-
1
-
-
0033149863
-
Pathogenesis of autoimmune hepatitis
-
McFarlane IG, (1999) Pathogenesis of autoimmune hepatitis. Biomed Pharmacother 53: 255-263.
-
(1999)
Biomed Pharmacother
, vol.53
, pp. 255-263
-
-
McFarlane, I.G.1
-
2
-
-
0037967918
-
Liver NKT cells: an account of heterogeneity
-
Emoto M, Kaufmann SH, (2003) Liver NKT cells: an account of heterogeneity. Trends Immunol 24: 364-369.
-
(2003)
Trends Immunol
, vol.24
, pp. 364-369
-
-
Emoto, M.1
Kaufmann, S.H.2
-
3
-
-
0034058378
-
Leptin-deficient (ob/ob) mice are protected from T cell-mediated hepatotoxicity: role of tumor necrosis factor alpha and IL-18
-
Faggioni R, Jones-Carson J, Reed DA, Dinarello CA, Feingold KR, et al. (2000) Leptin-deficient (ob/ob) mice are protected from T cell-mediated hepatotoxicity: role of tumor necrosis factor alpha and IL-18. Proc Natl Acad Sci U S A 97: 2367-2372.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 2367-2372
-
-
Faggioni, R.1
Jones-Carson, J.2
Reed, D.A.3
Dinarello, C.A.4
Feingold, K.R.5
-
4
-
-
0028795171
-
Concanavalin A-induced T-cell-mediated hepatic injury in mice: the role of tumor necrosis factor
-
Gantner F, Leist M, Lohse AW, Germann PG, Tiegs G, (1995) Concanavalin A-induced T-cell-mediated hepatic injury in mice: the role of tumor necrosis factor. Hepatology 21: 190-198.
-
(1995)
Hepatology
, vol.21
, pp. 190-198
-
-
Gantner, F.1
Leist, M.2
Lohse, A.W.3
Germann, P.G.4
Tiegs, G.5
-
5
-
-
0028999453
-
Tumor necrosis factor-induced hepatocyte apoptosis precedes liver failure in experimental murine shock models
-
Leist M, Gantner F, Bohlinger I, Tiegs G, Germann PG, et al. (1995) Tumor necrosis factor-induced hepatocyte apoptosis precedes liver failure in experimental murine shock models. Am J Pathol 146: 1220-1234.
-
(1995)
Am J Pathol
, vol.146
, pp. 1220-1234
-
-
Leist, M.1
Gantner, F.2
Bohlinger, I.3
Tiegs, G.4
Germann, P.G.5
-
6
-
-
0035424975
-
CD1-specific T cells in microbial immunity
-
Gumperz JE, Brenner MB, (2001) CD1-specific T cells in microbial immunity. Curr Opin Immunol 13: 471-478.
-
(2001)
Curr Opin Immunol
, vol.13
, pp. 471-478
-
-
Gumperz, J.E.1
Brenner, M.B.2
-
7
-
-
0033662145
-
NKT cells: facts, functions and fallacies
-
Godfrey DI, Hammond KJ, Poulton LD, Smyth MJ, Baxter AG, (2000) NKT cells: facts, functions and fallacies. Immunol Today 21: 573-583.
-
(2000)
Immunol Today
, vol.21
, pp. 573-583
-
-
Godfrey, D.I.1
Hammond, K.J.2
Poulton, L.D.3
Smyth, M.J.4
Baxter, A.G.5
-
8
-
-
0032587098
-
The roles of intrahepatic Valpha14(+) NK1.1(+) T cells for liver injury induced by Salmonella infection in mice
-
Ishigami M, Nishimura H, Naiki Y, Yoshioka K, Kawano T, et al. (1999) The roles of intrahepatic Valpha14(+) NK1.1(+) T cells for liver injury induced by Salmonella infection in mice. Hepatology 29: 1799-1808.
-
(1999)
Hepatology
, vol.29
, pp. 1799-1808
-
-
Ishigami, M.1
Nishimura, H.2
Naiki, Y.3
Yoshioka, K.4
Kawano, T.5
-
9
-
-
0034598156
-
Augmentation of Valpha14 NKT cell-mediated cytotoxicity by interleukin 4 in an autocrine mechanism resulting in the development of concanavalin A-induced hepatitis
-
Kaneko Y, Harada M, Kawano T, Yamashita M, Shibata Y, et al. (2000) Augmentation of Valpha14 NKT cell-mediated cytotoxicity by interleukin 4 in an autocrine mechanism resulting in the development of concanavalin A-induced hepatitis. J Exp Med 191: 105-114.
-
(2000)
J Exp Med
, vol.191
, pp. 105-114
-
-
Kaneko, Y.1
Harada, M.2
Kawano, T.3
Yamashita, M.4
Shibata, Y.5
-
10
-
-
0033869941
-
Regulation of liver inflammatory injury by signal transducer and activator of transcription-6
-
Kato A, Yoshidome H, Edwards MJ, Lentsch AB, (2000) Regulation of liver inflammatory injury by signal transducer and activator of transcription-6. Am J Pathol 157: 297-302.
-
(2000)
Am J Pathol
, vol.157
, pp. 297-302
-
-
Kato, A.1
Yoshidome, H.2
Edwards, M.J.3
Lentsch, A.B.4
-
11
-
-
0032698211
-
Antitumor cytotoxicity mediated by ligand-activated human V alpha24 NKT cells
-
Kawano T, Nakayama T, Kamada N, Kaneko Y, Harada M, et al. (1999) Antitumor cytotoxicity mediated by ligand-activated human V alpha24 NKT cells. Cancer Res 59: 5102-5105.
-
(1999)
Cancer Res
, vol.59
, pp. 5102-5105
-
-
Kawano, T.1
Nakayama, T.2
Kamada, N.3
Kaneko, Y.4
Harada, M.5
-
12
-
-
0036838607
-
Distinct subsets of human Valpha24-invariant NKT cells: cytokine responses and chemokine receptor expression
-
Kim CH, Butcher EC, Johnston B, (2002) Distinct subsets of human Valpha24-invariant NKT cells: cytokine responses and chemokine receptor expression. Trends Immunol 23: 516-519.
-
(2002)
Trends Immunol
, vol.23
, pp. 516-519
-
-
Kim, C.H.1
Butcher, E.C.2
Johnston, B.3
-
13
-
-
0026643743
-
A T cell-dependent experimental liver injury in mice inducible by concanavalin A
-
Tiegs G, Hentschel J, Wendel A, (1992) A T cell-dependent experimental liver injury in mice inducible by concanavalin A. J Clin Invest 90: 196-203.
-
(1992)
J Clin Invest
, vol.90
, pp. 196-203
-
-
Tiegs, G.1
Hentschel, J.2
Wendel, A.3
-
14
-
-
0028863822
-
Positive selection of mouse NK1+ T cells by CD1-expressing cortical thymocytes
-
Bendelac A, (1995) Positive selection of mouse NK1+ T cells by CD1-expressing cortical thymocytes. J Exp Med 182: 2091-2096.
-
(1995)
J Exp Med
, vol.182
, pp. 2091-2096
-
-
Bendelac, A.1
-
16
-
-
0141958207
-
Glycolipid antigen drives rapid expansion and sustained cytokine production by NK T cells
-
Crowe NY, Uldrich AP, Kyparissoudis K, Hammond KJ, Hayakawa Y, et al. (2003) Glycolipid antigen drives rapid expansion and sustained cytokine production by NK T cells. J Immunol 171: 4020-4027.
-
(2003)
J Immunol
, vol.171
, pp. 4020-4027
-
-
Crowe, N.Y.1
Uldrich, A.P.2
Kyparissoudis, K.3
Hammond, K.J.4
Hayakawa, Y.5
-
17
-
-
0038544245
-
Differential requirement for Rel/nuclear factor kappa B family members in natural killer T cell development
-
Sivakumar V, Hammond KJ, Howells N, Pfeffer K, Weih F, (2003) Differential requirement for Rel/nuclear factor kappa B family members in natural killer T cell development. J Exp Med 197: 1613-1621.
-
(2003)
J Exp Med
, vol.197
, pp. 1613-1621
-
-
Sivakumar, V.1
Hammond, K.J.2
Howells, N.3
Pfeffer, K.4
Weih, F.5
-
18
-
-
0033625869
-
Protein kinase Ctheta: a new essential superstar on the T-cell stage
-
Altman A, Isakov N, Baier G, (2000) Protein kinase Ctheta: a new essential superstar on the T-cell stage. Immunol Today 21: 567-573.
-
(2000)
Immunol Today
, vol.21
, pp. 567-573
-
-
Altman, A.1
Isakov, N.2
Baier, G.3
-
19
-
-
0038620475
-
Protein kinase C theta affects Ca2+ mobilization and NFAT cell activation in primary mouse T cells
-
Pfeifhofer C, Kofler K, Gruber T, Tabrizi NG, Lutz C, et al. (2003) Protein kinase C theta affects Ca2+ mobilization and NFAT cell activation in primary mouse T cells. J Exp Med 197: 1525-1535.
-
(2003)
J Exp Med
, vol.197
, pp. 1525-1535
-
-
Pfeifhofer, C.1
Kofler, K.2
Gruber, T.3
Tabrizi, N.G.4
Lutz, C.5
-
20
-
-
18844473151
-
PKC-theta is required for TCR-induced NF-kappaB activation in mature but not immature T lymphocytes
-
Sun Z, Arendt CW, Ellmeier W, Schaeffer EM, Sunshine MJ, et al. (2000) PKC-theta is required for TCR-induced NF-kappaB activation in mature but not immature T lymphocytes. Nature 404: 402-407.
-
(2000)
Nature
, vol.404
, pp. 402-407
-
-
Sun, Z.1
Arendt, C.W.2
Ellmeier, W.3
Schaeffer, E.M.4
Sunshine, M.J.5
-
21
-
-
0028014460
-
Signal transduction by lymphocyte antigen receptors
-
Weiss A, Littman DR, (1994) Signal transduction by lymphocyte antigen receptors. Cell 76: 263-274.
-
(1994)
Cell
, vol.76
, pp. 263-274
-
-
Weiss, A.1
Littman, D.R.2
-
22
-
-
0029670089
-
Protein kinase C-theta isoenzyme selective stimulation of the transcription factor complex AP-1 in T lymphocytes
-
Baier-Bitterlich G, Uberall F, Bauer B, Fresser F, Wachter H, et al. (1996) Protein kinase C-theta isoenzyme selective stimulation of the transcription factor complex AP-1 in T lymphocytes. Mol Cell Biol 16: 1842-1850.
-
(1996)
Mol Cell Biol
, vol.16
, pp. 1842-1850
-
-
Baier-Bitterlich, G.1
Uberall, F.2
Bauer, B.3
Fresser, F.4
Wachter, H.5
-
23
-
-
0034724201
-
NF-kappa B activation induced by T cell receptor/CD28 costimulation is mediated by protein kinase C-theta
-
Coudronniere N, Villalba M, Englund N, Altman A, (2000) NF-kappa B activation induced by T cell receptor/CD28 costimulation is mediated by protein kinase C-theta. Proc Natl Acad Sci U S A 97: 3394-3399.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 3394-3399
-
-
Coudronniere, N.1
Villalba, M.2
Englund, N.3
Altman, A.4
-
24
-
-
0034031401
-
Protein kinase C-theta participates in NF-kappaB activation induced by CD3-CD28 costimulation through selective activation of IkappaB kinase beta
-
Lin X, O'Mahony A, Mu Y, Geleziunas R, Greene WC, (2000) Protein kinase C-theta participates in NF-kappaB activation induced by CD3-CD28 costimulation through selective activation of IkappaB kinase beta. Mol Cell Biol 20: 2933-2940.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 2933-2940
-
-
Lin, X.1
O'Mahony, A.2
Mu, Y.3
Geleziunas, R.4
Greene, W.C.5
-
25
-
-
1842524184
-
SPAK kinase is a substrate and target of PKCtheta in T-cell receptor-induced AP-1 activation pathway
-
Li Y, Hu J, Vita R, Sun B, Tabata H, et al. (2004) SPAK kinase is a substrate and target of PKCtheta in T-cell receptor-induced AP-1 activation pathway. EMBO J 23: 1112-1122.
-
(2004)
EMBO J
, vol.23
, pp. 1112-1122
-
-
Li, Y.1
Hu, J.2
Vita, R.3
Sun, B.4
Tabata, H.5
-
26
-
-
0038701681
-
The PKC gene module: molecular biosystematics to resolve its T cell functions
-
Baier G, (2003) The PKC gene module: molecular biosystematics to resolve its T cell functions. Immunol Rev 192: 64-79.
-
(2003)
Immunol Rev
, vol.192
, pp. 64-79
-
-
Baier, G.1
-
27
-
-
79954507884
-
PKC-theta is a drug target for prevention of T cell-mediated autoimmunity and allograft rejection
-
Kwon MJ, Wang R, Ma J, Sun Z, (2010) PKC-theta is a drug target for prevention of T cell-mediated autoimmunity and allograft rejection. Endocr Metab Immune Disord Drug Targets 10: 367-372.
-
(2010)
Endocr Metab Immune Disord Drug Targets
, vol.10
, pp. 367-372
-
-
Kwon, M.J.1
Wang, R.2
Ma, J.3
Sun, Z.4
-
28
-
-
77956310634
-
Efficient Isolation of Mouse Liver NKT Cells by Perfusion
-
Fang X, Du P, Liu Y, Tang J, (2010) Efficient Isolation of Mouse Liver NKT Cells by Perfusion. PLoS ONE 5: e10288.
-
(2010)
PLoS ONE
, vol.5
-
-
Fang, X.1
Du, P.2
Liu, Y.3
Tang, J.4
-
29
-
-
44449137653
-
Assessment of lymphocyte development in radiation bone marrow chimeras
-
Unit 4 6
-
Spangrude GJ, (2008) Assessment of lymphocyte development in radiation bone marrow chimeras. Curr Protoc Immunol Chapter 4: Unit 4 6.
-
(2008)
Curr Protoc Immunol Chapter
, vol.4
-
-
Spangrude, G.J.1
-
30
-
-
38149084701
-
Methods for detection, isolation and culture of mouse and human invariant NKT cells
-
Watarai H, Nakagawa R, Omori-Miyake M, Dashtsoodol N, Taniguchi M, (2008) Methods for detection, isolation and culture of mouse and human invariant NKT cells. Nat Protocols 3: 70-78.
-
(2008)
Nat Protocols
, vol.3
, pp. 70-78
-
-
Watarai, H.1
Nakagawa, R.2
Omori-Miyake, M.3
Dashtsoodol, N.4
Taniguchi, M.5
-
31
-
-
0033936909
-
Essential pathogenetic role for interferon (IFN-)gamma in concanavalin A-induced T cell-dependent hepatitis: exacerbation by exogenous IFN-gamma and prevention by IFN-gamma receptor-immunoglobulin fusion protein
-
Nicoletti F, Zaccone P, Xiang M, Magro G, Di Mauro M, et al. (2000) Essential pathogenetic role for interferon (IFN-)gamma in concanavalin A-induced T cell-dependent hepatitis: exacerbation by exogenous IFN-gamma and prevention by IFN-gamma receptor-immunoglobulin fusion protein. Cytokine 12: 315-323.
-
(2000)
Cytokine
, vol.12
, pp. 315-323
-
-
Nicoletti, F.1
Zaccone, P.2
Xiang, M.3
Magro, G.4
Di Mauro, M.5
-
32
-
-
0028025320
-
Kinetics of tumour necrosis factor-alpha, soluble tumour necrosis factor receptors, interleukin 1-beta and its receptor antagonist during serious infections
-
van Deuren M, (1994) Kinetics of tumour necrosis factor-alpha, soluble tumour necrosis factor receptors, interleukin 1-beta and its receptor antagonist during serious infections. Eur J Clin Microbiol Infect Dis 13 (Suppl 1): S12-16.
-
(1994)
Eur J Clin Microbiol Infect Dis
, vol.13
, Issue.SUPPL. 1
-
-
van Deuren, M.1
-
33
-
-
42149085600
-
Pathophysiological role of osteopontin in hepatic inflammation, toxicity, and cancer
-
Ramaiah SK, Rittling S, (2008) Pathophysiological role of osteopontin in hepatic inflammation, toxicity, and cancer. Toxicol Sci 103: 4-13.
-
(2008)
Toxicol Sci
, vol.103
, pp. 4-13
-
-
Ramaiah, S.K.1
Rittling, S.2
-
34
-
-
51349121407
-
The transcription factor PLZF directs the effector program of the NKT cell lineage
-
Savage AK, Constantinides MG, Han J, Picard D, Martin E, et al. (2008) The transcription factor PLZF directs the effector program of the NKT cell lineage. Immunity 29: 391-403.
-
(2008)
Immunity
, vol.29
, pp. 391-403
-
-
Savage, A.K.1
Constantinides, M.G.2
Han, J.3
Picard, D.4
Martin, E.5
-
35
-
-
0346422479
-
Bile acids up-regulate death receptor 5/TRAIL-receptor 2 expression via a c-Jun N-terminal kinase-dependent pathway involving Sp1
-
Higuchi H, Grambihler A, Canbay A, Bronk SF, Gores GJ, (2004) Bile acids up-regulate death receptor 5/TRAIL-receptor 2 expression via a c-Jun N-terminal kinase-dependent pathway involving Sp1. J Biol Chem 279: 51-60.
-
(2004)
J Biol Chem
, vol.279
, pp. 51-60
-
-
Higuchi, H.1
Grambihler, A.2
Canbay, A.3
Bronk, S.F.4
Gores, G.J.5
-
36
-
-
34547193134
-
Free fatty acids sensitise hepatocytes to TRAIL mediated cytotoxicity
-
Malhi H, Barreyro FJ, Isomoto H, Bronk SF, Gores GJ, (2007) Free fatty acids sensitise hepatocytes to TRAIL mediated cytotoxicity. Gut 56: 1124-1131.
-
(2007)
Gut
, vol.56
, pp. 1124-1131
-
-
Malhi, H.1
Barreyro, F.J.2
Isomoto, H.3
Bronk, S.F.4
Gores, G.J.5
-
37
-
-
7044272844
-
To be or not to be NKT: natural killer T cells in the liver
-
Exley MA, Koziel MJ, (2004) To be or not to be NKT: natural killer T cells in the liver. Hepatology 40: 1033-1040.
-
(2004)
Hepatology
, vol.40
, pp. 1033-1040
-
-
Exley, M.A.1
Koziel, M.J.2
-
38
-
-
36749057429
-
Structure-based optimization of PKCtheta inhibitors
-
Mosyak L, Xu Z, Joseph-McCarthy D, Brooijmans N, Somers W, et al. (2007) Structure-based optimization of PKCtheta inhibitors. Biochem Soc Trans 35: 1027-1031.
-
(2007)
Biochem Soc Trans
, vol.35
, pp. 1027-1031
-
-
Mosyak, L.1
Xu, Z.2
Joseph-McCarthy, D.3
Brooijmans, N.4
Somers, W.5
-
39
-
-
33845671162
-
Discovery of potent and selective PKC-theta inhibitors
-
Cywin CL, Dahmann G, Prokopowicz AS 3rd, Young ER, Magolda RL, et al. (2007) Discovery of potent and selective PKC-theta inhibitors. Bioorg Med Chem Lett 17: 225-230.
-
(2007)
Bioorg Med Chem Lett
, vol.17
, pp. 225-230
-
-
Cywin, C.L.1
Dahmann, G.2
Prokopowicz 3rd, A.S.3
Young, E.R.4
Magolda, R.L.5
-
40
-
-
1842424840
-
Cutting edge: the ontogeny and function of Va14Ja18 natural T lymphocytes require signal processing by protein kinase C theta and NF-kappa B
-
Stanic AK, Bezbradica JS, Park JJ, Van Kaer L, Boothby MR, et al. (2004) Cutting edge: the ontogeny and function of Va14Ja18 natural T lymphocytes require signal processing by protein kinase C theta and NF-kappa B. J Immunol 172: 4667-4671.
-
(2004)
J Immunol
, vol.172
, pp. 4667-4671
-
-
Stanic, A.K.1
Bezbradica, J.S.2
Park, J.J.3
van Kaer, L.4
Boothby, M.R.5
-
41
-
-
1842480966
-
Differential dependence of CD4+CD25+ regulatory and natural killer-like T cells on signals leading to NF-kappaB activation
-
Schmidt-Supprian M, Tian J, Grant EP, Pasparakis M, Maehr R, et al. (2004) Differential dependence of CD4+CD25+ regulatory and natural killer-like T cells on signals leading to NF-kappaB activation. Proc Natl Acad Sci U S A 101: 4566-4571.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 4566-4571
-
-
Schmidt-Supprian, M.1
Tian, J.2
Grant, E.P.3
Pasparakis, M.4
Maehr, R.5
-
43
-
-
0031201232
-
Requirement of IL-4 and liver NK1+ T cells for concanavalin A-induced hepatic injury in mice
-
Toyabe S, Seki S, Iiai T, Takeda K, Shirai K, et al. (1997) Requirement of IL-4 and liver NK1+ T cells for concanavalin A-induced hepatic injury in mice. J Immunol 159: 1537-1542.
-
(1997)
J Immunol
, vol.159
, pp. 1537-1542
-
-
Toyabe, S.1
Seki, S.2
Iiai, T.3
Takeda, K.4
Shirai, K.5
-
44
-
-
5644276291
-
Osteopontin as a mediator of NKT cell function in T cell-mediated liver diseases
-
Diao H, Kon S, Iwabuchi K, Kimura C, Morimoto J, et al. (2004) Osteopontin as a mediator of NKT cell function in T cell-mediated liver diseases. Immunity 21: 539-550.
-
(2004)
Immunity
, vol.21
, pp. 539-550
-
-
Diao, H.1
Kon, S.2
Iwabuchi, K.3
Kimura, C.4
Morimoto, J.5
-
45
-
-
33845921462
-
The critical role of protein kinase C-theta in Fas/Fas ligand-mediated apoptosis
-
Manicassamy S, Sun Z, (2007) The critical role of protein kinase C-theta in Fas/Fas ligand-mediated apoptosis. J Immunol 178: 312-319.
-
(2007)
J Immunol
, vol.178
, pp. 312-319
-
-
Manicassamy, S.1
Sun, Z.2
-
46
-
-
0031671739
-
Immune phenotype of chronic liver disease
-
Czaja AJ, dos Santos RM, Porto A, Santrach PJ, Moore SB, (1998) Immune phenotype of chronic liver disease. Dig Dis Sci 43: 2149-2155.
-
(1998)
Dig Dis Sci
, vol.43
, pp. 2149-2155
-
-
Czaja, A.J.1
dos Santos, R.M.2
Porto, A.3
Santrach, P.J.4
Moore, S.B.5
-
47
-
-
0036322130
-
Diagnosis and treatment of autoimmune hepatitis
-
Czaja AJ, Freese DK, (2002) Diagnosis and treatment of autoimmune hepatitis. Hepatology 36: 479-497.
-
(2002)
Hepatology
, vol.36
, pp. 479-497
-
-
Czaja, A.J.1
Freese, D.K.2
|