Convergent Synthesis and Unexpected Ca2+-Mobilizing Activity of 8-Substituted Analogues of Cyclic ADP-Carbocyclic-Ribose, a Stable Mimic of the Ca2+-Mobilizing Second Messenger Cyclic ADP-Ribose

Journal of Medicinal Chemistry

Volumn 46, Issue 22, 2003, Pages 4741-4749

  Shuto, Satoshi ^a   Fukuoka, Masayoshi ^a   Kudoh, Takashi ^a   Garnham, Clive ^b   Galione, Antony ^b   Potter, Barry V L ^c   Matsuda, Akira ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c University of Bath   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

8 AMINOCYCLIC ADENOSINE DIPHOSPHATE CARBOCYCLIC RIBOSE; 8 AZIDOCYCLIC ADENOSINE DIPHOSPHATE CARBOCYCLIC RIBOSE; 8 CHLOROCYCLIC ADENOSINE DIPHOSPHATE CARBOCYCLIC RIBOSE; 8 PHENYLTHIOCYCLIC ADENOSINE DIPHOSPHATE CARBOCYCLIC RIBOSE; ADENOSINE DIPHOSPHATE RIBOSE; PYROPHOSPHORIC ACID DERIVATIVE; SILVER NITRATE; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM MOBILIZATION; CALCIUM SIGNALING; CALCIUM TRANSPORT; CHEMICAL STRUCTURE; DESENSITIZATION; DRUG EFFICACY; DRUG POTENCY; NONHUMAN; REACTION ANALYSIS; SEA URCHIN; SECOND MESSENGER; SYNTHESIS;

ANIMALS; CALCIUM; CALCIUM SIGNALING; CYCLIC ADP-RIBOSE; MOLECULAR MIMICRY; OVUM; SEA URCHINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0142092469     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm030227f     Document Type: Article

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