Reactive oxygen species signaling facilitates FOXO-3a/FBXO-dependent vascular BK channel β 1 subunit degradation in diabetic mice

Diabetes

Volumn 61, Issue 7, 2012, Pages 1860-1868

  Lu, Tong ^a   Chai, Qiang ^a,b   Yu, Ling ^a,c   D'Uscio, Livius V ^a   Katusic, Zvonimir S ^a   He, Tongrong ^a   Lee, Hon Chi ^a  

^a MAYO CLINIC   (United States)

^b SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG FIRST MEDICAL UNIVERSITY   (China)

^c FUJIAN PROVINCIAL HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

[2 METHYL 4 [4 METHYL 2 (4 TRIFLUOROMETHYLPHENYL) 5 THIAZOLYLMETHYLTHIO]PHENOXY]ACETIC ACID; ATROGIN 1; BK CHANNEL BETA 1; GLUCOSE; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL BETA SUBUNIT; NITRIC OXIDE; PROTEIN KINASE C BETA; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; RUBOXISTAURIN; TRANSCRIPTION FACTOR FKHRL1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DIABETES MELLITUS; DIABETIC ANGIOPATHY; DOWN REGULATION; ENZYME PHOSPHORYLATION; HEART FUNCTION; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER;

ANIMALS; ARTERIES; CELLS, CULTURED; DIABETES MELLITUS, EXPERIMENTAL; ENZYME INHIBITORS; F-BOX PROTEINS; FORKHEAD TRANSCRIPTION FACTORS; GLUCOSE; INDOLES; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL BETA SUBUNITS; MALEIMIDES; MICE; MICROSCOPY, VIDEO; MUSCLE PROTEINS; MUSCLE, SMOOTH, VASCULAR; NADPH OXIDASE; PATCH-CLAMP TECHNIQUES; PROTEIN KINASE C; PROTEOLYSIS; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; SKP CULLIN F-BOX PROTEIN LIGASES; THIAZOLES; VASODILATION;

EID: 84863217619     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db11-1658     Document Type: Article

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