1-Methyl-4-phenylpyridinium induces synaptic dysfunction through a pathway involving caspase and PKCδ enzymatic activities

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 7, 2007, Pages 2437-2441

  Serulle, Yafell ^a,b   Morfini, Gerardo ^b,c   Pigino, Gustavo ^b,c   Moreira, Jorge E ^b,d   Sugimori, Mutsuyuki ^a,b   Brady, Scott T ^b,c   Llinás, Rodolfo R ^a,b  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MARINE BIOLOGICAL LABORATORY   (United States)

^c UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^d UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

MPP+; Parkinson's disease; Presynaptic terminal; Synaptic potentials; Voltage clamp

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; 1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; CASPASE; PROTEIN KINASE C DELTA;

ACTION POTENTIAL; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM CURRENT; DOPAMINERGIC NERVE CELL; ENZYME ACTIVITY; NERVE ENDING; NIGRONEOSTRIATAL SYSTEM; NONHUMAN; PARKINSON DISEASE; PATHOGENESIS; PRIORITY JOURNAL; SQUID; SYNAPTIC TRANSMISSION; VOLTAGE CLAMP;

1-METHYL-4-PHENYLPYRIDINIUM; ANIMALS; CASPASE 3; CHROMOSOME PAIRING; DECAPODIFORMES; DISEASE MODELS, ANIMAL; NEURONS; PARKINSON DISEASE; PROTEIN KINASE C-DELTA; SIGNAL TRANSDUCTION; SYNAPSES; SYNAPTIC VESICLES;

CEPHALOPODA; MAMMALIA; PARKINSONIA;

EID: 33847784020     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0611227104     Document Type: Article

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