Synthesis and evaluation of the cytotoxicities of tetraindoles: Observation that the 5-hydroxy tetraindole (SK228) induces G2 arrest and apoptosis in human breast cancer cells

Journal of Medicinal Chemistry

Volumn 55, Issue 4, 2012, Pages 1583-1592

  Li, Wen Shan ^a,b   Wang, Chie Hong ^a,b   Ko, Shengkai ^a,c   Chang, Tzu Ting ^a   Jen, Ya Ching ^a   Yao, Ching Fa ^c   More, Shivaji V ^a   Jao, Shu Chuan ^d  

^a INSTITUTE OF CHEMISTRY   (Taiwan)

^b NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

^c NATIONAL TAIWAN NORMAL UNIVERSITY   (Taiwan)

^d INSTITUTE OF BIOLOGICAL CHEMISTRY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

1,3 BIS[DI(1H INDOL 3 YL)METHYL]BENZENE; 1,3 BIS[DI(5 HYDROXY 1H INDOL 3 YL)METHYL]BENZENE; 1,4 BIS[DI(1H INDOL 3 YL)METHYL]BENZENE; 1,4 BIS[DI(5 BROMO 1H INDOL 3 YL)METHYL]BENZENE; 1,4 BIS[DI(5 CYANO 1H INDOL 3 YL)METHYL]BENZENE; 1,4 BIS[DI(5 HYDROXY 1H INDOL 3 YL)METHYL]BENZENE; 1,4 BIS[DI(5 METHOXY 1H INDOL 3 YL)METHYL]BENZENE; 2,5 BIS[DI(1H INDOL 3 YL)METHYL]THIOPHENE; 3 [[[4 DI(1H INDOL 3 YL)METHYL]PHENYL](1H INDOL 3 YL)METHYL](1H INDOLE 5 OL); 3,3' [[[4 DI(1H INDOL 3 YL)METHYL]PHENYL]METHYLENE]BIS(1H INDOLE 5 OL); 3,3' [[[4 DI(1H INDOL 3 YL)METHYL]PHENYL]METHYLENE]BIS(5 BROMO 1H INDOLE); 3,3' [[[4 DI(5 HYDROXY 1H INDOL 3 YL)(1H INDOL 3 YL)METHYL]PHENYL]METHYLENE]BIS(1H INDOL 5 OL); 3,3',3'',3''' [1,4 PHENYLENEBIS(METHANETRIYL)TETRAKIS(1H INDOLE 5 AMINE)]; 3,3',3'',3''' [1,4 PHENYLENEBIS(METHANETRIYL)TETRAKIS(1H INDOLE 6 OL)]; 3,3',3'',3''' [2,2' OXYBIS(2,1 PHENYLENE)BIS(METHANETRIYL)TETRAKIS(1H INDOLE)]; CYCLIN B2; CYCLIN DEPENDENT KINASE 1; INDOLE DERIVATIVE; PHOSPHATIDYLSERINE; SK 228; TETRAINDOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; BREAST ADENOCARCINOMA; BREAST CANCER; CANCER CELL; CANCER CELL CULTURE; CANCER INHIBITION; CANCER SURVIVAL; CYTOTOXICITY; DNA FRAGMENTATION; DRUG STRUCTURE; DRUG SYNTHESIS; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; PROTEIN EXPRESSION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL SURVIVAL; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; G2 PHASE; HUMANS; INDOLES; STRUCTURE-ACTIVITY RELATIONSHIP; XYLENES;

EID: 84863128976     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm2013425     Document Type: Article

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