Using a functional enzyme model to understand the chemistry behind hydrogen sulfide induced hibernation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 52, 2009, Pages 22090-22095

  Collman, James P ^a   Ghosh, Somdatta ^a   Dey, Abhishek ^a   Decréau, Richard A ^a  

^a STANFORD UNIVERSITY   (United States)

Author keywords

Cytochrome c oxidase; H2S complex; Reversible inhibition; Synthetic functional model

Indexed keywords

COPPER; CYTOCHROME C OXIDASE; HEME; HYDROGEN SULFIDE; IRON; OXYGEN; PORPHYRIN DERIVATIVE;

ARTICLE; BIOLOGICAL ACTIVITY; BREATHING; CATALYSIS; CONCENTRATION (PARAMETERS); ELECTRON; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME INHIBITION; ENZYME METABOLISM; FOOD; HIBERNATION; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN FUNCTION; SPECTROSCOPY;

ANIMALS; CATALYTIC DOMAIN; ELECTROCHEMISTRY; ELECTRON SPIN RESONANCE SPECTROSCOPY; ELECTRON TRANSPORT COMPLEX IV; HIBERNATION; HYDROGEN SULFIDE; IRON; MODELS, BIOLOGICAL; MODELS, MOLECULAR; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; SPECTROSCOPY, FOURIER TRANSFORM INFRARED;

EID: 76049087222     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0904082106     Document Type: Article

References (39)

1. Collman JP, Gagne RR, Reed CA (1974) A paramagnetic dioxygen complex of iron II derived from a picket fence porphyrin further models for hemoproteins. J Am Chem Soc 96:2629-2631.
2. Collman JP, Gagne RR, Halbert TR, Marchon JC, Reed CA (1973) Reversible oxygen adduct formation in ferrous complexes derived from a picket fence porphyrin model for oxy myoglobin. J Am Chem Soc 95:7868-7870.
3. Collman JP, Brauman JI, Rose E, Suslick KS (1978) Cooperativity in O2 binding to iron porphyrins. Proc Natl Acad Sci USA 75:1052-1055.
4. Collman JP, et al. (1975) Picket-Fence Porphyrins. Synthetic Models for Oxygen Binding Hemoproteins. J Am Chem Soc 97:1427-1439.
5. Collman JP, Brauman JI, Suslick KS (1975) Oxygen binding to iron porphyrins. J Am Chem Soc 97:7185-7186.
6. Collman JP, Boulatov R, Sunderland CJ, Fu L (2004) Functional analogues of cytochrome c oxidase, myoglobin, and hemoglobin. Chem Rev 104:561-588.
7. Collman JP, Fu L (1999) Synthetic models for hemoglobin and myoglobin. Acc Chem Res 32:455-463.
8. Collman JP, Fu L, Zingg A, Diederich F (1997) Dioxygen and carbon monoxide binding in dendritic iron(II)porphyrins. Chem Comm 2:193-194.
9. Collman JP, et al. (2007) A cytochrome c oxidase model catalyzes oxygen to water reduction under rate-limiting electron flux. Science 315:1565-1568.
10. Collman JP, et al. (2008) Interaction of nitric oxide with a functional model of cytochrome c oxidase. Proc Natl Acad Sci USA 105:9892-9896.
11. Pearce LL, Manzano EL, Martinez-Bosch S, Peterson J (2008) Antagonism of Nitric Oxide Toward the Inhibition of Cytochrome c Oxidase by Carbon Monoxide and Cyanide Chem Res Toxicol 21:2073-2081.
12. Beauchamp ROJ, Bus JS, Popp JA, Boreiko CJ, Andjelkovich DA (1984) A critical review of the literature on hydrogen-sulfide toxicity. Crit Rev Toxicol 65:18-25.
13. Dorman DC, et al. (2002) Cytochrome oxidase inhibition induced by acute hydrogen sulfide inhalation: Correlation with tissue sulfide concentrations in the rat brain, liver, lung, and nasal epithelium Toxicol Sci 65:18-25.
14. Khan AA, et al. (1990) Effects of hydrogen-sulfide exposure on lung mitochondrial respiratory-chain enzymes in rats. Toxicol Appl Pharmacol 103:482-490.
15. Szabo C (2007) Hydrogen sulphide and its therapeutic potential. Nat Rev Drug Discovery 6:917-935.
16. Wang R (2002) Two's company, three's a crowd: Can H2S be the third endogenous gaseous transmitter? FASEB J 16:1792-1798.
17. Lowicka E, Beltowski J (2007) Hydrogen sulfide (H2S) - the third gas for interest for pharmacologists. Pharmalogical Reports 59:4-24.
18. Volpato GP, et al. (2008) Inhaled hydrogen sufide - A rapidly reversible inhibitor of cardiac and metabolic function in the mouse. Anestaesiology 108:659-668.
19. Lee CC (2008) Is human hibernation possible? Annu Rev Med 59:177-186.
20. Blackstone E, Morrison M, Roth MB (2005) H2S induces a suspended animation-like state in mice. Science 308:518.
21. Heldmaier G, Ortmann S, Elvert R (2004) Natural hypometabolism during hibernation and daily torpor in mammals. Respir Physiol Neurobiol 141:317-329.
22. Blackstone E, Roth MB (2007) Suspended animation-like state protects mice from lethal hypoxia. Shock 27:370-372.
23. Cooper CE, Brown GC (2008) The inhibition of mitochondrial cytochrome oxidase by the gases carbon monoxide, nitric oxide, hydrogen cyanide and hydrogen sulfide: Chemical mechanism and physiological significance. J Bionenerg Biomembr 40:533-539.
24. Petersen LC (1977) The effect of inhibitors on the oxygen kinetics of cytochrome c oxidase. Biochim Biophys Acta 460:299-307.
25. Yoshikawa S, et al. (1998) Redox-coupled crystal structural changes in bovine heart cytochrome c oxidase. Science 280:1723-1729.
26. Ferguson Miller S, Babcock GT (1996) Heme/copper terminal oxidases. Chem Rev 96:2889-2907.
27. Iwata S, Ostermeier C, Ludwig B, Michel H (1995) Structure at 2.8A resolution of cytochrome c oxidase from Paracoccus denitrificans. Nature 376:660-669.
28. Ludwig B, et al. (2001) Cytochrome c oxidase and the regulation of oxidative phosphorylation. Chem Bio Chem 2:392-403.
29. Babcock GT, Wikstrom M (1992) Oxygen activation and the conservation of energy in cell respiration. Nature 356:301-309.
30. Collman JP, Decreau RA, Zhang C (2004) Synthesis of cytochrome c oxidase models bearing a Tyr(244) mimic. J Org Chem 69:3546-3549.
31. Collman JP, Gosh S, Dey A, Decreau RA, Yang Y (2009) Catalytic Reduction of O2 by Cytochrome c Using a Synthetic Model of Cytochrome c Oxidase. J Am Chem Soc 131:5034-5035.
32. Sellman D, Lechner P, Knoch F, Moll M (1991) Proof of Strong S-H * - S Bridges in [Ru(SH2)(PPh,)('S4')] * THF, the First H2S Complex Characterized by X-Ray Crystallography. Angew Chem, Int Ed 552-553.
33. Anderson A, Binbrekt S, Tang HC (1977) Raman and infrared study of the low temperature phase of solid H2S and D2S. J Raman Spectrosc 6:213-220.
34. Muladige DC (1994) Binding and Activation of small molecules by Ruthenium complexes containing a chelated aminophosphine ligand. Ph. D. Thesis (Univ of British Colombia, Vancouver, Canada).
35. Kuehn CG, Taube H (1976) Ammineruthenium Complexes of Hydrogen Sulfide and Related Sulfur Ligands. J Am Chem Soc 98:689-702.
36. Collman JP, Decreau RA, Yan Y, Yoon J, Solomon EI (2007) Intramolecular singleturnover reaction in a cytochrome c oxidase model bearing a Tyr244 mimic. J Am Chem Soc 129:5794-5795.
37. Collman JP, Sunderland CJ, Berg KE, Vance MA, Solomon EI (2003) Spectroscopic evidence for a heme-superoxide/Cu(I) intermediate in a functional model of cytochrome c oxidase. J Am Chem Soc 125:6648-6649.
38. Hill BC, et al. (1984) Low-spin ferric forms of cytochrome-a3 in mixed-ligand and partially reduced cyanide-bound derivatives of cytochrome c oxidase. Biochem J 224:591-600.
39. Nicholls P, Kim JK (1982) Sulfide as an inhibitor and electron-donor for the cytochrome c oxidase system. Can J Biochem 60:613-623.