (1998) A prospective study of N-acetyltransferase genotype, red meat intake, and risk of colorectal cancer. Cancer Res 58:3307-3311
32. Katoh T, Boissy R, Nagata N, Kitagawa K, Kuroda Y, Itoh H, Kawamoto T, Bell DA (2000) Inherited polymorphism in the N-acetyltransferase 1 (NAT1) and 2 (NAT2) genes and susceptibility to gastric and colorectal adenocarcinoma. Int J Cancer 85:46-49
33. Lang NP, Butler MA, Massengill J, Lawson M, Stotts RC, Hauer-Jensen M, Kadlubar FF (1994) Rapid metabolic phenotypes for acetyltransferase and cytochrome P4501A2 and putative exposure to food-borne heterocyclic amines increase the risk for colorectal cancer or polyps. Cancer Epidemiol Biomarkers Prev 3:675-682
34. Ilett KF, David BM, Detchon P, Castleden WM, Kwa R (1987) Acetylation phenotype in colorectal carcinoma. Cancer Res 47:1466-1469
35. Ladero JM, Gonzalez JF, Benitez J, Vargas E, Fernandez MJ, Baki W, Diaz-Rubio M (1991) Acetylator polymorphism in human colorectal carcinoma. Cancer Res 51:2098-2100
36. Hubbard AL, Harrison DJ, Moyes C, Wyllie AH, Cunningham C, Mannion E, Smith CA (1997) N-acetyltransferase 2 genotype in colorectal cancer and selective gene retention in cancers with chromosome 8p deletions. Gut 41:229-234
37. Welfare MR, Cooper J, Bassendine MF, Daly AK (1997) Relationship between acetylator status, smoking, and diet and colorectal cancer risk in the north-east of England. Carcinogenesis 18:1351-1354
38. Gil JP, Lechner MC (1998) Increased frequency of wild-type arylamine-N-acetyltransferase allele NAT2*4 homozygotes in Portuguese patients with colorectal cancer. Carcinogenesis 19:37-41
39. Krontiris TG, Devlin B, Karp DD, Robert NJ, Risch N (1993) An association between the risk of cancer and mutations in the HRAS1 minisatellite locus. N Engl J Med 329:517-523
40. Klingel R, Mittelstaedt P, Dippold WG, Meyer zum Buschenfelde KH (1991) Distribution of Ha-ras alleles in patients with colorectal cancer and Crohn's disease. Gut 32:1508-1513
41. Gosse-Brun S, Sauvaigo S, Daver A, Larra F, Kwiatkowski F, Bignon YJ, Bernard-Gallon D (1998) Association between H-ras minisatellite and colorectal cancer risk. Anticancer Res 18:2611-2616
42. Rodriguez-Bigas MA, Boland CR, Hamilton SR, Henson DE, Jass JR, Khan PM, Lynch H, Perucho M, Smyrk T, Sobin L, Srivastava S (1997) A National Cancer Institute Workshop on Hereditary Nonpolyposis Colorectal Cancer Syndrome: Meeting highlights and Bethesda guidelines. J Natl Cancer Inst 89:1758-1762
43. Pistorius SR, Kruppa C, Haas S, Plaschke J, Kruger S, Bulitta CJ, Nagel M, Saeger HD, Schackert HK (2000) Clinical consequences of molecular diagnosis in families with mismatch repair gene germline mutations. Int J Colorectal Dis 15:255-263
44. Gorgens H, Fitze G, Roesner D, Schackert HK (2004) One-step analysis of ten functional haplotype combinations of the basic RET promoter with a LightCycler assay. Clin Chem 50:1693-1695
45. Cascorbi I, Roots I (1999) Pitfalls in N-acetyltransferase 2 genotyping. Pharmacogenetics 9:123-127
46. Heinimann K, Scott RJ, Chappuis P, Weber W, Muller H, Dobbie Z, Hutter P (1999) N-acetyltransferase 2 influences cancer prevalence in hMLH1/hMSH2 mutation carriers. Cancer Res 59:3038-3040
47. Frazier ML, O'Donnell FT, Kong S, Gu X, Campos I, Luthra R, Lynch PM, Amos CI (2001) Age-associated risk of cancer among individuals with N-acetyltransferase 2 (NAT2) mutations and mutations in DNA mismatch repair genes. Cancer Res 61:1269-1271
48. Lamberti C, Jungck M, Laarmann M, Knapp M, Caspari R, Friedl W, Sauerbruch T, Propping P, Kruse R (2002) Arylamine N-acetyltransferase type 2 and glutathione S-transferases M1 and T1 polymorphisms in familial adenomatous polyposis. Pharmacogenetics 12:49-54
49. Crabtree MD, Fletcher C, Churchman M, Hodgson SV, Neale K, Phillips RK, Tomlinson IP (2004) Analysis of candidate modifier loci for the severity of colonic familial adenomatous polyposis, with evidence for the importance of the N-acetyl transferases. Gut 53:271-276
50. Slattery ML, Edwards SL, Samowitz W, Potter J (2000) Associations between family history of cancer and genes coding for metabolizing enzymes (United States). Cancer Causes Control 11:799-803
51. Slattery ML, Potter JD, Ma KN, Caan BJ, Leppert M, Samowitz W (2000) Western diet, family history of colorectal cancer, NAT2, GSTM-1 and risk of colon cancer. Cancer Causes Control 11:1-8
52. Slattery ML, Curtin K, Ma K, Schaffer D, Potter J, Samowitz W (2002) GSTM-1 and NAT2 and genetic alterations in colon tumors. Cancer Causes Control 13:527-534