Polyfluorinated bipyridine cisplatins manipulate cytotoxicity through the induction of S-G 2/M arrest and partial intercalation mechanism

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 16, 2011, Pages 4887-4894

  Chang, Tzu Ting ^a   More, Shivaji V ^a   Lu, Norman ^b   Jhuo, Jyun Wei ^b   Chen, Yi Chuan ^b   Jao, Shu Chuan ^c   Li, Wen Shan ^a,d  

^a INSTITUTE OF CHEMISTRY   (Taiwan)

^b NATIONAL TAIPEI UNIVERSITY OF TECHNOLOGY   (Taiwan)

^c INSTITUTE OF BIOLOGICAL CHEMISTRY   (Taiwan)

^d NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

Author keywords

Anticancer agents; Antiproliferative effect; Cell cycle progression; DNA intercalation mechanism; Polyfluorinated bipyridine cisplatin complexes

Indexed keywords

ANTINEOPLASTIC AGENT; BIPYRIDINE DERIVATIVE; CISPLATIN;

APOPTOSIS; ARTICLE; BREAST ADENOCARCINOMA; CANCER CELL CULTURE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE S PHASE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; FLOW CYTOMETRY; GAS CHROMATOGRAPHY; GEL MOBILITY SHIFT ASSAY; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; INTERCALATION COMPLEX; LIPOPHILICITY; LUNG ADENOCARCINOMA; MASS SPECTROMETRY; STRUCTURE ACTIVITY RELATION; ULTRAVIOLET SPECTROPHOTOMETRY;

ANTINEOPLASTIC AGENTS; CELL CYCLE; CISPLATIN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HALOGENATION; HUMANS; INTERCALATING AGENTS; M PHASE CELL CYCLE CHECKPOINTS; MOLECULAR STRUCTURE; PYRIDINES; S PHASE CELL CYCLE CHECKPOINTS; SOFTWARE; TUMOR CELLS, CULTURED;

EID: 79961171520     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.06.065     Document Type: Article

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