Normal human immunoglobulin G4 is bispecific: It has two different antigen-combining sites

Immunology

Volumn 97, Issue 4, 1999, Pages 693-698

  Schuurman, J ^a   Van Ree, R ^a   Perdok, G J ^a   Van Doorn, H R ^b   Tan, K Y ^a   Aalberse, R C ^a,c  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b Schieland Hospital   (Netherlands)

^c CENTRAL LABORATORY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN G4;

ANTIBODY COMBINING SITE; ANTIBODY SPECIFICITY; ANTIGEN BINDING; ARTICLE; CONTROLLED STUDY; CROSS LINKING; HUMAN; MOLECULAR INTERACTION; MOLECULAR RECOGNITION; PRIORITY JOURNAL;

ALLERGENS; ANIMALS; ANTIBODIES, BISPECIFIC; ANTIGEN-ANTIBODY REACTIONS; ANTIGENS, DERMATOPHAGOIDES; BINDING SITES, ANTIBODY; CHEMISTRY, PHYSICAL; CHROMATOGRAPHY, GEL; GLYCOPROTEINS; HUMANS; IMMUNOGLOBULIN G; IMMUNOTHERAPY, ACTIVE; MITES;

EID: 0032792212     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.1999.00845.x     Document Type: Article

References (27)

1. 1. AALBERSE R.C., VAN DER GAAG R. & VAN LEEUWEN J. (1983) Serological aspects of IgG4 antibodies I. Prolonged immunization results in an IgG4-restricted response. J Immunol 130, 722.
2. 2. VAN DER ZEE J.S., VAN SWIETEN P. & AALBERSE R.C. (1986) Serological aspects of IgG4 antibodies. II. IgG4 antibodies form small, nonprecipitating immune complexes due to functional monovalency. J Immunol 137, 3566.
3. 3. BRUEGGEMANN M., WILLIAMS G.T., BINDON C.I. et al. (1987) Comparison of the effector functions of human immunoglobulins using a matched set of chimeric antibodies. J Exp Med 166, 1351.
4. 4. GREENWOOD J., CLARK M. & WALDMANN H. (1993) Structural motifs involved in human IgG antibody effector functions. Eur J Immunol 23, 1098.
5. 5. ISAACS J.D., CLARK M.R., GREENWOOD J. & WALDMANN H. (1992) Therapy with monoclonal antibodies. An in vivo model for the assessment of therapeutic potential. J Immunol 148, 3062.
6. 6. VAN DER ZEE J.S., VAN SWIETEN P. & AALBERSE R.C. (1986) Inhibition of complement activation by IgG4 antibodies. Clin Exp Immunol 64, 415.
7. 7. LAMBIN P., BOUZOUMOU A., MURRIETA M. et al. (1993) Purification of human IgG4 subclass with allergen-specific blocking activity. J Immunol Methods 165, 99.
8. 8. HAGAN P., BLUMENTHAL U.J., DUNN D., SIMPSON A.J.G. & WILKINS H.A. (1991) Human IgE, IgG4 and resistance to reinfection with Schistosoma haematobium. Nature 349, 243.
9. 9. KURNIAWAN A., YAZDANBAKIISH M., VAN REE R. et al. (1993) Differential expression of IgE and IgG4 specific antibody responses in asymptomatic and chronic human filariasis. J Immunol 150, 3941.
10. 10. RIHET P., DEMEURE C.F., DESSEIN A.J. & BOURGOIS A. (1992) Strong serum inhibition of specific IgE correlated to competing IgG4, revealed by a new methodology in subjects from a S. mansoni endemic area. Eur J Immunol 22, 2063.
11. 11. HUSSAIN R., POINDEXTER R.W. & OTTESKEN E.A. (1992) Control of allergic reactivity in human filariasis. J Immunol 148, 2731.
12. 12. VAN DER GIESSEN M., HOMAN W.L., VAN KERNEBEEK G., AALBERSE R.C. & DIEGES P.H. (1976) Subclass typing of IgG antibodies formed by grass pollen-allergic patients during immunotherapy. Int Arch Allergy Appl Immunol 50, 625.
13. 13. OEHLING A., SANZ M.L. & GARCIA B.E. (1992) Immunological parameters in the immunotherapy follow-up. Int Arch Allergy Immunol 99, 474.
14. 14. FULCHER C.A., DE GRAAF M. & ZIMMERMAN T.S. (1987) FVIII inhibitor IgG subclass and FVIII polypeptide specificity determined by immunoblotting. Blood 69, 1475.
15. 15. SCHUURMAN J., PERDOK G.J., MUELLER G.A. et al. (1997) Mouse/human chimeric IgG1 and IgG4 antibodies directed to the house dust mite allergen Der p 2: Use in quantification of allergen specific IgG. Clin Exp Allergy 27, 1095.
16. 16. OVSYANNIKOVA I.G., VAILES L.D., LI Y., HEYMANN P.W. & CHAPMAN M.D. (1994) Monoclonal antibodies to group II Dermatophagoides spp. allergens: murine immune response, epitope analysis, and development of a two-site ELISA. J Allergy Clin Immunol 94, 537.
17. 17. VAN DER ZEE J.S., VAN SWIETEN P., JANSEN H.M. & AALBERSE R.C. (1988) Skin tests and histamine release with P1-depleted D. pteronyssinus body extracts and purified P1. J Allergy Clin Immunol 81, 884.
18. 18. VAN REE R., CLEMENS J.C.J., AALBERS M., STAPEL S.O. & AALBERSE R.C. (1989) Characterization with monoclonal and polyclonal antibodies of a new major allergen from grass pollen in the group I molecular weight range. J Allergy Clin Immunol 83, 144.
19. 19. MUELLER G.A., SMITH A.M., WILLIAMS D.C. et al. (1997) Expression and secondary structure determination by NMR methods of the major house dust mite allergen Der p 2. J Biol Chem 272, 26893.
20. 20. PETERSEN J.G.L. & DORRINGTON K.J. (1974) An in vitro system for studying the kinetics of interchain disulphide bond formation in immunoglobulin G. J Biol Chem 249, 5633.
21. 21. KING D.J., ADAIR J.R., ANGAL S. et al. (1992) Expression, purification and characterization of a mouse-human chimeric antibody and chimeric Fab fragment. Biochem J 281, 317.
22. 22. COLCHER D., MILENIC D., ROSELLI M. et al. (1994) Characterization and biodistribution od recombinant/chimeric constructs of monoclonal antibody B72.3. Cancer Res 49, 1738.
23. 23. TURNER M.W., BENNICH H.H. & NATVIG J.B. (1970) Pepsin digestion of human G-myeloma proteins of different subclasses 11. Immunochemical investigations of the products of pepsin digestion. Clin Exp Immunol 7, 627.
24. 24. KABAT E.A., WU T.T., RED-MILLER M., PERRY H.M. & GOTTESMAN K.S. (1987) Sequences of proteins of immunological interest, edn 4. US Department of Health and Human Services. Public Health Service, National Institutes of Health.
25. 25. ANGAL S., KING D.J., BODMER M.W. et al. (1993) A single amino acid substitution abolishes the heterogeneity of chimeric mouse/human antibody. Mol Immunol 30, 105.
26. 26. PHILLIPS M.L., TAO M.H., MORRISON S.L. & SCHUMAKER V.N. (1994) Human/mouse chimeric monoclonal antibodies with human IgG1, IgG2, IgG3 and IgG4 constant domains: electron microscopic and hydrodynamic characterisation. Mol Immunol 31, 1201.
27. 27. AALBERSE R.C., DIEGES P.H., KNUL-BRETLOVA V., VOOREN P., AALBERS M. & VAN LEEUWEN J. (1983) IgG4 as blocking antibody. Clin Rev Allerg 1, 289.