Distinct roles of vascular endothelial growth factor receptor-1-and receptor-2-mediated signaling in T cell priming and Th17 polarization to lipopolysaccharide-containing allergens in the lung

Journal of Immunology

Volumn 185, Issue 9, 2010, Pages 5648-5655

  Kim, You Sun ^a   Choi, Seng Jin ^a   Tae, You Me ^a   Lee, Byung Jae ^b   Jeon, Seong Gyu ^a   Oh, Sun Young ^c   Gho, Yong Song ^a   Zhu, Zhou ^c   Kim, Yoon Keun ^a  

^a Pohang University of Science and Technology (POSTECH)   (South Korea)

^b Sungkyunkwan University   (South Korea)

^c JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; CYTOKINE; INTERLEUKIN 12P70; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; NEUTRALIZING ANTIBODY; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2; INTERLEUKIN 17;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MATURATION; CELL MIGRATION; CYTOKINE PRODUCTION; DENDRITIC CELL; IMMUNOLOGICAL TOLERANCE; IN VIVO STUDY; LYMPH NODE; MOUSE; NONHUMAN; POLARIZATION; PRIORITY JOURNAL; RECEPTOR BLOCKING; SENSITIZATION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TH1 CELL; TH17 CELL; UPREGULATION; ANIMAL; ASTHMA; BIOSYNTHESIS; C57BL MOUSE; CELL DIFFERENTIATION; CYTOLOGY; DISEASE MODEL; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOLOGY; LUNG; LYMPHOCYTE ACTIVATION; METABOLISM; T LYMPHOCYTE SUBPOPULATION;

ALLERGENS; ANIMALS; ASTHMA; CELL DIFFERENTIATION; CYTOKINES; DENDRITIC CELLS; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; INTERLEUKIN-17; LIPOPOLYSACCHARIDES; LUNG; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; SIGNAL TRANSDUCTION; T-LYMPHOCYTE SUBSETS; TH1 CELLS; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 78149479629     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1001713     Document Type: Article

References (25)

1. Wills-Karp, M., J. Luyimbazi, X. Xu, B. Schofield, T. Y. Neben, C. L. Karp, and D. D. Donaldson. 1998. Interleukin-13: central mediator of allergic asthma. Science 282:2258-2261.
2. Michel, O. 2003. Role of lipopolysaccharide (LPS) in asthma and other pulmonary conditions. J. Endotoxin Res. 9:293-300.
3. Asher, M. I., S. Montefort, B. Björkstén, C. K. Lai, D. P. Strachan, S. K. Weiland, H. Williams; ISAAC Phase Three Study Group. 2006. Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys. Lancet 368:733-743.
4. Kim, Y. K., S. Y. Oh, S. G. Jeon, H. W. Park, S. Y. Lee, E. Y. Chun, B. Bang, H. S. Lee, M. H. Oh, Y. S. Kim, et al. 2007. Airway exposure levels of lipopolysaccharide determine type 1 versus type 2 experimental asthma. J. Immunol. 178:5375-5382.
5. Charan, N. B., E. M. Baile, and P. D. Paré. 1997. Bronchial vascular congestion and angiogenesis. Eur. Respir. J. 10:1173-1180.
6. Hoshino, M., M. Takahashi, and N. Aoike. 2001. Expression of vascular endothelial growth factor, basic fibroblast growth factor, and angiogenin immunoreactivity in asthmatic airways and its relationship to angiogenesis. J. Allergy Clin. Immunol. 107:295-301.
7. de Vries, C., J. A. Escobedo, H. Ueno, K. Houck, N. Ferrara, and L. T. Williams. 1992. The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor. Science 255:989-991.
8. Quinn, T. P., K. G. Peters, C. De Vries, N. Ferrara, and L. T. Williams. 1993. Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium. Proc. Natl. Acad. Sci. USA 90:7533-7537.
9. Voelkel, N. F., R. W. Vandivier, and R. M. Tuder. 2006. Vascular endothelial growth factor in the lung. Am. J. Physiol. Lung Cell. Mol. Physiol. 290: L209-L221.
10. Barleon, B., S. Sozzani, D. Zhou, H. A. Weich, A. Mantovani, and D. Marmé. 1996. Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1. Blood 87:3336-3343.
11. Kim, Y. S., S. W. Hong, J. P. Choi, T. S. Shin, H. G. Moon, E. J. Choi, S. G. Jeon, S. Y. Oh, Y. S. Gho, Z. Zhu, and Y. K. Kim. 2009. Vascular endothelial growth factor is a key mediator in the development of T cell priming and its polarization to type 1 and type 17 T helper cells in the airways. J. Immunol. 183:5113-5120.
12. Bae, D. G., T. D. Kim, G. Li, W. H. Yoon, and C. B. Chae. 2005. Anti-flt1 peptide, a vascular endothelial growth factor receptor 1-specific hexapeptide, inhibits tumor growth and metastasis. Clin. Cancer Res. 11:2651-2661.
13. Vermaelen, K., and R. Pauwels. 2003. Accelerated airway dendritic cell maturation, trafficking, and elimination in a mouse model of asthma. Am. J. Respir. Cell Mol. Biol. 29:405-409.
14. Vermaelen, K. Y., I. Carro-Muino, B. N. Lambrecht, and R. A. Pauwels. 2000. Specific migratory dendritic cells rapidly transport antigen from the airways to the thoracic lymph nodes. J. Exp. Med. 193:51-60.
15. Lee, C. G., H. Link, P. Baluk, R. J. Homer, S. Chapoval, V. Bhandari, M. J. Kang, L. Cohn, Y. K. Kim, D. M. McDonald, and J. A. Elias. 2004. Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung. Nat. Med. 10:1095-1103.
16. Hahn, R. G. 2003. Endotoxin boosts the vascular endothelial growth factor (VEGF) in rabbits. J. Endotoxin Res. 9:97-100.
17. Kim, I., S. O. Moon, S. H. Kim, H. J. Kim, Y. S. Koh, and G. Y. Koh. 2001. Vascular endothelial growth factor expression of intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin through nuclear factor-κB activation in endothelial cells. J. Biol. Chem. 276:7614-7620.
18. Gabrilovich, D. I., H. L. Chen, K. R. Girgis, H. T. Cunningham, G. M. Meny, S. Nadaf, D. Kavanaugh, and D. P. Carbone. 1996. Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells. Nat. Med. 2:1096-1103.
19. Fricke, I., N. Mirza, J. Dupont, C. Lockhart, A. Jackson, J. H. Lee, J. A. Sosman, and D. I. Gabrilovich. 2007. Vascular endothelial growth factor-trap overcomes defects in dendritic cell differentiation but does not improve antigen-specific immune responses. Clin. Cancer Res. 13:4840-4848.
20. Mempel, T. R., S. E. Henrickson, and U. H. Von Andrian. 2004. T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases. Nature 427:154-159.
21. Cyster, J. G. 1999. Chemokines and cell migration in secondary lymphoid organs. Science 286:2098-2102.
22. Sallusto, F., and A. Lanzavecchia. 2000. Understanding dendritic cell and T-lymphocyte traffic through the analysis of chemokine receptor expression. Immunol. Rev. 177:134-140.
23. Idzko, M., H. Hammad, M. van Nimwegen, M. Kool, T. Müller, T. Soullié, M. A. Willart, D. Hijdra, H. C. Hoogsteden, and B. N. Lambrecht. 2006. Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function. J. Clin. Invest. 116:2935-2944.
24. Douwes, J., P. Gibson, J. Pekkanen, and N. Pearce. 2002. Non-eosinophilic asthma: importance and possible mechanisms. Thorax 57:643-648.
25. Boehm, U., T. Klamp, M. Groot, and J. C. Howard. 1997. Cellular responses to interferon-γ. Annu. Rev. Immunol. 15:749-795.