Production of TNF-α in macrophages activated by T cells, compared with lipopolysaccharide, uses distinct IL-10-dependent regulatory mechanism

Journal of Immunology

Volumn 188, Issue 3, 2012, Pages 1307-1317

  Agbanoma, Gideon ^a   Li, Ching ^a   Ennis, Darren ^a,b   Palfreeman, Andrew C ^a   Williams, Lynn M ^a   Brennan, Fionula M ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; LIPOPOLYSACCHARIDE; STAT3 PROTEIN; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA;

3' UNTRANSLATED REGION; ARTICLE; COCULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN TISSUE; MACROPHAGE ACTIVATION; PRIORITY JOURNAL; REGULATORY MECHANISM; RHEUMATOID ARTHRITIS; SYNOVIUM; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TUMOR NECROSIS FACTOR ALPHA GENE;

ARTHRITIS, RHEUMATOID; HUMANS; INFLAMMATION; INTERLEUKIN-10; LIPOPOLYSACCHARIDES; LYMPHOCYTE ACTIVATION; MACROPHAGES; T-LYMPHOCYTES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84863045976     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1100625     Document Type: Article

References (33)

1. Brennan, F. M., D. Chantry, A. Jackson, R. Maini, and M. Feldmann. 1989. Inhibitory effect of TNF alpha antibodies on synovial cell interleukin-1 production in rheumatoid arthritis. Lancet 2: 244-247. (Pubitemid 19180612)
2. Brennan, F. M., D. Chantry, A. M. Jackson, R. N. Maini, and M. Feldmann. 1989. Cytokine production in culture by cells isolated from the synovial membrane. J. Autoimmun. 2: 177-186.
3. Butler, D. M., R. N. Maini, M. Feldmann, and F. M. Brennan. 1995. Modulation of proinflammatory cytokine release in rheumatoid synovial membrane cell cultures: comparison of monoclonal anti-TNF-alpha antibody with the interleukin-1 receptor antagonist. Eur. Cytokine Netw. 6: 225-230. (Pubitemid 26018294)
4. Elliott, M. J., R. N. Maini, M. Feldmann, A. Long-Fox, P. Charles, P. Katsikis, F. M. Brennan, J. Walker, H. Bijl, J. Ghrayeb, et al. 1993. Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor alpha. Arthritis Rheum. 36: 1681-1690. (Pubitemid 23360007)
5. Elliott, M. J., R. N. Maini, M. Feldmann, J. R. Kalden, C. Antoni, J. S. Smolen, B. Leeb, F. C. Breedveld, J. D. Macfarlane, H. Bijl, et al. 1994. Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor alpha (cA2) versus placebo in rheumatoid arthritis. Lancet 344: 1105-1110. (Pubitemid 24317629)
6. Rankin, E. C., E. H. Choy, D. Kassimos, G. H. Kingsley, A. M. Sopwith, D. A. Isenberg, and G. S. Panayi. 1995. The therapeutic effects of an engineered human anti-tumour necrosis factor alpha antibody (CDP571) in rheumatoid arthritis. Br. J. Rheumatol. 34: 334-342.
7. Moreland, L. W., S. W. Baumgartner, M. H. Schiff, E. A. Tindall, R. M. Fleischmann, A. L. Weaver, R. E. Ettlinger, S. Cohen, W. J. Koopman, K. Mohler, et al. 1997. Treatment of rheumatoid arthritis with a recombinant human tumor necrosis factor receptor (p75)-Fc fusion protein. N. Engl. J. Med. 337: 141-147. (Pubitemid 27306284)
8. Feldmann, M., M. J. Elliott, J. N. Woody, and R. N. Maini. 1997. Anti-tumor necrosis factor-alpha therapy of rheumatoid arthritis. Adv. Immunol. 64: 283-350. (Pubitemid 27161392)
9. Maini, R. N., F. C. Breedveld, J. R. Kalden, J. S. Smolen, D. Davis, J. D. Macfarlane, C. Antoni, B. Leeb, M. J. Elliott, J. N. Woody, et al. 1998. Therapeutic efficacy of multiple intravenous infusions of anti-tumor necrosis factor alpha monoclonal antibody combined with low-dose weekly methotrexate in rheumatoid arthritis. Arthritis Rheum. 41: 1552-1563. (Pubitemid 28459913)
10. Maini, R. N., P. C. Taylor, E. Paleolog, P. Charles, S. Ballara, F. M. Brennan, and M. Feldmann. 1999. Anti-tumour necrosis factor specific antibody (infliximab) treatment provides insights into the pathophysiology of rheumatoid arthritis. Ann. Rheum. Dis. 58(Suppl. 1): I56-I60.
11. Krausgruber, T., D. Saliba, G. Ryzhakov, A. Lanfrancotti, K. Blazek, and I. A. Udalova. 2010. IRF5 is required for late-phase TNF secretion by human dendritic cells. Blood 115: 4421-4430.
12. Brennan, F. M., A. L. Hayes, C. J. Ciesielski, P. Green, B. M. Foxwell, and M. Feldmann. 2002. Evidence that rheumatoid arthritis synovial T cells are similar to cytokine-activated T cells: involvement of phosphatidylinositol 3-kinase and nuclear factor kappaB pathways in tumor necrosis factor alpha production in rheumatoid arthritis. Arthritis Rheum. 46: 31-41. (Pubitemid 34121648)
13. Benito, M. J., E. Murphy, E. P. Murphy, W. B. van den Berg, O. FitzGerald, and B. Bresnihan. 2004. Increased synovial tissue NF-kappa B1 expression at sites adjacent to the cartilage-pannus junction in rheumatoid arthritis. Arthritis Rheum. 50: 1781-1787. (Pubitemid 38725090)
14. Danning, C. L., G. G. Illei, C. Hitchon, M. R. Greer, D. T. Boumpas, and I. B. McInnes. 2000. Macrophage-derived cytokine and nuclear factor kappaB p65 expression in synovial membrane and skin of patients with psoriatic arthritis. Arthritis Rheum. 43: 1244-1256. (Pubitemid 30416309)
15. Tsao, P. W., T. Suzuki, R. Totsuka, T. Murata, T. Takagi, Y. Ohmachi, H. Fujimura, and I. Takata. 1997. The effect of dexamethasone on the expression of activated NF-kappa B in adjuvant arthritis. Clin. Immunol. Immunopathol. 83: 173-178. (Pubitemid 27195937)
16. Brennan, F. M., A. D. Foey, and M. Feldmann. 2006. The importance of T cell interactions with macrophages in rheumatoid cytokine production. Curr. Top. Microbiol. Immunol. 305: 177-194. (Pubitemid 47400270)
17. Katsikis, P. D., C. Q. Chu, F. M. Brennan, R. N. Maini, and M. Feldmann. 1994. Immunoregulatory role of interleukin 10 in rheumatoid arthritis. J. Exp. Med. 179: 1517-1527. (Pubitemid 24129569)
18. Antoniv, T. T., and L. B. Ivashkiv. 2006. Dysregulation of interleukin-10-dependent gene expression in rheumatoid arthritis synovial macrophages. Arthritis Rheum. 54: 2711-2721. (Pubitemid 44497750)
19. Brennan, F. M., N. M. Smith, S. Owen, C. Li, P. Amjadi, P. Green, A. Andersson, A. C. Palfreeman, P. Hillyer, A. Foey, et al. 2008. Resting CD4+ effector memory T cells are precursors of bystander-activated effectors: a surrogate model of rheumatoid arthritis synovial T-cell function. Arthritis Res. Ther. 10: R36.
20. Campbell, J., C. J. Ciesielski, A. E. Hunt, N. J. Horwood, J. T. Beech, L. A. Hayes, A. Denys, M. Feldmann, F. M. Brennan, and B. M. Foxwell. 2004. A novel mechanism for TNF-alpha regulation by p38 MAPK: involvement of NF-kappa B with implications for therapy in rheumatoid arthritis. J. Immunol. 173: 6928-6937. (Pubitemid 39541081)
21. El Kasmi, K. C., A. M. Smith, L. Williams, G. Neale, A. D. Panopoulos, S. S. Watowich, H. Häcker, B. M. Foxwell, and P. J. Murray. 2007. Cutting edge: a transcriptional repressor and corepressor induced by the STAT3-regulated antiinflammatory signaling pathway. J. Immunol. 179: 7215-7219.
22. Denys, A., I. A. Udalova, C. Smith, L. M. Williams, C. J. Ciesielski, J. Campbell, C. Andrews, D. Kwaitkowski, and B. M. Foxwell. 2002. Evidence for a dual mechanism for IL-10 suppression of TNF-alpha production that does not involve inhibition of p38 mitogen-activated protein kinase or NF-kappa B in primary human macrophages. J. Immunol. 168: 4837-4845. (Pubitemid 34495944)
23. de Waal Malefyt, R., J. Abrams, B. Bennett, C. G. Figdor, and J. E. de Vries. 1991. Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J. Exp. Med. 174: 1209-1220.
24. Kuprash, D. V., I. A. Udalova, R. L. Turetskaya, N. R. Rice, and S. A. Nedospasov. 1995. Conserved kappa B element located downstream of the tumor necrosis factor alpha gene: distinct NF-kappa B binding pattern and enhancer activity in LPS activated murine macrophages. Oncogene 11: 97-106.
25. Smallie, T., G. Ricchetti, N. J. Horwood, M. Feldmann, A. R. Clark, and L. M. Williams. 2010. IL-10 inhibits transcription elongation of the human TNF gene in primary macrophages. J. Exp. Med. 207: 2081-2088.
26. Murray, P. J. 2006. Understanding and exploiting the endogenous interleukin-10/STAT3-mediated anti-inflammatory response. Curr. Opin. Pharmacol. 6: 379-386.
27. Williams, L. M., G. Ricchetti, U. Sarma, T. Smallie, and B. M. Foxwell. 2004. Interleukin-10 suppression of myeloid cell activation: a continuing puzzle. Immunology 113: 281-292. (Pubitemid 39472144)
28. Pestka, S., C. D. Krause, D. Sarkar, M. R. Walter, Y. Shi, and P. B. Fisher. 2004. Interleukin-10 and related cytokines and receptors. Annu. Rev. Immunol. 22: 929-979. (Pubitemid 38680445)
29. Williams, L. M., U. Sarma, K. Willets, T. Smallie, F. M. Brennan, and B. M. J. Foxwell. 2007. Expression of constitutively active STAT3 can replicate the cytokine-suppressive activity of interleukin-10 in human primary macrophages. J. Biol. Chem. 282: 6965-6975. (Pubitemid 47093676)
30. Riley, J. K., K. Takeda, S. Akira, and R. D. Schreiber. 1999. Interleukin-10 receptor signaling through the JAK-STAT pathway: requirement for two distinct receptor-derived signals for anti-inflammatory action. J. Biol. Chem. 274: 16513-16521.
31. Crawley, J. B., L. M. Williams, T. Mander, F. M. Brennan, and B. M. Foxwell. 1996. Interleukin-10 stimulation of phosphatidylinositol 3-kinase and p70 S6 kinase is required for the proliferative but not the antiinflammatory effects of the cytokine. J. Biochem. Chem. 271: 16357-16362. (Pubitemid 26236260)
32. Beech, J. T., E. Andreakos, C. J. Ciesielski, P. Green, B. M. Foxwell, and F. M. Brennan. 2006. T-cell contact-dependent regulation of CC and CXC chemokine production in monocytes through differential involvement of NFkappaB: implications for rheumatoid arthritis. Arthritis Res. Ther. 8: R168.
33. Herrero, C., X. Hu, W. P. Li, S. Samuels, M. N. Sharif, S. Kotenko, and L. B. Ivashkiv. 2003. Reprogramming of IL-10 activity and signaling by IFN-gamma. J. Immunol. 171: 5034-5041. (Pubitemid 37432784)