Inflammatory cytokines modulate chemokine production patterns of HepG2 cells toward initially inclined direction

Hepatology Research

Volumn 39, Issue 5, 2009, Pages 510-519

  Ohashi, Tomohiko ^a   Tanabe, Junichi ^b   Ishikawa, Tetsuya ^c   Okumura, Akihiko ^d   Sato, Ken ^a   Ayada, Minoru ^e   Hotta, Naoki ^e   Kuzuya, Teiji ^c   Ito, Hiroyasu ^f   Nakao, Haruhisa ^a   Yoneda, Masashi ^a   Kakumu, Shinichi ^a  

^a AICHI MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TORAY INDUSTRIES INC   (Japan)

^c NAGOYA KYORITSU HOSPITAL   (Japan)

^d Kainan Hospital   (Japan)

^e Masuko Memorial Hospital   (Japan)

^f GIFU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Chemokine; Cytokine; Hepatitis; Hepatocyte; Th1; Th2

Indexed keywords

CXCL9 CHEMOKINE; CYTOKINE; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 1ALPHA; INTERLEUKIN 4; INTERLEUKIN 8; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1;

ARTICLE; CELL FUNCTION; CELL STIMULATION; CELL STRAIN HEPG2; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; LIVER CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TH1 CELL; TH2 CELL; UPREGULATION;

EID: 65449153256     PISSN: 13866346     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1872-034X.2008.00482.x     Document Type: Article

References (55)

1. Wanless IR. Physioanatomic considerations. In: Schiff ER, Sorrell MF, Maddrey WC, eds. Schiff's Diseases of the Liver, 8th edn. Philadelphia, PA: Lippincott-Raven Publishers, 1998; 16.
2. Rowell DL, Eckmann L, Dwinell MB et al. Human hepatocytes express an array of proinflammatory cytokines after agonist stimulation or bacterial invasion. Am J Physiol 1997; 273: G322-32.
3. Wegenka UM, Buschmann J, Lütticken C, Heinrich PC, Horn F. Acute-phase response factor, a nuclear factor binding to acute-phase response elements, is rapidly activated by interleukin-6 at the posttranslational level. Mol Cell Biol 1993; 13: 276-88.
4. Moshage H. Cytokines and the hepatic acute phase response. J Pathol 1999; 181: 257-66.
5. Mackay CR. Chemokine receptors and T-cell chemotaxis. J Exp Med 1996; 184: 799-802.
6. Adams DH, Lloyd AR. Chemokines: Leukocyte recruitment and activation cytokines. Lancet 1997; 349: 490-5.
7. Luster AD. Chemokines-chemotactic cytokines that mediate inflammation. N Engl J Med 1998; 338: 436-45.
8. Charo IF, Ransohoff RM. The many roles of chemokines and chemokine receptors in inflammation. N Engl J Med 2006; 354: 610-21.
9. Mantovani A. The chemokine system: Redundancy for robust outputs. Immunol Today 1999; 20: 254-7.
10. Allen SJ, Crown SE, Handel TM. Chemokine: Receptor structure, interactions, and antagonism. Annu Rev Immunol 2007; 25: 787-820.
11. Loetscher M, Gerber B, Loetscher P et al. Chemokine receptor specific for IP10 and mig: Structure, function, and expression in activated T-lymphocytes. J Exp Med 1996; 184: 799-802.
12. Bonecchi R, Bianchi G, Bordignon PP et al. Differential expression of chemokine receptors and chemotactic responsiveness of Type 1 T helper cells (Th1s) and Th2s. J Exp Med 1998; 187: 129-34.
13. Sallusto F, Lanzavecchia A, Mackay CR. Chemokines and chemokine receptors in T-cell priming and Th1/Th2-mediated responses. Immunol Today 1998; 19: 568-74.
14. Kim CH, Rott L, Kunkel EJ et al. Rules of chemokine receptor association with T cell polarization in vivo. J Clin Invest 2001; 108: 1331-9.
15. Baba M, Imai T, Yoshida T, Yoshie O. Constitutive expression of various chemokine genes in human T-cell lines infected with human T-cell leukemia virus type 1: Role of the viral transactivator Tax. Int J Cancer 1996; 66: 124-9.
16. Teruya-Feldstein J, Jaffe ES, Burd PR, Kingma DW, Setsuda JE, Tosato G. Differential chemokine expression in tissues involved by Hodgkin's disease: Direct correlation of eotaxin expression and tissue eosinophilia. Blood 1999; 93: 2463-70.
17. Hayes IM, Jordan NJ, Towers S et al. Human vascular smooth muscle cells express receptors for CC chemokines. Arterioscler Thromb Vasc Biol 1998; 18: 397-403.
18. Yoshida T, Imai T, Takagi S et al. Structure and expression of two highly related genes encoding SCM-1/human lymphotactin. FEBS Lett 1996; 395: 82-8.
19. Schnyder B, Lugli S, Feng N et al. Interleukin-4 (IL-4) and IL-13 bind to a shared heterodimeric complex on endothelial cells mediating vascular cell adhesion molecule-1 induction in the absence of the common gamma chain. Blood 1996; 87: 4286-95.
20. Michel G, Mirmohammadsadegh A, Olasz E et al. Demonstration and functional analysis of IL-10 receptors in human epidermal cells: decreased expression in psoriatic skin, down-modulation by IL-8, and up-regulation by an antipsoriatic glucocorticosteroid in normal cultured keratinocytes. J Immunol 1997; 159: 6291-7.
21. Harasawa H, Yamada Y, Hieshima K et al. Survey of chemokine receptor expression reveals frequent co-expression of skin-homing CCR4 and CCR10 in adult T-cell leukemia/lymphoma. Leuk Lymphoma 2006; 47: 2163-73.
22. Kotowicz K, Callard RE, Friedrich K, Matthews DJ, Klein N. Biological activity of IL-4 and IL-13 on human endothelial cells: Functional evidence that both cytokines act through the same receptor. Int Immunol 1996; 8: 1915-25.
23. Robbins M, McKinney M. Transcriptional regulation of neuromodulin (GAP-43) in mouse neuroblastoma clone N1E-115 as evaluated by the RT/PCR method. Brain Res Mol Brain Res 1992; 13: 83-92.
24. Schall TJ, Bacon K, Toy KJ, Goeddel DV. Selective attraction of monocytes and T lymphocytes of the memory phenotype by cytokine RANTES. Nature 1990; 347: 669-71.
25. Fukada K, Sobao Y, Tomiyama H, Oka S, Takiguchi M. Functional expression of the chemokine receptor CCR5 on virus epitope-specific memory and effector CD8+ T cells. J Immunol 2002; 168: 2225-32.
26. Bonecchi R, Sozzani S, Stine JT et al. Divergent effects of interleukin-4 and interferon-gamma on macrophage-derived chemokine production: An amplification circuit of polarized T helper 2 responses. Blood 1998; 92: 2668-71.
27. Wang H, Nemoto-Sasaki Y, Kondo T, Akiyama M, Mukaida N. Potential involvement of monocyte chemoattractant protein (MCP)-1/CCL2 in IL-4-mediated tumor immunity through inducing dendritic cell migration into the draining lymph nodes. Int Immunopharmacol 2003; 3: 627-42.
28. Mantovani A, Sica A, Sozzani S, Allavena P, Vecchi A, Locati M. The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol 2004; 25: 677-86.
29. Seitz M, Loetscher P, Dewald B, Towbin H, Gallati H, Baggiolini M. Interleukin-10 differentially regulates cytokine inhibitor and chemokine release from blood mononuclear cells and fibroblasts. Eur J Immunol 1995; 25: 1129-32.
30. Mosmann TR, Coffman RL. TH1 and TH2 cells: Different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 1989; 7: 145-73.
31. Kidd P. Th1/Th2 balance: The hypothesis, its limitations, and implications for health and disease. Altern Med Rev 2003; 8: 223-46.
32. Bergmann C, Van Hemmen JL, Segel LA. Th1 or Th2: How an Appropriate T helper response can be made. Bull Math Biol 2001; 63: 405-30.
33. Dumont FJ. Modulation of Th1 and Th2 responses for immunotherapy. Expert Opin Ther Patents 2002; 12: 341-67.
34. Enosawa S, Miyashita T, Fujita Y et al. In vivo estimation of bioartificial liver with recombinant HepG2 cells using pigs with ischemic liver failure. Cell Transplant 2001; 10: 429-33.
35. Bouma ME, Rogier E, Verthier N, Labarre C, Feldmann G. Further cellular investigation of the human hepatoblastoma-derived cell line HepG2: morphology and immunocytochemical studies of hepatic-secreted proteins. In Vitro Cell Dev Biol 1989; 25: 267-75.
36. Maltby J, Wright S, Bird G, Sheron N. Chemokine levels in human liver homogenates: Associations between GRO alpha and histopathological evidence of alcoholic hepatitis. Hepatology 1996; 24: 1156-60.
37. Bautista A. Neutrophilic infiltration in alcoholic hepatitis. Alcohol 2002; 27: 17-21.
38. Narumi S, Tominaga Y, Tamaru M et al. Expression of IFN-inducible protein-10 in chronic hepatitis. J Immunol 1997; 158: 5536-44.
39. Harvey CH, Post JJ, Palladinetti P et al. Expression of the chemokine IP-10 (CXCL10) by hepatocytes in chronic hepatitis C virus infection correlates with histological severity and lobular inflammation. J Leukoc Biol 2003; 74: 360-9.
40. Fukada K, Sobao Y, Tomiyama H, Oka S, Takiguchi M. Functional expression of the chemokine receptor CCR5 on virus epitope-specific memory and effector CD8+ T cells. J Immunol 2002; 168: 2225-32.
41. Ip WK, Wong CK, Lam CW. Interleukin (IL)-4 and IL-13 up-regulate monocyte chemoattractant protein-1 expression in human bronchial epithelial cells: Involvement of p38 mitogen-activated protein kinase, extracellular signal-regulated kinase 1/2 and Janus kinase-2 but not c-Jun NH2-terminal kinase 1/2 signalling pathways. Clin Exp Immunol 2006; 145: 162-72.
42. Musso T, Cappello P, Stornello S et al. IL-10 enhances CCL2 release and chemotaxis induced by CCL16 in human monocytes. Int J Immunopathol Pharmacol 2005; 18: 339-49.
43. Yoshimura H, Nakahama K, Safronova O, Tanaka N, Muneta T, Morita I. Transforming growth factor-β stimulates IL-1β-induced monocyte chemoattractant protein-1 expression in human synovial cells via the ERK/ AP-1 pathway. Inflamm Res 2006; 55: 543-9.
44. Gu L, Tseng S, Horner RM, Tam C, Loda M, Rollins BJ. Control of TH2 polarization by the chemokine monocyte chemoattractant protein-1. Nature 2000; 404: 407-11.
45. Decker K. Biologically active products of stimulated liver macrophages (Kupffer cells). Eur J Biochem 2004; 192: 245-61.
46. Nagy LE. Recent insights into the role of the innate immune system in the development of alcoholic liver disease. Exp Biol Med 2003; 228: 882-90.
47. Roberts RA, Ganey PE, Ju C, Kamendulis LM, Rusyn I, Klaunig JE. Role of the kupffer cell in mediating hepatic toxicity and carcinogenesis. Toxicol Sci 2007; 96: 2-15.
48. Bautista AP. Chronic alcohol intoxication primes Kupffer cells and endothelial cells for enhanced CC-chemokine production and concomitantly suppresses phagocytosis and chemotaxis. Front Biosci 2002; 7: A117-25.
49. Valatas V, Kolios G, Manousou P et al. Octreotide regulates CC but not CXC LPS-induced chemokine secretion in rat Kupffer cells. Br J Pharmacol 2004; 141: 477-87.
50. Kopydlowski KM, Salkowski CA, Cody MJ et al. Regulation of macrophage chemokine expression by lipopolysaccharide in vitro and in vivo. J Immunol 1999; 1537-44.
51. Shields PL, Morland CM, Salmon M, Qin S, Hubscher SG, Adams DH. Chemokine and chemokine receptor interactions provide a mechanism for selective T cell recruitment to specific liver compartments within hepatitis C-infected liver. J Immunol 1999; 163: 6236-43.
52. Gupta SK, Lysko PG, Pillarisetti K, Ohlstein E, Stadel JM. Chemokine Receptors in human endothelial cells: Functional expression of CXCR4 and its transcriptional regulation by inflammatory cytokines. J Biol Chem 1998; 273: 4282-87.
53. Duryee MJ, Klassen LW, Freeman TL et al. Lipopolysaccharide is a cofactor for malondialdehyde-acetaldehyde adduct-mediated cytokine/ chemokine release by rat sinusoidal liver endothelial and Kupffer cells. Alcohol Clin Exp Res 2004; 28: 1931-8.
54. Kim CH, Johnston B, Butcher EC. Trafficking machinery of NKT cells: shared and differential chemokine receptor expression among Vα24+ Vβ11+ NKT cell subsets with distinct cytokine-producing capacity. Blood 2002; 100: 11-16.
55. Thomas SY, Hou R, Boyson JE et al. CD1d-restricted NKT cells express a chemokine receptor profile indicative of Th1-type inflammatory homing cells. J Immunol 2003; 171: 2571-80.