Synthesis of stable and cell-type selective analogues of cyclic ADP-ribose, a Ca2+-mobilizing second messenger. Structure-activity relationship of the N1-ribose moiety

Journal of the American Chemical Society

Volumn 127, Issue 24, 2005, Pages 8846-8855

  Kudoh, Takashi ^a   Fukuoka, Masayoshi ^a   Ichikawa, Satoshi ^a   Murayama, Takashi ^b   Ogawa, Yasuo ^b   Hashii, Minako ^c   Higashida, Haruhiro ^c   Kunerth, Svenja ^d   Weber, Karin ^d   Guse, Andreas H ^d   Potter, Barry V L ^e   Matsuda, Akira ^a   Shuto, Satoshi ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c KANAZAWA UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCE   (Japan)

^d UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^e University of Bath   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLIC ACIDS; CELLS; CONDENSATION; CONFORMATIONS; MOLECULAR STRUCTURE; PROTEINS; REACTION KINETICS; SYNTHESIS (CHEMICAL);

ADP-CARBOCYLIC RIBOSE; INTRAMOLECULAR CONDENSATION REACTIONS; NEURONAL CELLS; STERIC REPULSION;

SUGARS;

CALCIUM ION; CYCLIC ADENOSINE DIPHOSPHATE CARBOCYCLIC RIBOSE; CYCLIC ADENOSINE DIPHOSPHATE RIBOSE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CALCIUM MOBILIZATION; CARBON NUCLEAR MAGNETIC RESONANCE; CELL TYPE; CHEMICAL REACTION; CHEMICAL STRUCTURE; CHIRALITY; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MOUSE; NERVE CELL; NONHUMAN; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; SEA URCHIN; SECOND MESSENGER; STRUCTURE ANALYSIS; SYNTHESIS;

ANIMALS; BIOMIMETIC MATERIALS; CALCIUM SIGNALING; CYCLIC ADP-RIBOSE; HUMANS; MOLECULAR CONFORMATION; NEURONS; OVUM; SEA URCHINS; STRUCTURE-ACTIVITY RELATIONSHIP; T-LYMPHOCYTES;

EID: 20944431987     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja050732x     Document Type: Article

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