메뉴 건너뛰기




Volumn 44, Issue 11, 2011, Pages 713-718

Both sitagliptin analogue & pioglitazone preserve the β-cell proportion in the islets with different mechanism in non-obese and obese diabetic mice

Author keywords

Akita mice; Db db mice; Pioglitazone; Sitagliptin analogue; Type 2 diabetes

Indexed keywords

ANIMALIA; MUS;

EID: 84863230187     PISSN: 19766696     EISSN: 1976670X     Source Type: Journal    
DOI: 10.5483/BMBRep.2011.44.11.713     Document Type: Article
Times cited : (18)

References (36)
  • 2
    • 0019810028 scopus 로고
    • Physiologic evaluation of factors controlling glucose tolerance in man: measurement of insulin sensitivity and beta-cell glucose sensitivity from the response to intravenous glucose
    • Bergman, R. N., Phillips, L. S. and Cobelli, C. (1981) Physiologic evaluation of factors controlling glucose tolerance in man: measurement of insulin sensitivity and beta-cell glucose sensitivity from the response to intravenous glucose. J. Clin. Invest. 68, 1456-1467.
    • (1981) J. Clin. Invest. , vol.68 , pp. 1456-1467
    • Bergman, R.N.1    Phillips, L.S.2    Cobelli, C.3
  • 3
    • 0037219411 scopus 로고    scopus 로고
    • Beta-cell deficit and increased beta- cell apoptosis in humans with type 2 diabetes
    • Butler, A. E., Janson, J., Bonner-Weir, S., Ritzel, R., Rizza, R. A. and Butler, P. C. (2003) Beta-cell deficit and increased beta- cell apoptosis in humans with type 2 diabetes. Diabetes 52, 102-110.
    • (2003) Diabetes , vol.52 , pp. 102-110
    • Butler, A.E.1    Janson, J.2    Bonner-Weir, S.3    Ritzel, R.4    Rizza, R.A.5    Butler, P.C.6
  • 4
    • 0032511583 scopus 로고    scopus 로고
    • Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)
    • UK., Prospective Diabetes Study (UKPDS), Group
    • UK Prospective Diabetes Study (UKPDS) Group. (1998) Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 352, 837-853.
    • (1998) Lancet , vol.352 , pp. 837-853
  • 5
    • 0033867213 scopus 로고    scopus 로고
    • Linear correlation between beta-cell mass and body weight throughout the lifespan in Lewis rats: role of beta-cell hyperplasia and hypertrophy
    • Montanya, E., Nacher, V., Biarns, M. and Soler, J. (2000) Linear correlation between beta-cell mass and body weight throughout the lifespan in Lewis rats: role of beta-cell hyperplasia and hypertrophy. Diabetes 49, 1341-1346.
    • (2000) Diabetes , vol.49 , pp. 1341-1346
    • Montanya, E.1    Nacher, V.2    Biarns, M.3    Soler, J.4
  • 6
    • 0037342614 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV inhibitor treatment stimulates beta-cell survival and islet neogenesis in streptozotocin-induced diabetic rats
    • Pospisilik, J. A., Martin, J., Doty, T., Ehses, J. A., Pamir, N., Lynn, F. C., Piteau, S., Demuth, H., McIntosh, C. H. and Pederson, R. A. (2003) Dipeptidyl peptidase IV inhibitor treatment stimulates beta-cell survival and islet neogenesis in streptozotocin-induced diabetic rats. Diabetes 52, 741-750.
    • (2003) Diabetes , vol.52 , pp. 741-750
    • Pospisilik, J.A.1    Martin, J.2    Doty, T.3    Ehses, J.A.4    Pamir, N.5    Lynn, F.C.6    Piteau, S.7    Demuth, H.8    McIntosh, C.H.9    Pederson, R.A.10
  • 7
    • 33748331194 scopus 로고    scopus 로고
    • Chronic inhibition of dipeptidyl peptidase-4 with a sitagliptin analog preserves pancreatic beta-cell mass and function in a rodent model of type 2 diabetes
    • Mu, J., Woods, J., Zhou, Y., Roy, R. S., Li, Z., Zycband, E., Feng, Y., Zhu, L., Li, C., Howard, A. D., Moller, D. E., Thornberry, N. A. and Zhang, B. (2006) Chronic inhibition of dipeptidyl peptidase-4 with a sitagliptin analog preserves pancreatic beta-cell mass and function in a rodent model of type 2 diabetes. Diabetes 55, 1695-1704.
    • (2006) Diabetes , vol.55 , pp. 1695-1704
    • Mu, J.1    Woods, J.2    Zhou, Y.3    Roy, R.S.4    Li, Z.5    Zycband, E.6    Feng, Y.7    Zhu, L.8    Li, C.9    Howard, A.D.10    Moller, D.E.11    Thornberry, N.A.12    Zhang, B.13
  • 8
    • 0037312818 scopus 로고    scopus 로고
    • Glucagon-like peptides: regulators of cell proliferation, differentiation, and apoptosis
    • Drucker, D. J. (2003) Glucagon-like peptides: regulators of cell proliferation, differentiation, and apoptosis. Mol. Endocrinol. 17, 161-171.
    • (2003) Mol. Endocrinol. , vol.17 , pp. 161-171
    • Drucker, D.J.1
  • 10
    • 33845489598 scopus 로고    scopus 로고
    • Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy in patients with type 2 diabetes mellitus
    • Raz, I., Hanefeld, M., Xu, L., Caria, C., Williams-Herman, D. and Khatami, H. (2006) Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy in patients with type 2 diabetes mellitus. Diabetologia 49, 2564-2571.
    • (2006) Diabetologia , vol.49 , pp. 2564-2571
    • Raz, I.1    Hanefeld, M.2    Xu, L.3    Caria, C.4    Williams-Herman, D.5    Khatami, H.6
  • 11
    • 0033613181 scopus 로고    scopus 로고
    • Troglitazone prevents mitochondrial alterations, beta cell destruction, and diabetes in obese prediabetic rats
    • Higa, M., Zhou, Y. T., Ravazzola, M., Baetens, D., Orci, L. and Unger, R. H. (1999) Troglitazone prevents mitochondrial alterations, beta cell destruction, and diabetes in obese prediabetic rats. Proc. Natl. Acad. Sci. U.S.A. 96, 11513-11518.
    • (1999) Proc. Natl. Acad. Sci. U.S.A. , vol.96 , pp. 11513-11518
    • Higa, M.1    Zhou, Y.T.2    Ravazzola, M.3    Baetens, D.4    Orci, L.5    Unger, R.H.6
  • 12
    • 0035042679 scopus 로고    scopus 로고
    • Betacell mass dynamics in Zucker diabetic fatty rats. Rosiglitazone prevents the rise in net cell death
    • Finegood, D. T., McArthur, M. D., Kojwang, D., Thomas, M. J., Topp, B. G., Leonard, T. and Buckingham, R. E. (2001) Betacell mass dynamics in Zucker diabetic fatty rats. Rosiglitazone prevents the rise in net cell death. Diabetes 50, 1021-1029.
    • (2001) Diabetes , vol.50 , pp. 1021-1029
    • Finegood, D.T.1    McArthur, M.D.2    Kojwang, D.3    Thomas, M.J.4    Topp, B.G.5    Leonard, T.6    Buckingham, R.E.7
  • 13
    • 33947149143 scopus 로고    scopus 로고
    • Beta-cell preservation with thiazolidinediones
    • Campbell, I. W. and Mariz, S. (2007) Beta-cell preservation with thiazolidinediones. Diabetes Res. Clin. Pract. 76, 163-176.
    • (2007) Diabetes Res. Clin. Pract. , vol.76 , pp. 163-176
    • Campbell, I.W.1    Mariz, S.2
  • 15
    • 0030907296 scopus 로고    scopus 로고
    • A novel locus, Mody4, distal to D7Mit189 on chromosome 7 determines early-onset NIDDM in nonobese C57BL/6 (Akita) mutant mice
    • Yoshioka, M., Kayo, T., Ikeda, T. and Koizumi, A. (1997) A novel locus, Mody4, distal to D7Mit189 on chromosome 7 determines early-onset NIDDM in nonobese C57BL/6 (Akita) mutant mice. Diabetes 46, 887-894.
    • (1997) Diabetes , vol.46 , pp. 887-894
    • Yoshioka, M.1    Kayo, T.2    Ikeda, T.3    Koizumi, A.4
  • 16
    • 33846006173 scopus 로고    scopus 로고
    • The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes
    • Drucker, D. J. and Nauck, M. A. (2006) The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Lancet 368, 1696-1705.
    • (2006) Lancet , vol.368 , pp. 1696-1705
    • Drucker, D.J.1    Nauck, M.A.2
  • 17
    • 67650245531 scopus 로고    scopus 로고
    • Beneficial endocrine but adverse exocrine effects of sitagliptin in the human islet amyloid polypeptide transgenic rat model of type 2 diabetes: interactions with metformin
    • Matveyenko, A. V., Dry, S., Cox, H. I., Moshtaghian, A., Gurlo, T., Galasso, R., Butler, A. E. and Butler, P. C. (2009) Beneficial endocrine but adverse exocrine effects of sitagliptin in the human islet amyloid polypeptide transgenic rat model of type 2 diabetes: interactions with metformin. Diabetes 58, 1604-1615.
    • (2009) Diabetes , vol.58 , pp. 1604-1615
    • Matveyenko, A.V.1    Dry, S.2    Cox, H.I.3    Moshtaghian, A.4    Gurlo, T.5    Galasso, R.6    Butler, A.E.7    Butler, P.C.8
  • 19
    • 19244365650 scopus 로고    scopus 로고
    • Thiazolidinediones
    • Yki-Jrvinen, H. (2004) Thiazolidinediones. N. Engl. J. Med. 351, 1106-1118.
    • (2004) N. Engl. J. Med , vol.351 , pp. 1106-1118
    • Yki-Jrvinen, H.1
  • 20
    • 0037341238 scopus 로고    scopus 로고
    • Glucose toxicity in beta-cells: type 2 diabetes, good radicals gone bad, and the glutathione connection
    • Robertson, R. P., Harmon, J., Tran, P. O., Tanaka, Y. and Takahashi, H. (2003) Glucose toxicity in beta-cells: type 2 diabetes, good radicals gone bad, and the glutathione connection. Diabetes 52, 581-587.
    • (2003) Diabetes , vol.52 , pp. 581-587
    • Robertson, R.P.1    Harmon, J.2    Tran, P.O.3    Tanaka, Y.4    Takahashi, H.5
  • 21
    • 45449118936 scopus 로고    scopus 로고
    • Pioglitazone attenuates fatty acid-induced oxidative stress and apoptosis in pancreatic beta-cells
    • Saitoh, Y., Chun-ping, C., Noma, K., Ueno, H., Mizuta, M. and Nakazato, M. (2008) Pioglitazone attenuates fatty acid-induced oxidative stress and apoptosis in pancreatic beta-cells. Diabetes Obes. Metab. 10, 564-573.
    • (2008) Diabetes Obes. Metab. , vol.10 , pp. 564-573
    • Saitoh, Y.1    Chun-ping, C.2    Noma, K.3    Ueno, H.4    Mizuta, M.5    Nakazato, M.6
  • 22
    • 0037312881 scopus 로고    scopus 로고
    • Dominant negative pathogenesis by mutant proinsulin in the Akita diabetic mouse
    • Izumi, T., Yokota-Hashimoto, H., Zhao, S., Wang, J., Halban, P. A. and Takeuchi, T. (2003) Dominant negative pathogenesis by mutant proinsulin in the Akita diabetic mouse. Diabetes 52, 409-416.
    • (2003) Diabetes , vol.52 , pp. 409-416
    • Izumi, T.1    Yokota-Hashimoto, H.2    Zhao, S.3    Wang, J.4    Halban, P.A.5    Takeuchi, T.6
  • 23
    • 0036175128 scopus 로고    scopus 로고
    • Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes
    • Oyadomari, S., Koizumi, A., Takeda, K., Gotoh, T., Akira, S., Araki, E. and Mori, M. (2002) Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes. J. Clin. Invest. 109, 525-532.
    • (2002) J. Clin. Invest. , vol.109 , pp. 525-532
    • Oyadomari, S.1    Koizumi, A.2    Takeda, K.3    Gotoh, T.4    Akira, S.5    Araki, E.6    Mori, M.7
  • 24
    • 0036320896 scopus 로고    scopus 로고
    • Phagocytosis of apoptotic cells by macrophages from NOD mice is reduced
    • O'Brien, B. A., Huang, Y., Geng, X., Dutz, J. P. and Finegood, D. T. (2002) Phagocytosis of apoptotic cells by macrophages from NOD mice is reduced. Diabetes 51, 2481-2488.
    • (2002) Diabetes , vol.51 , pp. 2481-2488
    • O'Brien, B.A.1    Huang, Y.2    Geng, X.3    Dutz, J.P.4    Finegood, D.T.5
  • 25
    • 0033513455 scopus 로고    scopus 로고
    • Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats
    • Xu, G., Stoffers, D. A., Habener, J. F. and Bonner-Weir, S. (1999) Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats. Diabetes 48, 2270-2276.
    • (1999) Diabetes , vol.48 , pp. 2270-2276
    • Xu, G.1    Stoffers, D.A.2    Habener, J.F.3    Bonner-Weir, S.4
  • 27
    • 20444491588 scopus 로고    scopus 로고
    • Glucose-dependent insulinotropic polypeptide (GIP) stimulation of pancreatic beta-cell survival is dependent upon phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signaling, inactivation of the forkhead transcription factor Foxo1, and down-regulation of bax expression
    • Kim, S., Winter, K., Nian, C., Tsuneoka, M., Koda, Y. and McIntosh, C. H. (2005) Glucose-dependent insulinotropic polypeptide (GIP) stimulation of pancreatic beta-cell survival is dependent upon phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signaling, inactivation of the forkhead transcription factor Foxo1, and down-regulation of bax expression. J. Biol. Chem. 280, 22297-22307.
    • (2005) J. Biol. Chem. , vol.280 , pp. 22297-22307
    • Kim, S.1    Winter, K.2    Nian, C.3    Tsuneoka, M.4    Koda, Y.5    McIntosh, C.H.6
  • 28
    • 40749157994 scopus 로고    scopus 로고
    • Glucose-dependent insulinotropic polypeptide-mediated up-regulation of beta-cell antiapoptotic Bcl-2 gene expression is coordinated by cyclic AMP (cAMP) response element binding protein (CREB) and cAMP-responsive CREB coactivator Mol
    • Kim, S., Nian, C., Widenmaier, S. and McIntosh, C. H. (2008) Glucose-dependent insulinotropic polypeptide-mediated up-regulation of beta-cell antiapoptotic Bcl-2 gene expression is coordinated by cyclic AMP (cAMP) response element binding protein (CREB) and cAMP-responsive CREB coactivator Mol. Cell. Biol. 28, 1644-1656.
    • (2008) Cell. Biol. , vol.28 , pp. 1644-1656
    • Kim, S.1    Nian, C.2    Widenmaier, S.3    McIntosh, C.H.4
  • 29
    • 33847617011 scopus 로고    scopus 로고
    • Mechanisms of action of glucagon-like peptide 1 in the pancreas
    • Doyle, M. E. and Egan, J. M. (2007) Mechanisms of action of glucagon-like peptide 1 in the pancreas. Pharmacol. Ther. 113, 546-593.
    • (2007) Pharmacol. Ther. , vol.113 , pp. 546-593
    • Doyle, M.E.1    Egan, J.M.2
  • 30
    • 33645239679 scopus 로고    scopus 로고
    • Stimulation of pancreatic beta-cell replication by incretins involves transcriptional induction of cyclin D1 via multiple signalling pathways
    • Friedrichsen, B. N., Neubauer, N., Lee, Y. C., Gram, V. K., Blume, N., Petersen, J. S., Nielsen, J. H. and Mldrup, A. (2006) Stimulation of pancreatic beta-cell replication by incretins involves transcriptional induction of cyclin D1 via multiple signalling pathways. J. Endocrinol. 188, 481-492.
    • (2006) J. Endocrinol. , vol.188 , pp. 481-492
    • Friedrichsen, B.N.1    Neubauer, N.2    Lee, Y.C.3    Gram, V.K.4    Blume, N.5    Petersen, J.S.6    Nielsen, J.H.7    Mldrup, A.8
  • 32
    • 12344323484 scopus 로고    scopus 로고
    • Type 2 diabetes-a matter of beta-cell life and death?
    • Rhodes, C. J. (2005) Type 2 diabetes-a matter of beta-cell life and death? Science 307, 380-384.
    • (2005) Science , vol.307 , pp. 380-384
    • Rhodes, C.J.1
  • 33
    • 0024508097 scopus 로고
    • Compensatory growth of pancreatic beta-cells in adult rats after short-term glucose infusion
    • Bonner-Weir, S., Deery, D., Leahy, J. L. and Weir, G. C. (1989) Compensatory growth of pancreatic beta-cells in adult rats after short-term glucose infusion. Diabetes 38, 49-53.
    • (1989) Diabetes , vol.38 , pp. 49-53
    • Bonner-Weir, S.1    Deery, D.2    Leahy, J.L.3    Weir, G.C.4
  • 34
    • 0026573783 scopus 로고
    • Adaptation of islets of Langerhans to pregnancy: increased islet cell proliferation and insulin secretion correlates with the onset of placental lactogen secretion
    • Parsons, J. A., Brelje, T. C. and Sorenson, R. L. (1992) Adaptation of islets of Langerhans to pregnancy: increased islet cell proliferation and insulin secretion correlates with the onset of placental lactogen secretion. Endocrinology 130, 1459-1466.
    • (1992) Endocrinology , vol.130 , pp. 1459-1466
    • Parsons, J.A.1    Brelje, T.C.2    Sorenson, R.L.3
  • 35
    • 13844262626 scopus 로고    scopus 로고
    • Structural and functional analysis of pancreatic islets preserved by pioglitazone in db/db mice
    • Kawasaki, F., Matsuda, M., Kanda, Y., Inoue, H. and Kaku, K. (2005) Structural and functional analysis of pancreatic islets preserved by pioglitazone in db/db mice. Am. J. Physiol. Endocrinol. Metab. 288, E510-518.
    • (2005) Am. J. Physiol. Endocrinol. Metab. , vol.288
    • Kawasaki, F.1    Matsuda, M.2    Kanda, Y.3    Inoue, H.4    Kaku, K.5
  • 36
    • 38449111196 scopus 로고    scopus 로고
    • Differential antidiabetic efficacy of incretin agonists versus DPP-4 inhibition in high fat fed mice
    • Lamont, B. J. and Drucker, D. J. (2008) Differential antidiabetic efficacy of incretin agonists versus DPP-4 inhibition in high fat fed mice. Diabetes 57, 190-198.
    • (2008) Diabetes , vol.57 , pp. 190-198
    • Lamont, B.J.1    Drucker, D.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.