Synthesis and structure-activity relationship of ethacrynic acid analogues on glutathione-s-transferase P1-1 activity inhibition

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 12, 2005, Pages 4056-4062

  Zhao, Guisen ^a   Yu, Tao ^a   Wang, Rui ^b   Wang, Xiaobing ^a   Jing, Yongkui ^c  

^a SHANDONG UNIVERSITY   (China)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Ehtacrynic acid; Glutathione s transferase; Structure activity relationship

Indexed keywords

2 [2 CHLORO 4 (2 METHYLENE 1 OXOBUTYL)PHENOXY]PROPIONIC ACID; 2 [2 CHLORO 4 (2 METHYLENE 1 OXOPROPYL)PHENOXY]PROPIONIC ACID; 2 [2 FLUORO 4 (2 METHYLENE 1 OXOBUTYL)PHENOXY]PROPIONIC ACID; 2 [2 FLUORO 4 (2 METHYLENE 1 OXOPROPYL)PHENOXY]PROPIONIC ACID; 2 [2 METHYL 4 (2 METHYLENE 1 OXOBUTYL)PHENOXY]PROPIONIC ACID; 2 [2 METHYL 4 (2 METHYLENE 1 OXOPROPYL)PHENOXY]PROPIONIC ACID; 2 [2,3 DIMETHYL 4 (2 METHYLENE 1 OXOBUTYL)PHENOXY]PROPIONIC ACID; 2 [2,3 DIMETHYL 4 (2 METHYLENE 1 OXOPROPYL)PHENOXY]PROPIONIC ACID; [2 CHLORO 4 (2 METHYLENE 1 OXOBUTYL)PHENOXY]ACETIC ACID; [2 CHLORO 4 (2 METHYLENE 1 OXOPROPYL)PHENOXY]ACETIC ACID; [2 FLUORO 4 (2 METHYLENE 1 OXOBUTYL)PHENOXY]ACETIC ACID; [2 FLUORO 4 (2 METHYLENE 1 OXOPROPYL)PHENOXY]ACETIC ACID; [2 METHYL 4 (2 METHYLENE 1 OXOPROPYL)PHENOXY]ACETIC ACID; [2,3 DIMETHYL 4 (2 METHYLENE 1 OXOPROPYL)PHENOXY]ACETIC ACID; [3 BROMO 4 (2 METHYLENE 1 OXOPROPYL)PHENOXY]ACETIC ACID; ETACRYNIC ACID; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE P1 1; UNCLASSIFIED DRUG;

ARTICLE; CANCER; CHEMICAL REACTION KINETICS; DRUG DESIGN; DRUG MECHANISM; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; INHIBITION KINETICS; LEUKEMIA CELL; STRUCTURE ACTIVITY RELATION; SUBSTITUTION LINE;

ANIMALS; CELL EXTRACTS; CELL LINE, TUMOR; DRUG DESIGN; ETHACRYNIC ACID; GLUTATHIONE S-TRANSFERASE PI; GLUTATHIONE TRANSFERASE; HALOGENS; HL-60 CELLS; HUMANS; ISOENZYMES; MICE; MICE, INBRED STRAINS; STRUCTURE-ACTIVITY RELATIONSHIP; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 19444377856     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.03.046     Document Type: Article

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