Aberrant cyclization affords a C-6 modified cyclic adenosine 5′-diphosphoribose analogue with biological activity in Jurkat T cells

Journal of Medicinal Chemistry

Volumn 55, Issue 4, 2012, Pages 1478-1489

  Moreau, Christelle ^a   Kirchberger, Tanja ^b   Zhang, Bo ^a   Thomas, Mark P ^a   Weber, Karin ^b   Guse, Andreas H ^b   Potter, Barry V L ^a  

^a University of Bath   (United Kingdom)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

6 N METHYL NICOTINAMIDE ADENOSINE 5' DINUCLEOTIDE; 6 THIO CYCLIC INOSINE 5' DIPHOSPHORIBOSE; ADENOSINE 5' DIPHOSPHORIBOSE; CALCIUM ION; NICOTINAMIDE 6 MERCAPTOPURINE 5 DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM TRANSPORT; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; T LYMPHOCYTE;

ADP-RIBOSYL CYCLASE; ANIMALS; APLYSIA; CALCIUM; CYCLIC ADP-RIBOSE; CYCLIZATION; HUMANS; HYDROGEN-ION CONCENTRATION; JURKAT CELLS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PERMEABILITY; STRUCTURE-ACTIVITY RELATIONSHIP; T-LYMPHOCYTES; THIOINOSINE;

EID: 84863166240     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm201127y     Document Type: Article

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