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Volumn 323, Issue 2, 2012, Pages 155-160

DNA damage induces the IL-6/STAT3 signaling pathway, which has anti-senescence and growth-promoting functions in human tumors

Author keywords

DNA damage; IL 6; Senescence; STAT3; Tumor

Indexed keywords

DNA; GLYCOPROTEIN GP 130; INTERLEUKIN 6; JANUS KINASE 1; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; STAT3 PROTEIN;

EID: 84863104297     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2012.04.003     Document Type: Article
Times cited : (60)

References (30)
  • 1
    • 3142534591 scopus 로고    scopus 로고
    • Initiating cellular stress responses
    • Bakkenist C.J., Kastan M.B. Initiating cellular stress responses. Cell 2004, 118:9-17.
    • (2004) Cell , vol.118 , pp. 9-17
    • Bakkenist, C.J.1    Kastan, M.B.2
  • 2
    • 45849099050 scopus 로고    scopus 로고
    • Living on a break: cellular senescence as a DNA-damage response
    • d'Adda di Fagagna F. Living on a break: cellular senescence as a DNA-damage response. Nat. Rev. Cancer 2008, 8:512-522.
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 512-522
    • d'Adda di Fagagna, F.1
  • 5
    • 34548186667 scopus 로고    scopus 로고
    • Cellular senescence. when bad things happen to good cells
    • Campisi J., d'Adda di Fagagna F. Cellular senescence. when bad things happen to good cells. Nat. Rev. Mol. Cell Biol. 2007, 8:729-740.
    • (2007) Nat. Rev. Mol. Cell Biol. , vol.8 , pp. 729-740
    • Campisi, J.1    d'Adda di Fagagna, F.2
  • 6
    • 23944483417 scopus 로고    scopus 로고
    • IL-6: from laboratory to bedside
    • Kishimoto T. IL-6: from laboratory to bedside. Clin. Rev. Allergy Immunol. 2005, 28:177-186.
    • (2005) Clin. Rev. Allergy Immunol. , vol.28 , pp. 177-186
    • Kishimoto, T.1
  • 8
    • 46449136003 scopus 로고    scopus 로고
    • Deregulation of Cdk2 causes bim-mediated apoptosis in p53-deficient tumors following actin damage
    • Chae H.D., Kim B.M., Yun U.J., Shin D.Y. Deregulation of Cdk2 causes bim-mediated apoptosis in p53-deficient tumors following actin damage. Oncogene 2008.
    • (2008) Oncogene
    • Chae, H.D.1    Kim, B.M.2    Yun, U.J.3    Shin, D.Y.4
  • 9
    • 34447506658 scopus 로고    scopus 로고
    • Oncogenic ras-induced secretion of IL6 is required for tumorigenesis
    • Ancrile B., Lim K.H., Counter C.M. Oncogenic ras-induced secretion of IL6 is required for tumorigenesis. Genes Dev. 2007, 21:1714-1719.
    • (2007) Genes Dev. , vol.21 , pp. 1714-1719
    • Ancrile, B.1    Lim, K.H.2    Counter, C.M.3
  • 11
    • 0035313701 scopus 로고    scopus 로고
    • The stat family in cytokine signaling
    • Ihle J.N. The stat family in cytokine signaling. Curr. Opin. Cell Biol. 2001, 13:211-217.
    • (2001) Curr. Opin. Cell Biol. , vol.13 , pp. 211-217
    • Ihle, J.N.1
  • 12
    • 0030890718 scopus 로고    scopus 로고
    • Gp130 and the interleukin-6 family of cytokines
    • Taga T., Kishimoto T. Gp130 and the interleukin-6 family of cytokines. Annu. Rev. Immunol. 1997, 15:797-819.
    • (1997) Annu. Rev. Immunol. , vol.15 , pp. 797-819
    • Taga, T.1    Kishimoto, T.2
  • 13
    • 0029960028 scopus 로고    scopus 로고
    • Dominant negative stat3 mutant inhibits interleukin-6-induced Jak-STAT signal transduction
    • Kaptein A., Paillard V., Saunders M. Dominant negative stat3 mutant inhibits interleukin-6-induced Jak-STAT signal transduction. J. Biol. Chem. 1996, 271:5961-5964.
    • (1996) J. Biol. Chem. , vol.271 , pp. 5961-5964
    • Kaptein, A.1    Paillard, V.2    Saunders, M.3
  • 15
    • 2342431845 scopus 로고    scopus 로고
    • Bcl-xL and E1B-19K proteins inhibit p53-induced irreversible growth arrest and senescence by preventing reactive oxygen species-dependent p38 activation
    • Jung M.S., Jin D.H., Chae H.D., Kang S., Kim S.C., Bang Y.J., Choi T.S., Choi K.S., Shin D.Y. Bcl-xL and E1B-19K proteins inhibit p53-induced irreversible growth arrest and senescence by preventing reactive oxygen species-dependent p38 activation. J. Biol. Chem. 2004, 279:17765-17771.
    • (2004) J. Biol. Chem. , vol.279 , pp. 17765-17771
    • Jung, M.S.1    Jin, D.H.2    Chae, H.D.3    Kang, S.4    Kim, S.C.5    Bang, Y.J.6    Choi, T.S.7    Choi, K.S.8    Shin, D.Y.9
  • 16
    • 0030886015 scopus 로고    scopus 로고
    • Wild-type p53 triggers a rapid senescence program in human tumor cells lacking functional p53
    • Shin D.Y., Sugrue M.M., Lee S.W., Aaronson S.A. Wild-type p53 triggers a rapid senescence program in human tumor cells lacking functional p53. Proc. Natl. Acad. Sci. USA 1997, 94:9648-9653.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 9648-9653
    • Shin, D.Y.1    Sugrue, M.M.2    Lee, S.W.3    Aaronson, S.A.4
  • 17
    • 0034523514 scopus 로고    scopus 로고
    • Appearance of biomarkers of in vitro ageing after successive stimulation of WI-38 fibroblasts with IL-1alpha and TNF-alpha: senescence associated beta-galactosidase activity and morphotype transition
    • Dumont P., Balbeur L., Remacle J., Toussaint O. Appearance of biomarkers of in vitro ageing after successive stimulation of WI-38 fibroblasts with IL-1alpha and TNF-alpha: senescence associated beta-galactosidase activity and morphotype transition. J. Anat. 2000, 197(Pt 4):529-537.
    • (2000) J. Anat. , vol.197 , Issue.PART 4 , pp. 529-537
    • Dumont, P.1    Balbeur, L.2    Remacle, J.3    Toussaint, O.4
  • 18
    • 0028088709 scopus 로고
    • Overexpression of plasminogen activator inhibitor type-1 in senescent fibroblasts from normal subjects and those with Werner syndrome
    • Goldstein S., Moerman E.J., Fujii S., Sobel B.E. Overexpression of plasminogen activator inhibitor type-1 in senescent fibroblasts from normal subjects and those with Werner syndrome. J. Cell Physiol. 1994, 161:571-579.
    • (1994) J. Cell Physiol. , vol.161 , pp. 571-579
    • Goldstein, S.1    Moerman, E.J.2    Fujii, S.3    Sobel, B.E.4
  • 19
    • 27544476971 scopus 로고    scopus 로고
    • The role of IL-6 and STAT3 in inflammation and cancer
    • Hodge D.R., Hurt E.M., Farrar W.L. The role of IL-6 and STAT3 in inflammation and cancer. Eur. J. Cancer 2005, 41:2502-2512.
    • (2005) Eur. J. Cancer , vol.41 , pp. 2502-2512
    • Hodge, D.R.1    Hurt, E.M.2    Farrar, W.L.3
  • 24
    • 77958501473 scopus 로고    scopus 로고
    • DNA damage-mediated induction of a chemoresistant niche
    • Gilbert L.A., Hemann M.T. DNA damage-mediated induction of a chemoresistant niche. Cell 2010, 143:355-366.
    • (2010) Cell , vol.143 , pp. 355-366
    • Gilbert, L.A.1    Hemann, M.T.2
  • 25
    • 35648995976 scopus 로고    scopus 로고
    • Interleukin-6 and its receptor in cancer: implications for translational therapeutics
    • Hong D.S., Angelo L.S., Kurzrock R. Interleukin-6 and its receptor in cancer: implications for translational therapeutics. Cancer 2007, 110:1911-1928.
    • (2007) Cancer , vol.110 , pp. 1911-1928
    • Hong, D.S.1    Angelo, L.S.2    Kurzrock, R.3
  • 26
    • 34548841964 scopus 로고    scopus 로고
    • Cytokine-dependent imatinib resistance in mouse BCR-ABL+, Arf-null lymphoblastic leukemia
    • Williams R.T., den Besten W., Sherr C.J. Cytokine-dependent imatinib resistance in mouse BCR-ABL+, Arf-null lymphoblastic leukemia. Genes Dev. 2007, 21:2283-2287.
    • (2007) Genes Dev. , vol.21 , pp. 2283-2287
    • Williams, R.T.1    den Besten, W.2    Sherr, C.J.3
  • 28
    • 33748188499 scopus 로고    scopus 로고
    • PIASy mediates NEMO sumoylation and NF-kappaB activation in response to genotoxic stress
    • Mabb A.M., Wuerzberger-Davis S.M., Miyamoto S. PIASy mediates NEMO sumoylation and NF-kappaB activation in response to genotoxic stress. Nat. Cell Biol. 2006, 8:986-993.
    • (2006) Nat. Cell Biol. , vol.8 , pp. 986-993
    • Mabb, A.M.1    Wuerzberger-Davis, S.M.2    Miyamoto, S.3
  • 29
    • 3042523535 scopus 로고    scopus 로고
    • Activation of transcription factor NF-kappaB requires ELKS, an IkappaB kinase regulatory subunit
    • Ducut Sigala J.L., Bottero V., Young D.B., Shevchenko A., Mercurio F., Verma I.M. Activation of transcription factor NF-kappaB requires ELKS, an IkappaB kinase regulatory subunit. Science 2004, 304:1963-1967.
    • (2004) Science , vol.304 , pp. 1963-1967
    • Ducut Sigala, J.L.1    Bottero, V.2    Young, D.B.3    Shevchenko, A.4    Mercurio, F.5    Verma, I.M.6
  • 30
    • 33644538632 scopus 로고    scopus 로고
    • Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuli
    • Wu Z.H., Shi Y., Tibbetts R.S., Miyamoto S. Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuli. Science 2006, 311:1141-1146.
    • (2006) Science , vol.311 , pp. 1141-1146
    • Wu, Z.H.1    Shi, Y.2    Tibbetts, R.S.3    Miyamoto, S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.