Curcumin protects rat myocardium against isoproterenol-induced ischemic injury: Attenuation of ventricular dysfunction through increased expression of hsp27 alongwith strengthening antioxidant defense system

Journal of Cardiovascular Pharmacology

Volumn 55, Issue 4, 2010, Pages 377-384

  Tanwar, Vineeta ^a   Sachdeva, Jaspreet ^a   Golechha, Mahaveer ^a   Kumari, Santosh ^b   Arya, Dharamvir Singh ^a  

^a All India Institute of Medical Sciences   (United States)

^b INDIAN AGRICULTURAL RESEARCH INSTITUTE   (India)

Author keywords

Antioxidant; Curcumin; Free radicals; Hsp27; Isoproterenol; Ventricular function

Indexed keywords

CATALASE; CREATINE KINASE MB; CURCUMIN; GLUTATHIONE; HEAT SHOCK PROTEIN 27; ISOPRENALINE; LACTATE DEHYDROGENASE; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; ANTIOXIDANT; HSPB1 PROTEIN, RAT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTERIAL PRESSURE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; HEART FUNCTION; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART MUSCLE CONTRACTILE FORCE; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HEART RATE; HEART VENTRICLE FUNCTION; HEMODYNAMIC PARAMETERS; LIPID PEROXIDATION; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; WESTERN BLOTTING; ANIMAL; BLOOD PRESSURE; CHEMICALLY INDUCED; DRUG EFFECTS; ENZYMOLOGY; HEART; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE; METABOLISM; MYOCARDIAL ISCHEMIA; PATHOPHYSIOLOGY; PHYSIOLOGY; PREVENTION AND CONTROL; WISTAR RAT;

ANIMALS; ANTIOXIDANTS; BLOOD PRESSURE; CATALASE; CREATINE KINASE, MB FORM; CURCUMIN; GLUTATHIONE; HEART; HEART RATE; HSP27 HEAT-SHOCK PROTEINS; ISOPROTERENOL; L-LACTATE DEHYDROGENASE; LIPID PEROXIDATION; MALE; MYOCARDIAL ISCHEMIA; MYOCARDIUM; RATS; RATS, WISTAR; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCES; VENTRICULAR DYSFUNCTION, LEFT;

EID: 77951711190     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/FJC.0b013e3181d3da01     Document Type: Article

References (62)

1. Chugh SS, Reinier K, Teodorescu C, et al. Epidemiology of sudden cardiac death: clinical and research implications. Prog Cardiovasc Dis. 2008;51:213-228.
2. Klein L, Gheorghiade M. Coronary artery disease and prevention of heart failure. Med Clin North Am. 2004;88:1209-1235.
3. Singh K, Communal C, Sawyer DB, et al. Adrenergic regulation of myocardial apoptosis. Cardiovasc Res. 2000;45:713-719.
4. Mann DL, Kent RL, Parsons B, et al. Adrenergic effects on the biology of the adult mammalian cardiocyte. Circulation. 1992;85:790-804.
5. Taylor PB, Tang Q. Development of isoproterenol-induced cardiac hypertrophy. Can J Physiol Pharmacol. 1984;62:384-389.
6. Milei J, Núñez RG, Rapaport M. Pathogenesis of isoprenaline-induced myocardial lesions: its relation to human 'coagulative myocytolysis'. Cardiology. 1978;63:139-151.
7. Grimm D, Elsner D, Schunkert H, et al. Development of heart failure following isoproterenol administration in the rat: role of the reninangiotensin system. Cardiovasc Res. 1998;37:91-100.
8. Todd GL, Baroldi G, Pieper GM, et al. Experimental catecholamineinduced myocardial necrosis I. Morphology, quantification and regional distribution of acute contraction band lesions. J Mol Cell Cardiol. 1985; 17:317-338.
9. Shlafer M, Myer CL, Adkins S. Mitochondrial hydrogen peroxide generation and activities of glutathione peroxide and superoxide dismutase following global ischemia. J Mol Cell Cardiol. 1987;19: 1195-1206.
10. Kehrer JP. Free radicals as mediators of tissue injury and disease. Crit Rev Toxicol. 1993;23:21-48.
11. Kramer JH, Misik V,WeglickiWB. Lipid peroxidation derived free radical production and postischemic myocardial reperfusion injury. Ann N Y Acad Sci. 1994;723:180-186.
12. Delogu G, Signore M, Mechelli A, et al. Heat shock proteins and their role in heart injury. Curr Opin Crit Care. 2002;8:411-416.
13. Christians ES, Yan LJ, Benjamin IJ. Heat shock factor 1 and heat shock proteins: Critical partners in protection against acute cell injury. Crit Care Med. 2002;30(Suppl 1):S43-S50.
14. Pirkkala L, Nykänen P, Sistonen L. Roles of the heat shock transcription factors in regulation of the heat shock response and beyond. FASEB J. 2001;15:1118-1131.
15. Zhao Y,WangW, Qian L. Hsp70 may protect cardiomyocytes from stressinduced injury by inhibiting Fas-mediated apoptosis. Cell Stress Chaperones. 2007;12:83-95.
16. Vander Heide RS. Increased expression of HSP27 protects canine myocytes from simulated ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 2002;282:H935-H941.
17. Feng JY, Liu ZQ. Phenolic and enolic hydroxyl groups in curcumin: which plays the major role in scavenging radicals? J Agric Food Chem. 2009. [Epub ahead of print].
18. IqbalM,OkazakiY,OkadaS.Curcuminattenuatesoxidativedamageinanimals treated with a renal carcinogen, ferric nitrilotriacetate (Fe-NTA): implications for cancer prevention. Mol Cell Biochem. 2009;324:157-164.
19. Hong J, Bose M, Ju J, et al. Modulation of arachidonic acid metabolism by curcumin and related beta-diketone derivatives: effects on cytosolic phospholipase A(2), cyclooxygenases and 5-lipoxygenase. Carcinogenesis. 2004;25:1671-1679.
20. Thangapazham RL, Sharma A, Maheshwari RK.Multiple molecular targets in cancer chemoprevention by curcumin. AAPS J. 2006;8:E443-E449.
21. Kuttan G, Kumar KB, Guruvayoorappan C, et al. Antitumor, antiinvasion, and antimetastatic effects of curcumin. Adv Exp Med Biol. 2007; 595:173-184.
22. Marín YE, Wall BA, Wang S, et al. Curcumin downregulates the constitutive activity of NF-kappaB and induces apoptosis in novel mouse melanoma cells. Melanoma Res. 2007;17:274-283.
23. Miriyala S, Panchatcharam M, Rengarajulu P. Cardioprotective effects of curcumin. Adv Exp Med Biol. 2007;595:359-377.
24. Srivastava G, Mehta JL. Currying the heart: curcumin and cardioprotection. J Cardiovasc Pharmacol Ther. 2009;14:22-27.
25. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 1979;95:351-358.
26. Cabaud PG, Wroblewski F. Colorimetric measurements of lactic dehydrogenase activity of body fluids. Am J Clin Pathol. 1958;30:234-236.
27. Moron MS, Depierre J, Manmerik B. Level of glutathione, glutathione reductase and glutathione-S-transferase activity in rat lung and liver. Biochem Biophys Acta. 1979;582:67-78.
28. Marklund S, Marklund G. Involvement of the superoxide anion radical in the autooxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem. 1974;47:469-474.
29. Aebi H. Catalase in vitro. Methods Enzymol. 1984;105:121-126.
30. Brown DD, Christine KS, Showell C, et al. Small heat shock protein Hsp27 is required for proper heart tube formation. Genesis. 2007;45: 667-678.
31. Bennardini F, Wrzosek A, Chiesi M. Alpha B-crystallin in cardiac tissue. Association with actin and desmin filaments. Circ Res. 1992;71: 288-294.
32. Liu P, Xiang JZ, Zhao L, et al. Effect of beta2-adrenergic agonist clenbuterol on ischemia/reperfusion injury in isolated rat hearts and cardiomyocyte apoptosis induced by hydrogen peroxide. Acta Pharmacol Sin. 2008;29:661-669.
33. Osadchii OE, Norton GR, McKechnie R, et al. Cardiac dilatation and pump dysfunction without intrinsic myocardial systolic failure following chronic beta-adrenoreceptor activation. Am J Physiol Heart Circ Physiol. 2007;292:H1898-H1905.
34. Teerlink JR, Pfeffer JM, Pfeffer MA. Progressive ventricular remodeling in response to diffuse isoproterenol-induced myocardial necrosis in rats. Circ Res. 1994;75:105-113.
35. Yeager JC, Iams SG. The hemodynamics of isoproterenol-induced cardiac failure in the rat. Circ Shock. 1981;8:151-163.
36. Steenbergen C, Fralix TA, Murphy E. Role of increased cytosolic free calcium concentration in myocardial ischemic injury. Basic Res Cardiol. 1993;88:456-470.
37. Zucchi R, Ghelardoni S, Evangelista S. Biochemical basis of ischemic heart injury and of cardioprotective interventions. Curr Med Chem. 2007; 14:1619-1637.
38. Remião F, Carmo H, Carvalho F, et al. Copper enhances isoproterenol toxicity in isolated rat cardiomyocytes: effects on oxidative stress. Cardiovasc Toxicol. 2001;1:195-204.
39. Ostling P, Björk JK, Roos-Mattjus P, et al. Heat shock factor 2 (HSF2) contributes to inducible expression of hsp genes through interplay with HSF1. J Biol Chem. 2007;282:7077-7086.
40. Pirkkala L, Nykanen P, Sistonen L. Roles of the heat shock transcription factors in regulation of the heat shock response and beyond. FASEB J. 2001;15:1118-1131.
41. Dunsmore KE, Chen PG, Wong HR. Curcumin, a medicinal herbal compound capable of inducing the heat shock response. Crit Care Med. 2001;29:2199-2204.
42. Kato K, Ito H, Kamei K, et al. Stimulation of the stress-induced expression of stress proteins by curcumin in cultured cells and in rat tissues in vivo. Cell Stress Chaperones. 1998;3:152-160.
43. Grant CM. Role of the glutathione/glutaredoxin and thioredoxin systems in yeast growth and response to stress conditions. Mol Microbiol. 2001; 39:533-541.
44. Purdom-Dickinson SE, Lin Y, Dedek M, et al. Induction of antioxidant and detoxification response by oxidants in cardiomyocytes: evidence from gene expression profiling and activation of Nrf2 transcription factor. J Mol Cell Cardiol. 2007;42:159-176.
45. Purdom-Dickinson SE, Sheveleva EV, et al. Translational control of nrf2 protein in activation of antioxidant response by oxidants. Mol Pharmacol. 2007;72:1074-1081.
46. Yang H, Magilnick N, Lee C, et al. Lu1* Nrf1 and Nrf2 regulate rat glutamate-cysteine ligase catalytic subunit transcription indirectly via NF--B and AP-1. Mol Cell Biol. 2005;25:5933-5946.
47. Cotto JJ, Kline M, Morimoto RI. Activation of heat shock factor 1 DNA binding precedes stress-induced serine phosphorylation. Evidence for a multistep pathway of regulation. J Biol Chem. 1996;271:3355-3358.
48. Cotto JJ, Morimoto RI. Stress-induced activation of the heat-shock response: cell and molecular biology of heat-shock factors. Biochem Soc Symp. 1999;64:105-118.
49. Morimoto RI, Kline MP, Bimston DN, et al. The heat-shock response: regulation and function of heat-shock proteins and molecular chaperones. Essays Biochem. 1997;32:17-29.
50. Rao CV, Simi B, Reddy BS. Inhibition by dietary curcumin of azoxymethane-induced ornithine decarboxylase, tyrosine protein kinase, arachidonic acid metabolism and aberrant crypt foci formation in the rat colon. Carcinogenesis. 1993;14:2219-2225. (Pubitemid 23335173)
51. Nakayama H, Chen X, Baines CP, et al. Ca2+- and mitochondrialdependent cardiomyocyte necrosis as a primary mediator of heart failure. J Clin Invest. 2007;117:2431-2444.
52. Tavi P, Hansson A, Zhang SJ, et al. Abnormal Ca(2+) release and catecholamine-induced arrhythmias in mitochondrial cardiomyopathy. Hum Mol Genet. 2005;14:1069-1076.
53. Sun YB, Lou F, Irving M. Calcium- and myosin-dependent changes in troponin structure during activation of heart muscle. J Physiol. 2009;587: 155-163.
54. Marston SB, de Tombe PP. Troponin phosphorylation and myofilament Ca2+-sensitivity in heart failure: increased or decreased? J Mol Cell Cardiol. 2008;45:603-607.
55. Davis JP, Tikunova SB. Ca(2+) exchange with troponin C and cardiac muscle dynamics. Cardiovasc Res. 2008;77:619-626.
56. Weaver AD, Bowker BC, Gerrard DE. Sarcomere length influences mucalpain- mediated proteolysis of bovine myofibrils. J Anim Sci. 2009;87: 2096-2103.
57. Van Eyk JE, Powers F, Law W, et al. Breakdown and release of myofilament proteins during ischemia and ischemia/reperfusion in rat hearts: identification of degradation products and effects on the pCa-force relation. Circ Res. 1998;82:261-271.
58. Sakamoto K, Urushidani T, Nagao T. Translocation of HSP27 to sarcomere induced by ischemic preconditioning in isolated rat hearts. Biochem Biophys Res Commun. 2000;269:137-142.
59. Eaton P, Awad WI, Miller JI, et al. Ischemic preconditioning: a potential role for constitutive low molecular weight stress protein translocation and phosphorylation? J Mol Cell Cardiol. 2000;32:961-971.
60. Lu XY, Chen L, Cai XL, et al. Overexpression of heat shock protein 27 protects against ischaemia/reperfusion-induced cardiac dysfunction via stabilization of troponin I and T. Cardiovasc Res. 2008;79:500-508.
61. Mounier N, Arrigo AP. Actin cytoskeleton and small heat shock proteins: how do they interact? Cell Stress Chaperones. 2002;7:167-176.
62. Molitoris BA, Leiser J, Wagner MC. Role of the actin cytoskeleton in ischemia-induced cell injury and repair. Pediatr Nephrol. 1997;11: 761-767.