Mitochondrial reactive oxygen species mediate hypoxic down-regulation of hERG channel protein

Biochemical and Biophysical Research Communications

Volumn 373, Issue 2, 2008, Pages 309-314

  Nanduri, Jayasri ^a   Wang, Ning ^a   Bergson, Pamela ^a   Yuan, Guoxiang ^a   Ficker, Eckhard ^b   Prabhakar, Nanduri R ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

hERG; Hypoxia; Mitochondria; Mitochondrial reactive oxygen species; NADPH oxidase; Proteasome; ROS

Indexed keywords

ANTIOXIDANT; ENZYME INHIBITOR; MITOCHONDRIAL DNA; OXIDIZING AGENT; POTASSIUM CHANNEL HERG; PROTEASOME; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

ALPHA CHAIN; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HYPOXIA; MITOCHONDRION; MOUSE; NONHUMAN; POTASSIUM CONDUCTANCE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RNA TRANSLATION;

ANAEROBIOSIS; ANTIOXIDANTS; CELL LINE; DOWN-REGULATION; ETHER-A-GO-GO POTASSIUM CHANNELS; HUMANS; MITOCHONDRIA; OXYGEN; PROTEIN BIOSYNTHESIS; REACTIVE OXYGEN SPECIES;

EID: 46049103344     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.06.028     Document Type: Article

References (21)

1. Kemp P.J., and Peers C. Oxygen sensing by ion channels. Essays Biochem. 43 (2007) 77-90 Review
2. + channel in rat PC12 cells by hypoxia. J. Physiol. 502 (1997) 293-305
3. Wang J., Weigand L., Wang W., Sylvester J.T., and Shimoda L.A. Chronic hypoxia inhibits Kv channel gene expression in rat distal pulmonary artery. Am. J. Physiol. Lung Cell. Mol. Physiol. 288 (2005) L1049-L1058
4. Peers C., and Kemp P.J. Ion channel regulation by chronic hypoxia in models of acute oxygen sensing. Cell Calcium 36 (2004) 341-348 Review
5. Sanguinetti M.C., Jiang C., Curran M.E., and Keating M.Y. A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr. Cell 81 (1995) 299-307
6. Curran M.E., Splawski I., Timothy K.W., Vincent G.M., Green E.D., and Keating M.T. A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome. Cell 80 (1995) 795-803
7. Overholt J.L., Ficker E., Yang T., Shams H., Bright G.R., and Prabhakar N.R. HERG-like potassium current regulates the resting membrane potential in glomus cells of the rabbit carotid body. J. Neurophysiol. 83 (2000) 1150-1157
8. Kim I., Boyle K.M., and Carroll J.L. Postnatal development of E-4031-sensitive potassium current in rat carotid chemoreceptor cells. J. Appl. Physiol. 98 (2005) 1469-1477
9. Fontana L., D'Amico M., Crociani O., Biagiotti T., Solazzo M., Rosati B., Arcangeli A., Wanke E., and Olivotto M. Long-term modulation of HERG channel gating in hypoxia. Biochem. Biophys. Res. Commun. 286 (2001) 857-862
10. Guzy R.D., and Schumacker P.T. Oxygen sensing by mitochondria at complex III: the paradox of increased reactive oxygen species during hypoxia. Exp. Physiol. 91 (2006) 807-819 Review
11. + channels by reactive oxygen species. Proc. Natl. Acad. Sci. USA 94 (1997) 11698-11703
12. Berube J., Caouette D., and Daleau P. Hydrogen peroxide modifies the kinetics of HERG channel expressed in a mammalian cell line. J. Pharmacol. Exp. Ther. 297 (2001) 96-102
13. Ficker E., Kuryshev Y.A., Dennis A.T., Obejero-Paz C., Wang L., Hawryluk P., Wible B.A., and Brown A.M. Mechanisms of arsenic-induced prolongation of cardiac depolarization. Mol. Pharmacol. 66 (2004) 33-44
14. + channel function as a mechanism for insulin treatment of abnormal QT prolongation and associated arrhythmias in diabetic rabbits. Am. J. Physiol. Heart Circ. Physiol. 291 (2006) H1446-H1455
15. Levraut J., Iwase H., Shao Z.H., Vanden Hoek T.L., and Schumacker P.T. Cell death during ischemia: relationship to mitochondrial depolarization and ROS generation. Am. J. Physiol. Heart Circ. Physiol. 284 (2003) 549-558
16. Ramanathan L., Gozal D., and Siegel J.M. Antioxidant responses to chronic hypoxia in the rat cerebellum and pons. J. Neurochem. 93 (2005) 47-52
17. Gong Q., Keeney D.R., Molinari M., and Zhou Z. Degradation of trafficking-defective long QT syndrome type II mutant channels by the ubiquitin-proteasome pathway. J. Biol. Chem. 280 (2005) 19419-19425
18. van den Beucken T., Koritzinsky M., and Wouters B.G. Translational control of gene expression during hypoxia. Cancer Biol. Ther. 5 (2006) 749-755 Review
19. 2-sensor in resistance artery smooth muscle cells. J. Mol. Cell. Cardiol. 37 (2004) 1119-1136 Review
20. Bell E.L., Klimova T.A., Eisenbart J., Moraes C.T., Murphy M.P., Budinger G.R., and Chandel N.S. The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production. J. Cell Biol. 177 (2007) 1029-1036
21. Taylor B.L., and Zhulin I.B. PAS domains: internal sensors of oxygen, redox potential, and light. Microbiol. Mol. Biol. Rev. 63 (1999) 479-506