Ventilator-induced lung injury: The anatomical and physiological framework

Critical Care Medicine

Volumn 38, Issue 10 SUPPL., 2010, Pages

  Gattinoni, Luciano ^a,b   Protti, Alessandro ^a   Caironi, Pietro ^a,b   Carlesso, Eleonora ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

Author keywords

Acute lung injury; Acute respiratory distress syndrome; Chest wall elastance; Lung elastance; Lung mechanics; Lung strain; Lung stress; Lung volumes; Transpulmonary pressure; Ventilator induced lung injury

Indexed keywords

INTERLEUKIN 6;

AIRWAY PRESSURE; ARTIFICIAL VENTILATION; CONFERENCE PAPER; DISEASE PREDISPOSITION; HUMAN; LUNG ALVEOLUS CELL; LUNG BAROTRAUMA; LUNG EDEMA; LUNG VOLUTRAUMA; PATHOPHYSIOLOGY; PNEUMOTHORAX; POSITIVE END EXPIRATORY PRESSURE; PRIORITY JOURNAL; RESPIRATORY DISTRESS; THORAX RADIOGRAPHY; TIDAL VOLUME; TOTAL LUNG CAPACITY; VENTILATOR INDUCED LUNG INJURY;

EID: 78650357466     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e3181f1fcf7     Document Type: Conference Paper

References (69)

1. Cournand A, Motley HL, Werkö L, et al: Physiological studies of the effects of intermittent positive pressure breathing on cardiac output in man. Am J Physiol 1948;152:162-174
2. Frank L, Bucher JR, Roberts RJ: Oxygen tox-icity in neonatal and adult animals of various species. J Appl Physiol 1978;45:699-704
3. Pontoppidan H, Geffin B, Lowenstein E: Acute respiratory failure in the adult: 3. N Engl J Med 1972;287:799-806
4. Kirby RR, Downs JB, Civetta JM, et al: High level positive end expiratory pressure (PEEP) in acute respiratory insufficiency. Chest 1975;67:156-163
5. Labrousse J, Tenaillon A, Longchal J, et al: Optimal expiratory positive pressure during artificial ventilation: Application in the treatment of respiratory distress syndrome in the adult. Nouv Presse Med 1979;8:759-763 (Pubitemid 9138678)
6. Dellinger RP, Levy MM, Carlet JM, et al: Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med 2008;36:296-327
7. Zapol WM, Snider MT, Hill JD, et al: Extra-corporeal membrane oxygenation in severe acute respiratory failure: A randomized prospective study. JAMA 1979;242:2193-2196
8. Hager DN, Krishnan JA, Hayden DL, et al: Tidal volume reduction in patients with acute lung injury when plateau pressures are not high. Am J Respir Crit Care Med 2005;172:1241-1245
9. Kumar A, Pontoppidan H, Falke KJ, et al: Pulmonary barotrauma during mechanical ventilation. Crit Care Med 1973;1:181-186
10. Tagliabue M, Casella TC, Zincone GE, et al: CT and chest radiography in the evaluation of adult respiratory distress syndrome. Acta Radiol 1994;35:230-234
11. Marini JJ, Culver BH: Systemic gas embolism complicating mechanical ventilation in the adult respiratory distress syndrome. Ann Intern Med 1989;110:699-703
12. Dreyfuss D, Soler P, Basset G, et al: High inflation pressure pulmonary edema: Respective effects of high airway pressure, high tidal volume, and positive end-expiratory pressure. Am Rev Respir Dis 1988;137:1159-1164
13. Chiumello D, Carlesso E, Cadringher P, et al: Lung stress and strain during mechanical ventilation for acute respiratory distress syndrome. Am J Respir Crit Care Med 2008;178:346-355
14. Agostoni E, Hyatt R: Static behavior of the respiratory system. In: Handbook of Physiology: The Respiratory System Mechanics of Breathing. Bethesda, MD. American Physiology Society, 1986, pp 113-130
15. Uhlig S: Ventilation-induced lung injury and mechanotransduction: Stretching it too far? Am J Physiol Lung Cell Mol Physiol 2002;282: L892-L896
16. Pugin J: Molecular mechanisms of lung cell activation induced by cyclic stretch. Crit Care Med 2003;31: S200-S206
17. Dos Santos CC, Slutsky AS: Mechanisms of ventilator-induced lung injury: A perspective. J Appl Physiol 2000;89:1645-1655
18. Tremblay L, Valenza F, Ribeiro SP, et al: Injurious ventilatory strategies increase cy-tokines and c-fos m-RNA expression in an isolated rat lung model. J Clin Invest 1997;99:944-952
19. Muscedere JG, Mullen JB, Gan K, et al: Tidal ventilation at low airway pressures can augment lung injury. Am J Respir Crit Care Med 1994;149:1327-1334
20. Mead J, Takishima T, Leith D: Stress distribution in lungs: A model of pulmonary elasticity. J Appl Physiol 1970;28:596-608
21. Lachmann B: Open up the lung and keep the lung open. Intensive Care Med 1992;18:319-321
22. Weibel ER: Functional morphology of lung parenchyma. In: Handbook of Physiology: A Critical, Comprehensive Presentation of Physiological Knowledge and Concepts. American Physiological Society (Ed). Baltimore, MD. Waverly Press, 1986, pp 89-111
23. Gattinoni L, Carlesso E, Cadringher P, et al: Physical and biological triggers of ventilator-induced lung injury and its prevention. Eur Respir J Suppl 2003;47:15s-25s
24. Maksym GN, Bates JH: A distributed nonlinear model of lung tissue elasticity. J Appl Physiol 1997;82:32-41
25. Maksym GN, Fredberg JJ, Bates JH: Force heterogeneity in a two-dimensional network model of lung tissue elasticity. J Appl Physiol 1998;85:1223-1229
26. West JB: Invited review: Pulmonary capillary stress failure. J Appl Physiol 2000;89:2483-2489
27. Kolobow T, Moretti MP, Fumagalli R, et al: Severe impairment in lung function induced by high peak airway pressure during mechanical ventilation: An experimental study. Am Rev Respir Dis 1987;135:312-315
28. Broccard AF, Shapiro RS, Schmitz LL, et al: Influence of prone position on the extent and distribution of lung injury in a high tidal volume oleic acid model of acute respiratory distress syndrome. Crit Care Med 1997;25:16-27
29. Stocks J, Quanjer PH: Reference values for residual volume, functional residual capacity and total lung capacity. ATS Workshop on Lung Volume Measurements Official Statement of the European Respiratory Society. Eur Respir J 1995;8:492-506
30. Ibanez J, Raurich JM: Normal values of functional residual capacity in the sitting and supine positions. Intensive Care Med 1982;8:173-177
31. Gattinoni L, Pesenti A, Avalli L, et al: Pressure-volume curve of total respiratory system in acute respiratory failure: Computed tomographic scan study. Am Rev Respir Dis 1987;136:730-736
32. Gattinoni L, Caironi P, Cressoni M, et al: Lung recruitment in patients with the acute respiratory distress syndrome. N Engl J Med 2006;354:1775-1786
33. Gattinoni L, Pesenti A: The concept of "baby lung." Intensive Care Med 2005;31:776-784
34. Bellani G, Messa C, Guerra L, et al: Lungs of patients with acute respiratory distress syndrome show diffuse inflammation in normally aerated regions: A [18F]-fluoro-2-deoxy-D-glucose PET/CT study. Crit Care Med 2009;37:2216-2222
35. Pelosi P, Goldner M, McKibben A, et al: Recruitment and derecruitment during acute respiratory failure: An experimental study. Am J Respir Crit Care Med 2001;164:122-130 (Pubitemid 33151309)
36. Crotti S, Mascheroni D, Caironi P, et al: Recruitment and derecruitment during acute respiratory failure: A clinical study. Am J Respir Crit Care Med 2001;164:131-140 (Pubitemid 33151310)
37. Amato MB, Barbas CS, Medeiros DM, et al: Effect of a protective- ventilation strategy on mortality in the acute respiratory distress syndrome. N Engl J Med 1998;338:347-354
38. Villar J, Kacmarek RM, Perez-Mendez L, et al: A high positive end-expiratory pressure, low tidal volume ventilatory strategy improves outcome in persistent acute respiratory distress syndrome: A randomized, controlled trial. Crit Care Med 2006;34:1311-1318
39. Ranieri VM, Suter PM, Tortorella C, et al: Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome: A randomized controlled trial. JAMA 1999;282:54-61
40. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network. N Engl J Med 2000;342:1301-1308
41. Brochard L, Roudot-Thoraval F, Roupie E, et al: Tidal volume reduction for prevention of ventilator-induced lung injury in acute respiratory distress syndrome. The Multicenter Trail Group on Tidal Volume reduction in ARDS. Am J Respir Crit Care Med 1998;158:1831-1838
42. Stewart TE, Meade MO, Cook DJ, et al: Evaluation of a ventilation strategy to prevent barotrauma in patients at high risk for acute respiratory distress syndrome. Pressure-and Volume-Limited Ventilation Strategy Group. N Engl J Med 1998;338:355-361
43. Brower RG, Lanken PN, MacIntyre N, et al: Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome. N Engl J Med 2004;351:327-336
44. Mercat A, Richard JC, Vielle B, et al: Positive end-expiratory pressure setting in adults with acute lung injury and acute respiratory distress syndrome: A randomized controlled trial. JAMA 2008;299:646-655
45. Meade MO, Cook DJ, Guyatt GH, et al: Ventilation strategy using low tidal volumes, recruitment maneuvers, and high positive end-expiratory pressure for acute lung injury and acute respiratory distress syndrome: A randomized controlled trial. JAMA 2008;299:637-645
46. Gattinoni L, Caironi P: Refining ventilatory treatment for acute lung injury and acute respiratory distress syndrome. JAMA 2008;299:691-693 (Pubitemid 351252730)
47. Phoenix SI, Paravastu S, Columb M, et al: Does a higher positive end expiratory pressure decrease mortality in acute respiratory distress syndrome? A systematic review and meta-analysis. Anesthesiology 2009;110:1098-1105
48. Putensen C, Theuerkauf N, Zinserling J, et al: Meta-analysis: Ventilation strategies and outcomes of the acute respiratory distress syndrome and acute lung injury. Ann Intern Med 2009;151:566-576
49. Gajic O, Dara SI, Mendez JL, et al: Ventilator-associated lung injury in patients without acute lung injury at the onset of mechanical ventilation. Crit Care Med 2004;32:1817-1824
50. Gajic O, Frutos-Vivar F, Esteban A, et al: Ventilator settings as a risk factor for acute respiratory distress syndrome in mechanically ventilated patients. Intensive Care Med 2005;31:922-926
51. Wrigge H, Uhlig U, Zinserling J, et al: The effects of different ventilatory settings on pulmonary and systemic inflammatory responses during major surgery. Anesth Analg 2004;98:775-81
52. Wrigge H, Uhlig U, Baumgarten G, et al: Mechanical ventilation strategies and inflammatory responses to cardiac surgery: A prospective randomized clinical trial. Intensive Care Med 2005;31:1379-1387
53. Choi G, Wolthuis EK, Bresser P, et al: Mechanical ventilation with lower tidal volumes and positive end-expiratory pressure prevents alveolar coagulation in patients without lung injury. Anesthesiology 2006;105:689-695
54. Determann RM, Royakkers A, Wolthuis EK, et al: Ventilation with lower tidal volumes as compared to conventional tidal volumes for patients without acute lung injury-A preventive randomized controlled trial. Crit Care 2010;14: R1
55. Greenfield LJ, Ebert PA, Benson DW: Effect of positive pressure ventilation on surface tension properties of lung extracts. Anesthe-siology 1964;25:312-316
56. Webb HH, Tierney DF: Experimental pulmonary edema due to intermittent positive pressure ventilation with high inflation pressures. Protection by positive end-expiratory pressure. Am Rev Respir Dis 1974;110:556-565
57. Dreyfuss D, Basset G, Soler P, et al: Intermittent positive-pressure hyperventilation with high inflation pressures produces pulmonary microvascular injury in rats. Am Rev Respir Dis 1985;132:880-884
58. Imai Y, Kawano T, Iwamoto S, et al: Intra-tracheal anti-tumor necrosis factor-alpha antibody attenuates ventilator-induced lung injury in rabbits. J Appl Physiol 1999;87:510-515
59. Chiumello D, Pristine G, Slutsky AS: Mechanical ventilation affects local and systemic cytokines in an animal model of acute respiratory distress syndrome. Am J Respir Crit Care Med 1999;160:109-116
60. Ranieri VM, Zhang H, Mascia L, et al: Pressure-time curve predicts minimally injurious ventilatory strategy in an isolated rat lung model. Anesthesiology 2000;93:1320-1328
61. Sibilla S, Tredici S, Porro A, et al: Equal increases in respiratory system elastance reflect similar lung damage in experimental ventilator-induced lung injury. Intensive Care Med 2002;28:196-203
62. Belperio JA, Keane MP, Burdick MD, et al: Critical role for CXCR2 and CXCR2 ligands during the pathogenesis of ventilator-induced lung injury. J Clin Invest 2002;110:1703-1716
63. Gajic O, Lee J, Doerr CH, et al: Ventilator-induced cell wounding and repair in the intact lung. Am J Respir Crit Care Med 2003;167:1057-1063
64. Imai Y, Parodo J, Kajikawa O, et al: Injurious mechanical ventilation and end-organ epithelial cell apoptosis and organ dysfunction in an experimental model of acute respiratory distress syndrome. JAMA 2003;289:2104-2112
65. Wilson MR, Choudhury S, Takata M: Pulmonary inflammation induced by high-stretch ventilation is mediated by tumor necrosis factor signaling in mice. Am J Physiol Lung Cell Mol Physiol 2005;288: L599-L607
66. Caironi P, Ichinose F, Liu R, et al: 5-Lipoxy-genase deficiency prevents respiratory failure during ventilator-induced lung injury. Am J Respir Crit Care Med 2005;172:334-343
67. Dreyfuss D, Saumon G: Role of tidal volume, FRC, and end-inspiratory volume in the development of pulmonary edema following mechanical ventilation. Am Rev Respir Dis 1993;148:1194-1203
68. Valenza F, Guglielmi M, Irace M, et al: Positive end-expiratory pressure delays the progression of lung injury during ventilator strategies involving high airway pressure and lung overdistention. Crit Care Med 2003;31:1993-1998
69. Brower RG, Shanholtz CB, Fessler HE, et al: Prospective, randomized, controlled clinical trial comparing traditional versus reduced tidal volume ventilation in acute respiratory distress syndrome patients. Crit Care Med 1999;27:1492-1498