Airway activation of formyl peptide receptors inhibits Th1 and Th17 cell responses via inhibition of mediator release from immune and inflammatory cells and maturation of dendritic cells

Journal of Immunology

Volumn 188, Issue 4, 2012, Pages 1799-1808

  Tae, You Me ^a   Park, Hyun Taek ^a   Moon, Hyung Geun ^a   Kim, You Sun ^a   Jeon, Seong Gyu ^a   Roh, Tae Young ^a   Bae, Yoe Sik ^a   Gho, Yong Song ^b   Ryu, Sung Ho ^a   Kwon, Hyouk Soo ^a   Kim, Yoon Keun ^a  

^a Pohang University of Science and Technology (POSTECH)   (South Korea)

^b Sungkyunkwan University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

FORMYLPEPTIDE RECEPTOR; INTERLEUKIN 12; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; OVALBUMIN; PEPTIDE; TRYPTOPHANYLMETHIONYLVALYLMETHIONINE; UNCLASSIFIED DRUG;

AIRWAY SENSITIZATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTHMA; CELL MATURATION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DENDRITIC CELL; DRUG RECEPTOR BINDING; DRUG TARGETING; INFLAMMATORY CELL; LYMPH NODE; MOUSE; NONEOSINOPHILIC ASTHMA; NONHUMAN; PEPTIDE ANALYSIS; PNEUMONIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROVOCATION TEST; SENSITIZATION; TH1 CELL; TH17 CELL;

ANIMALS; ASTHMA; CELL DIFFERENTIATION; CELL MOVEMENT; CELL PROLIFERATION; DENDRITIC CELLS; DISEASE MODELS, ANIMAL; INTERLEUKIN-12; INTERLEUKIN-6; LUNG; LYMPH NODES; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; OLIGOPEPTIDES; OVALBUMIN; RECEPTORS, FORMYL PEPTIDE; TH1 CELLS; TH17 CELLS;

EID: 84863163693     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1102481     Document Type: Article

References (32)

1. Busse, W. W., and R. F. Lemanske, Jr. 2001. Asthma. N. Engl. J. Med. 344: 350-362. (Pubitemid 32107645)
2. Bochner, B. S., B. J. Undem, and L. M. Lichtenstein. 1994. Immunological aspects of allergic asthma. Annu. Rev. Immunol. 12: 295-335. (Pubitemid 24140417)
3. Cohn, L., J. A. Elias, and G. L. Chupp. 2004. Asthma: mechanisms of disease persistence and progression. Annu. Rev. Immunol. 22: 789-815. (Pubitemid 38680442)
4. Magnan, A. O., L. G. Mély, C. A. Camilla, M. M. Badier, F. A. Montero-Julian, C. M. Guillot, B. B. Casano, S. J. Prato, V. Fert, P. Bongrand, and D. Vervloet. 2000. Assessment of the Th1/Th2 paradigm in whole blood in atopy and asthma. Increased IFN-gamma-producing CD8(+) T cells in asthma. Am. J. Respir. Crit. Care Med. 161: 1790-1796. (Pubitemid 30418109)
5. Cho, S. H., L. A. Stanciu, S. T. Holgate, and S. L. Johnston. 2005. Increased interleukin-4, interleukin-5, and interferon-gamma in airway CD4+ and CD8+ T cells in atopic asthma. Am. J. Respir. Crit. Care Med. 171: 224-230.
6. Kim, Y. K., S. Y. Oh, S. G. Jeon, H. W. Park, S. Y. Lee, E. Y. Chun, B. Bang, H. S. Lee, M. H. Oh, Y. S. Kim, et al. 2007. Airway exposure levels of lipopolysaccharide determine type 1 versus type 2 experimental asthma. J. Immunol. 178: 5375-5382. (Pubitemid 46595324)
7. Migeotte, I., D. Communi, and M. Parmentier. 2006. Formyl peptide receptors: a promiscuous subfamily of G protein-coupled receptors controlling immune responses. Cytokine Growth Factor Rev. 17: 501-519. (Pubitemid 44793122)
8. Le, Y., P. M. Murphy, and J. M. Wang. 2002. Formyl-peptide receptors revisited. Trends Immunol. 23: 541-548. (Pubitemid 35223553)
9. Panaro, M. A., A. Acquafredda, M. Sisto, S. Lisi, A. B. Maffione, and V. Mitolo. 2006. Biological role of the N-formyl peptide receptors. Immunopharmacol. Immunotoxicol. 28: 103-127. (Pubitemid 43739112)
10. Gao, J. L., E. J. Lee, and P. M. Murphy. 1999. Impaired antibacterial host defense in mice lacking the N-formylpeptide receptor. J. Exp. Med. 189: 657-662.
11. Kim, S. D., Y. K. Kim, H. Y. Lee, Y. S. Kim, S. G. Jeon, S. H. Baek, D. K. Song, S. H. Ryu, and Y. S. Bae. 2010. The agonists of formyl peptide receptors prevent development of severe sepsis after microbial infection. J. Immunol. 185: 4302-4310.
12. Lee, M. S., S. A. Yoo, C. S. Cho, P. G. Suh, W. U. Kim, and S. H. Ryu. 2006. Serum amyloid A binding to formyl peptide receptor-like 1 induces synovial hyperplasia and angiogenesis. J. Immunol. 177: 5585-5594.
13. Dufton, N., R. Hannon, V. Brancaleone, J. Dalli, H. B. Patel, M. Gray, F. D'Acquisto, J. C. Buckingham, M. Perretti, and R. J. Flower. 2010. Antiinflammatory role of the murine formyl-peptide receptor 2: ligand-specific effects on leukocyte responses and experimental inflammation. J. Immunol. 184: 2611-2619.
14. Chiang, N., M. Arita, and C. N. Serhan. 2005. Anti-inflammatory circuitry: lipoxin, aspirin-triggered lipoxins and their receptor ALX. Prostaglandins Leukot. Essent. Fatty Acids 73: 163-177. (Pubitemid 41253473)
15. Chiang, N., C. N. Serhan, S. E. Dahlén, J. M. Drazen, D. W. Hay, G. E. Rovati, T. Shimizu, T. Yokomizo, and C. Brink. 2006. The lipoxin receptor ALX: potent ligand-specific and stereoselective actions in vivo. Pharmacol. Rev. 58: 463-487. (Pubitemid 44394909)
16. Planagumà, A., S. Kazani, G. Marigowda, O. Haworth, T. J. Mariani, E. Israel, E. R. Bleecker, D. Curran-Everett, S. C. Erzurum, W. J. Calhoun, et al. 2008. Airway lipoxin A4 generation and lipoxin A4 receptor expression are decreased in severe asthma. Am. J. Respir. Crit. Care Med. 178: 574-582.
17. Levy, B. D., G. T. De Sanctis, P. R. Devchand, E. Kim, K. Ackerman, B. A. Schmidt, W. Szczeklik, J. M. Drazen, and C. N. Serhan. 2002. Multipronged inhibition of airway hyper-responsiveness and inflammation by lipoxin A(4). Nat. Med. 8: 1018-1023. (Pubitemid 35033707)
18. Vachier, I., C. Bonnans, C. Chavis, M. Farce, P. Godard, J. Bousquet, and P. Chanez. 2005. Severe asthma is associated with a loss of LX4, an endogenous anti-inflammatory compound. J. Allergy Clin. Immunol. 115: 55-60. (Pubitemid 40075421)
19. Bae, Y. S., Y. Kim, Y. Kim, J. H. Kim, P. G. Suh, and S. H. Ryu. 1999. Trp-Lys- Tyr-Met-Val-D-Met is a chemoattractant for human phagocytic cells. J. Leukoc. Biol. 66: 915-922. (Pubitemid 30010515)
20. Bae, Y. S., S. A. Ju, J. Y. Kim, J. K. Seo, S. H. Baek, J. Y. Kwak, B. S. Kim, P. G. Suh, and S. H. Ryu. 1999. Trp-Lys-Tyr-Met-Val-D-Met stimulates superoxide generation and killing of Staphylococcus aureus via phospholipase D activation in human monocytes. J. Leukoc. Biol. 65: 241-248.
21. Kim, H., E. K. Noh, E. J. Lee, J. H. Baek, S. J. Shin, J. H. Park, K. H. Lee, and Y. J. Min. 2008. Enhanced bactericidal function by WKYMVm in patients with acute leukemia. Leuk. Res. 32: 717-725. (Pubitemid 351323932)
22. Dahlgren, C., T. Christophe, F. Boulay, P. N. Madianos, M. J. Rabiet, and A. Karlsson. 2000. The synthetic chemoattractant Trp-Lys-Tyr-Met-Val-DMet activates neutrophils preferentially through the lipoxin A(4) receptor. Blood 95: 1810-1818. (Pubitemid 30120847)
23. Zhu, Z., R. J. Homer, Z. Wang, Q. Chen, G. P. Geba, J. Wang, Y. Zhang, and J. A. Elias. 1999. Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J. Clin. Invest. 103: 779-788. (Pubitemid 29152623)
24. Kim, Y. S., S. J. Choi, Y. M. Tae, B. J. Lee, S. G. Jeon, S. Y. Oh, Y. S. Gho, Z. Zhu, and Y. K. Kim. 2010. Distinct roles of vascular endothelial growth factor receptor-1- and receptor-2-mediated signaling in T cell priming and Th17 polarization to lipopolysaccharide-containing allergens in the lung. J. Immunol. 185: 5648-5655.
25. Kim, Y. S., S. W. Hong, J. P. Choi, T. S. Shin, H. G. Moon, E. J. Choi, S. G. Jeon, S. Y. Oh, Y. S. Gho, Z. Zhu, and Y. K. Kim. 2009. Vascular endothelial growth factor is a key mediator in the development of T cell priming and its polarization to type 1 and type 17 T helper cells in the airways. J. Immunol. 183: 5113-5120.
26. Le, Y., W. Gong, B. Li, N. M. Dunlop, W. Shen, S. B. Su, R. D. Ye, and J. M. Wang. 1999. Utilization of two seven-transmembrane, G protein-coupled receptors, formyl peptide receptor-like 1 and formyl peptide receptor, by the synthetic hexapeptide WKYMVm for human phagocyte activation. J. Immunol. 163: 6777-6784.
27. Kang, H. K., H. Y. Lee, M. K. Kim, K. S. Park, Y. M. Park, J. Y. Kwak, and Y. S. Bae. 2005. The synthetic peptide Trp-Lys-Tyr-Met-Val-D-Met inhibits human monocyte-derived dendritic cell maturation via formyl peptide receptor and formyl peptide receptor-like 2. J. Immunol. 175: 685-692. (Pubitemid 41094948)
28. D'Acquisto, F., A. Merghani, E. Lecona, G. Rosignoli, K. Raza, C. D. Buckley, R. J. Flower, and M. Perretti. 2007. Annexin-1 modulates T-cell activation and differentiation. Blood 109: 1095-1102. (Pubitemid 46220656)
29. Sogawa, Y., T. Ohyama, H. Maeda, and K. Hirahara. 2011. Inhibition of neutrophil migration in mice by mouse formyl peptide receptors 1 and 2 dual agonist: indication of cross-desensitization in vivo. Immunology 132: 441-450.
30. Sogawa,Y., T. Ohyama, H.Maeda, and K. Hirahara. 2011. Formyl peptide receptor 1 and 2 dual agonist inhibits human neutrophil chemotaxis by the induction of chemoattractant receptor cross-desensitization. J. Pharmacol. Sci. 115: 63-68.
31. Serhan, C. N., S. Yacoubian, and R. Yang. 2008. Anti-inflammatory and proresolving lipid mediators. Annu. Rev. Pathol. 3: 279-312. (Pubitemid 351488283)
32. Lee, C. G., S. Y. Choi, S. H. Park, K. S. Park, S. H. Ryu, and Y. C. Sung. 2005. The synthetic peptide Trp-Lys-Tyr-Met-Val-D-Met as a novel adjuvant for DNA vaccine. Vaccine 23: 4703-4710.