Rapid identification of low level glycation sites in recombinant antibodies by isotopic labeling with 13C 6-reducing sugars

Analytical Chemistry

Volumn 84, Issue 5, 2012, Pages 2313-2320

  Zhang, Jennifer ^a   Zhang, Taylor ^a   Jiang, Lihua ^b   Hewitt, Daniel ^a   Huang, Yungfu ^a   Kao, Yung Hsiang ^a   Katta, Viswanatham ^a  

^a GENENTECH INC   (United States)

^b Thermo Fisher Scientific   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCATION; HIGH CONCENTRATION; ISOTOPIC LABELING; LARGE DATA; LOW LEVEL; MASS ACCURACY; MOLECULAR IONS; ORBITRAP; PRESENCE/ABSENCE; RAPID IDENTIFICATION; RECOMBINANT ANTIBODY; REDUCING SUGARS; SITE-SPECIFIC; TRYPTIC PEPTIDES; WORK-FLOWS;

GLYCOSYLATION; PEPTIDES; SUGARS;

ANTIBODIES;

ANTIBODY; CARBOHYDRATE; CARBON; GLYCOPEPTIDE; RECOMBINANT PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; CHEMISTRY; GENETICS; GLYCOSYLATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOTOPE LABELING; MASS SPECTROMETRY; METABOLISM; OXIDATION REDUCTION REACTION;

AMINO ACID SEQUENCE; ANTIBODIES; CARBOHYDRATES; CARBON ISOTOPES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GLYCOPEPTIDES; GLYCOSYLATION; ISOTOPE LABELING; OXIDATION-REDUCTION; RECOMBINANT PROTEINS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 84863258197     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac202995x     Document Type: Article

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