Structure-based optimization of PKCθ inhibitors

Biochemical Society Transactions

Volumn 35, Issue 5, 2007, Pages 1027-1031

  Mosyak, L ^a   Xu, Z ^a   Joseph McCarthy, D ^a   Brooijmans, N ^a   Somers, W ^a   Chaudhary, D ^a  

^a PFIZER INC   (United States)

Author keywords

ATP competitive kinase inhibitor; Molecular modelling; Protein kinase C (PKC); Protein kinase C inhibitor; Structure based optimization; T cell

Indexed keywords

B LYMPHOCYTE RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE C INHIBITOR; PROTEIN KINASE C THETA; PROTEIN TYROSINE KINASE; TUMOR NECROSIS FACTOR;

AUTOPHOSPHORYLATION; CONFERENCE PAPER; CRYSTALLIZATION; HUMAN; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; PROTEIN MODIFICATION; PROTEIN STRUCTURE; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ISOENZYMES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN KINASE C; PROTEIN KINASE INHIBITORS; SUBSTRATE SPECIFICITY;

EID: 36749057429     PISSN: 03005127     EISSN: None     Source Type: Journal    
DOI: 10.1042/BST0351027     Document Type: Conference Paper

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