Protective effects of curcumin in APPSwe transfected SH-SY5Y cells

Neural Regeneration Research

Volumn 7, Issue 6, 2012, Pages 405-412

  Yin, Wenke ^a   Zhang, Xiong ^b   Li, Yu ^b  

^a AFFILIATED HOSPITAL OF NORTH SICHUAN MEDICAL COLLEGE   (China)

^b CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

Alzheimer's disease; Curcumin; Heme oxygenase 1; Heme oxygenase 2; Neural regeneration; Phosphatidylinositol 3 kinase signaling pathway

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; AMYLOID BETA PROTEIN [1-40]; AMYLOID BETA PROTEIN [1-42]; CURCUMIN; FERRITIN; HEME OXYGENASE 1; HEME OXYGENASE 2; HYDROGEN PEROXIDE; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; APPSWE PLASMID; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; NEUROPROTECTION; PLASMID; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

EID: 84863232696     PISSN: 16735374     EISSN: 18767958     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Jucker M, Walker LC. Pathogenic protein seeding in Alzheimer disease and other neurodegenerative disorders. Ann Neurol. 2011;70(4):532-540.
2. Cuadrado A, Rojo AI. Heme oxygenase-1 as a therapeutic target in neurodegenerative diseases and brain infections. Curr Pharm Des. 2008;14(5):429-442.
3. Robert T, Kinobe, Ryan A, et al. Inhititors of heme oxygenase-carbon monoxide system: on the doorstep of clinic?. Can J Physiol. Pharmacol. 2008;86(9):577-599.
4. Maheshwari RK, Singh AK, Gaddipati J, et al. Multiple biological activaties of curcumin: a short review. Life Sci. 2006;78(18): 2081-2087.
5. Baghdasaryan A, Claudel T, Kosters A, et al. Curcumin improves sclerosing cholangitis in Mdr2-/- mice by inhibiting of cholangiocyte inflammatory response and portal myofibroblast proliferation. Gut. 2010;59(4):521-530.
6. Moon DO, Kim MO, Choi YH, et al. Curcumin attenuates inflammatory response IL-1beta-induced human synovial fibroblasts and collagen-induced arthritis in mouse model. Int Immunopharmacol. 2010;10(5):605-610.
7. Tanwar V, Sachdeva J, Golechha M, et al. Curcumin protects rat myocardium against isoproterenol-induced ischemic injury: Attenuation of ventricular dysfunction through increased expression of Hsp27 along with strengthening antioxidant defense system. J Cardiovasc Pharmacol. 2010;55(4):377-384.
8. Belkacemi A, Doggui S, Dao L, et al. Challenges associated with curcumin therapy in Alzheimer disease. Expert Rev Mol Med. 2011;4(13):34.
9. Jeong SO, Oh GS, Ha HY, et al. Dimethoxycurcumin, a Synthetic Curcumin Analogue, Induces Heme Oxygenase-1 Expression through Nrf2 Activation in RAW264.7 Macrophages. J Clin Biochem Nutr. 2009;44(1):79-84.
10. Atamna H, Boyle K. Amyloid-β peptide binds with heme to form a peroxidase: Relationship to the cytopathologies of Alzheimer's disease. Proc Natl Acad Sci U S A. 2006;103(9):3381-3386.
11. Hamaguchi T, Ono K, Murase A, et al. Phenolic compounds prevent Alzheimer's pathology through different effects on the amyloid-beta aggregation pathway. Am J Pathol. 2009;175(6): 2557-2565.
12. Hong HS, Rana S, Barrigan L, et al. Inhibition of Alzheimer's amyloid toxicity with a tricyclic pyrone molecule in vitro and in vivo. J Neurochem. 2009;108(4):1097-1108.
13. McNally SJ, Harrison EM, Ross JA, et al. Curcumin induces heme oxygenase 1 through generation of reactive oxygen species, p38 activation and phosphatase inhibition. Int J Mol Med. 2007;19(1): 165-172.
14. Balogun E, Hoque M, Gong P, et al. Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element. Biochem J. 2003;371(3): 887-895.
15. Hashim A, Wang L, Juneja K, et al. Vitamin B6s inhibit oxidative stress caused by Alzheimer's disease-related Cu(II)-β-amyloid complexes-cooperative action of phospho-moiety. Bioorg Med Chem Lett. 2011;21(21):6430-6432.
16. Wang HM, Zhao YX, Zhang S, et al. PPAR-gamma agonist curcumin reduces the amyloid-beta-stimulated inflammatory responses in primary astrocytes. J Alzheimers Dis. 2010;20(4): 1189-1199.
17. Zhang C, Browne A, Child D, et al. Curcumin decreases amyloid beta-peptide levels by attenuating the maturation of amyloid-beta precursor protein. J Biol Chem. 2010;285(37):28472-28480.
18. Anthony SG, Schipper HM, Tavares R, et al. Stress protein expression in the Alzheimer-diseased choroid plexus. J Alzheimers Dis. 2003;5(3):171-177.
19. Regan RF, Chen J, Benvenisti-Zarom L. Heme oxygenase-2 deletion attenuates oxidative stress in neurons exposed to extracellular hemin. BMC Neurosci. 2004;17(5):34.
20. Ha YM, Ham SA, Kim YM, et al. β1-adrenergic receptor-mediated HO-1 induction, via PI3K and p38 MAPK, by isoproterenol in RAW 264.7 cells leads to inhibition of HMGB1 release in LPS-activated RAW 264.7 cells and increases in survival rate of CLP-induced septic mice. Biochem Pharmacol. 2011;82(7):769-777.
21. Li MH, Jang JH, Na HK, et al. Carbon monoxide produced by heme oxygenase-1 in response to nitrosative stress induces expression of glutamatecysteine ligase in PC12 cells via activation of phosphatidylinositol 3-kinase and Nrf2 signaling. J Biol Chem. 2007;282(39):28577-28586.
22. Goel A, Kunnumakkara AB, Aggarwal BB. Curcumin as "Curecumin": from kitchen to clinic. Biochem Pharmacol. 2008; 75(4):787-809.
23. Kim KC, Kang KA, Zhang R, et al. Up-regulation of Nrf2-mediated heme oxygenase-1 expression by eckol, a phlorotannin compound, through activation of Erk and PI3K/Akt. Int J Biochem Cell Biol. 2010;42(2):297-305.
24. Zhang HM, Zhang X, Li Y. The regulation of curcumin on the amyloidogentic pathway of app in alzheimer's disease. Zhongguo Yaolixue Tongbao. 2009;25(3):421-426.