Activation of vascular BK channels by docosahexaenoic acid is dependent on cytochrome P450 epoxygenase activity

Cardiovascular Research

Volumn 90, Issue 2, 2011, Pages 344-352

  Wang, Ru Xing ^a,b   Chai, Qiang ^a,c   Lu, Tong ^a   Lee, Hon Chi ^a  

^a MAYO CLINIC   (United States)

^b NANJING MEDICAL UNIVERSITY   (China)

^c SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG FIRST MEDICAL UNIVERSITY   (China)

Author keywords

16,17 Epoxydocosapentaenoic acid; BK channel; Coronary arterial smooth muscle cell; Cytochrome P450 epoxygenase; Docosahexaenoic acid

Indexed keywords

16,17 EPOXYDOCOSAPENTAENOIC ACID; CYTOCHROME P450; DOCOSAHEXAENOIC ACID; IBERIOTOXIN; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; PROADIFEN; UNCLASSIFIED DRUG; UNSATURATED FATTY ACID;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY; DOSE RESPONSE; ENZYME ACTIVITY; ENZYME INHIBITION; METABOLITE; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE FIBER; VASODILATATION; WHOLE CELL;

ANIMALS; CORONARY VESSELS; CYTOCHROME P-450 ENZYME SYSTEM; DOCOSAHEXAENOIC ACIDS; ENZYME INHIBITORS; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MUSCLE, SMOOTH, VASCULAR; PATCH-CLAMP TECHNIQUES; PEPTIDES; POTASSIUM; PROADIFEN; RATS; RATS, SPRAGUE-DAWLEY; VASODILATION;

EID: 79955364412     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvq411     Document Type: Article

References (29)

1. Breslow JL n-3 fatty acids and cardiovascular disease. Am J Clin Nutr 2006;83: 1477S-1482S. (Pubitemid 44713088)
2. Lavie CJ, Milani RV, Mehra MR, Ventura HO. Omega-3 polyunsaturated fatty acids and cardiovascular diseases. J Am Coll Cardiol 2009;54:585-594.
3. Kris-Etherton PM, Harris WS, Appel LJ. Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Circulation 2002;106:2747-2757. (Pubitemid 35364932)
4. Metcalf RG, James MJ, Gibson RA, Edwards JR, Stubberfield J, Stuklis R et al. Effects of fish-oil supplementation on myocardial fatty acids in humans. Am J Clin Nutr 2007;85: 1222-1228. (Pubitemid 46740462)
5. Mori TA, Burke V, Puddey IB, Watts GF, O'Neal DN, Best JD et al. Purified eicosa-pentaenoic and docosahexaenoic acids have differential effects on serum lipids and lipoproteins, LDL particle size, glucose, and insulin in mildly hyperlipidemic men. Am J Clin Nutr 2000;71:1085-1094. (Pubitemid 30230554)
6. Woodman RJ, Mori TA, Burke V, Puddey IB, Barden A, Watts GF et al. Effects of purified eicosapentaenoic acid and docosahexaenoic acid on platelet, fibrinolytic and vascular function in hypertensive type 2 diabetic patients. Atherosclerosis 2003; 166:85-93. (Pubitemid 35449604)
7. Mori TA, Bao DQ, Burke V, Puddey IB, Beilin LJ. Docosahexaenoic acid but not eicosapentaenoic acid lowers ambulatory blood pressure and heart rate in humans. Hypertension 1999;34:253-260. (Pubitemid 29409224)
8. Schmitz G, Ecker J. The opposing effects of n-3 and n-6 fatty acids. Prog Lipid Res 2008;47:147-155.
9. Fer M, Dreano Y, Lucas D, Corcos L, Salaun JP, Berthou F, et al. Metabolism of eico-sapentaenoic and docosahexaenoic acids by recombinant human cytochromes P450. Arch Biochem Biophys 2008;471:116-125.
10. Spector AA. Arachidonic acid cytochrome P450 epoxygenase pathway. J Lipid Res 2009;50(Suppl):S52-S56.
11. Zhou W, Wang XL, Lamping KG, Lee HC. Inhibition of protein kinase Cβ protects against diabetes-induced impairment in arachidonic acid dilation of small coronary arteries. J Pharmacol Exp Ther 2006;319:199-207. (Pubitemid 44455124)
12. Lu T, Zhang DM, Wang XL, He T, Wang RX, Chai Q, et al. Regulation of coronary arterial BKchannels bycaveolae-mediated angiotensin II signaling in diabetes mellitus. Circ Res 2010;106:1164-1173.
13. Nelson MT, Cheng H, Rubart M, Santana LF, Bonev AD, Knot HJ, et al. Relaxation of arterial smooth muscle by calcium sparks. Science 1995;270:633-637.
14. Horn R, Marty A. Muscarinic activation of ionic currents measured by a new whole-cell recording method. J Gen Physiol 1988;92:145-159.
15. London B, Albert C, Anderson ME, Giles WR, Van Wagoner DR, Balk E et al. Omega-3 fatty acids and cardiac arrhythmias: prior studies and recommendations for future research: a report from the National Heart, Lung, and Blood Institute and Office Of Dietary Supplements Omega-3 Fatty Acids and their Role in Cardiac Arrhythmogenesis Workshop. Circulation 2007;116:e320-e335. (Pubitemid 47360222)
16. Xiao YF, Sigg DC, Leaf A. The antiarrhythmic effect of n-3 polyunsaturated fatty acids: modulation ofcardiac ion channels as a potential mechanism. J Membr Biol 2005;206: 141-154. (Pubitemid 43199147)
17. Eichhorn B, Dobrev D. Vascular large conductance calcium-activated potassium chan-nels: functional role and therapeutic potential. Naunyn Schmiedebergs Arch Pharmacol 2007;376:145-155. (Pubitemid 350029414)
18. Zhou W, Lu T, Spector AA, Lee HC. Inhibition of PGI2 signaling by miconazole in vas-cular smooth muscle cells. Prostaglandins Other Lipid Mediat 2006;80:28-34. (Pubitemid 44038604)
19. Gauthier KM, Deeter C, Krishna UM, Reddy YK, Bondlela M, Falck JR et al. 14, 15-Epoxyeicosa-5(Z)-enoic acid: a selective epoxyeicosatrienoic acid antagonist that inhibits endothelium-dependent hyperpolarization and relaxation in coronary arteries. Circ Res 2002;90:1028-1036. (Pubitemid 34633870)
20. Harper CR, Edwards MJ, DeFilippis AP, Jacobson TA. Flaxseed oil increases the plasma concentrations of cardioprotective (n-3) fatty acids in humans. J Nutr 2006; 136:83-87. (Pubitemid 43156489)
21. Campbell WB, Gebremedhin D, Pratt PF, Harder DR. Identification of epoxyeicosa-trienoic acids as endothelium-derived hyperpolarizing factors. Circ Res 1996;78: 415-423. (Pubitemid 26072547)
22. + channels in isolated rat coronary arterial myocytes. J Physiol 2001;534:651-667. (Pubitemid 32700865)
23. Brash AR. Arachidonic acid as a bioactive molecule. J Clin Invest 2001;107:1339-1345. (Pubitemid 32522025)
24. Russo GL. Dietary n-6 and n-3 polyunsaturatedfattyacids: from biochemistry to clini-cal implications in cardiovascular prevention. Biochem Pharmacol 2009;77:937-946.
25. Yang W, Tuniki VR, Anjaiah S, Falck JR, Hillard CJ, Campbell WB. Characterization of epoxyeicosatrienoic acid binding site in U937 membranes using a novel radiolabeled agonist, 20-I-14, 15-epoxyeicosa-8(Z)-enoic acid. J Pharmacol Exp Ther 2008;324: 1019-1027. (Pubitemid 351397827)
26. VanRollins M. Epoxygenase metabolites of docosahexaenoic and eicosapentaenoic acids inhibit platelet aggregation at concentrations below those affecting thrombox-ane synthesis. J Pharmacol Exp Ther 1995;274:798-804.
27. Fisslthaler B, Hinsch N, Chataigneau T, Popp R, Kiss L, Busse R et al. Nifedipine increases cytochrome P4502C expression and endothelium-derived hyperpolarizing factor-mediated responses in coronary arteries. Hypertension 2000;36:270-275. (Pubitemid 30626999)
28. + channels: a functional unit for regulating arterial tone. Acta Physiol Scand 1998;164:577-587. (Pubitemid 29015676)
29. Hercule HC, Salanova B, Essin K, Honeck H, Falck JR, Sausbier M et al. The vasodilator 17, 18-epoxyeicosatetraenoic acid targets the pore-forming BK α channel subunit in rodents. Exp Physiol 2007;92:1067-1076. (Pubitemid 47568840)