The increase in hepatic uncoupling by fenofibrate contributes to a decrease in adipose tissue in obese rats

Journal of Korean Medical Science

Volumn 22, Issue 2, 2007, Pages 235-241

  Park, Mi Kyoung ^a   Lee, Hye Jeong ^a   Hong, Sook Hee ^a   Choi, Sun Seob ^a   Young, Hyun Yoo ^a   Kyung, Il Lee ^b   Duk, Kyu Kim ^a  

^a Dong A University College of Medicine   (South Korea)

^b Baptist Hospital   (South Korea)

Author keywords

Adiposity; Body temperature; Energy expenditure; Fenofibrate; UCP 3

Indexed keywords

EID: 34248522545     PISSN: 10118934     EISSN: 15986357     Source Type: Journal    
DOI: 10.3346/jkms.2007.22.2.235     Document Type: Article

References (25)

1. Chaput E, Saladin R, Silvestre M, Edgar AD. Fenofibrate and rosiglitazone lower serum triglycerides with opposing effects on body weight. Biochem Biophys Res Commun 2000; 271: 445-50.
2. Mancini FP, Lanni A, Sabatino L, Moreno M, Giannino A, Contaldo F, Colantuoni V, Goglia F. Fenofibrate prevents and reduces body weight gain and adiposity in diet-induced obese rats. FEBS Lett 2001; 491: 1541-58.
3. Koh EH, Kim MS, Park JY, Kim HS, Youn JY, Park HS, Youn JH, Lee KU. Peroxisome proliferator-activated receptor (PPAR)-α activation prevents diabetes in OLETF rats. Diabetes 2003; 52: 2331-7.
4. Mancini FP, Lanni A, Sabatino L, Moreno M, Giannino A, Contaldo F, Colantuoni V, Goglia F. Fenofibrate prevents and reduces body weight gain and adiposity in diet-induced obese rats. FEBS Lett 2001; 491: 154-8.
5. Guerre-Millo M, Gervois P, Raspe E, Madsen L, Poulain P, Derudas B, Herbert JM, Winegar DA, Willson TM, Fruchart JC, Berge RK, Staels B. Peroxisome proliferator-activated receptor α activators improve insulin sensitivity and reduce adiposity. J Biol Chem 2000; 275: 16638-42.
6. Auboeuf D, Rieusset J, Fajas L, Vallier P, Frering V, Riou JP, Staels B, Auwerx J, Laville M, Vidal H. Tissue distribution and quantification of the expression of the peroxisome proliferator activated receptors and of LXR mRNAs in human: effect of obesity and NIDDM in adipose tissue. Diabetes 1997; 46: 1319-27.
7. Staels B, Dallongeville J, Auwerx J, Schoonjans K, Leitersdorf E, Fruchart JC. Mechanism of action of fibrates on lipid and lipoprotein metabolism. Circulation 1998; 98: 2088-93.
8. Ferreira AV, Parreira GG, Green A, Botion LM. Effects of fenofibrate on lipid metabolism in adipose tissue of rats. Metabolism 2006; 55: 731-5.
9. Lee HJ, Choi SS, Park MK, An YJ, Seo SY, Kim MC, Hong SH, Hwang TH, Kang DY, Garber AJ, Kim DK. Fenofibrate lowers abdominal and skeletal adiposity and improves insulin sensitivity in OLETF rats. Biochem Biophys Res Commun 2002; 296: 293-9.
10. Larsen PJ, Jensen PB, Sorensen RV, Larsen LK, Vrang N, Wulff EM, Wassermann K. Differential influences of peroxisome proliferatoractivated receptors gamma and -alpha on food intake and energy homeostasis. Diabetes 2003; 52: 2249-59.
11. Park CW, Zhang Y, Zhang X, Wu J, Chen L, Cha DR, Su D, Hwang MT, Fan X, Davis L, Striker G, Zheng F, Breyer M, Guan Y. PPA-Ralpha agonist fenofibrate improves diabetic nephropathy in db/db mice. Kidney Int 2006; 69: 1511-7.
12. Rothwell NJ, Stock MJ. Brown adipose tissue: does it play a role in the development of obesity? Diabetes Metab Rev 1988; 4: 595-601.
13. Ricquier D, Bouillaud F, Toumelin P, Mory G, Bazin R, Arch J, Penicaud L. 1986 Expression of uncoupling protein mRNA in thermogenic or weakly thermogenic brown adipose tissue. Evidence for a rapid B-adrenoreceptor-mediated and transcriptionally regulated step during activation of thermogenesis. J Biol Chem 1986; 261: 13905-10.
14. Dulloo AG, Samec S, Seydoux J. Uncoupling protein 3 and fatty acid metabolism. Biochem Soc Trans 2001; 29: 785-91.
15. Nisoli E, Carruba MO, Tonello C, Macor C, Federspil G, Vettor R. Induction of fatty acid translocase/CD36, peroxisome proliferator-activated receptor-gamma2, leptin, uncoupling proteins 2 and 3, and tumor necrosis factor-alpha gene expression in human subcutaneous fat by lipid infusion. Diabete 2000; 49: 319-24.
16. Armstrong MB, Towle HC. Polyunsaturated fatty acids stimulate hepatic UCP-2 expression via a PPAR alpha-mediated pathway. Am J Physiol Endocrinol Metab 2001; 281: 1197-204.
17. Cabrero A, Alegret M, Sanchez R, Adzet T, Laguna JC, Vazquez M. Peroxisome proliferator-activated receptor alpha (PPAR alpha) activators, bezafibrate and Wy-14,643, increase uncoupling protein-3 mRNA levels without modifying the mitochondrial membrane potential in primary culture of rat preadipocytes. Arch Biochem Biophys 200; 380: 353-9.
18. Teruel T, Smith SA, Peterson J, Clapham JC. Synergistic activation of UCP-3 expression in cultured fetal rat brown adipocytes by PPAR alpha and PPAR gamma ligands. Biochem Biophys Res Commun 2000; 273: 560-4.
19. Pedraza N, Solanes G, Carmona MC, Iglesias R, Vinas O, Mampel T, Vazquez M, Giralt M, Villarroya F. Impaired expression of the uncoupling protein-3 gene in skeletal muscle during lactation: fibrates and troglitazone reverse lactation-induced downregulation of the uncoupling protein-3 gene. Diabetes 2000; 49: 1224-30.
20. Kelly LJ, Vicario PP, Thompson GM, Candelore MR, Doebber TW, Ventre J, Wu MS, Meurer R, Forrest MJ, Conner MW, Cascieri MA, Moller DE. Peroxisome proliferator-activated receptors gamma and alpha mediate in vivo regulation of uncoupling protein (UCP-1, UCP-2, UCP-3) gene expression. Endocrinology 1998; 139: 4920-7.
21. Berg JM, Tymoczko JL, Stryer L. The Citric Acid Cycle. Biochemistry, 5th ed, New York: WH Freeman & Company 2002; 465-90.
22. Himms-Hagen J, Harper ME. Physiological Role of UCP3 May Be Export of Fatty Acids from Mitochondria When Fatty Acid Oxidation Predominates: An Hypothesis. Exp Biol Med (Maywood) 2001; 226: 78-84.
23. Lanni A, Mancini F, Sabatino L, Silvestri E, Franco R, De Rosa G, Goglia F, Colantuoni V. De novo expression of uncoupling protein 3 is associated to enhanced mitochondrial thioesterase-1 expression and fatty acid metabolism in liver of fenofibrate-treated rats. FEBS Letters 2002; 525: 7-12.
24. Acin A, Rodriguez M, Rique H, Canet E, Boutin JA, Galizzi JP. Cloning and characterization of the 5' flanking region of the human uncoupling protein 3 (UCP3) gene. Biochem Biophys Res Commun 1999; 258: 278-83.
25. Brun S, Carmona MC, Mampel T, Vinas O, Giralt M, Iglesias R, Villarroya F. Activators of peroxisome proliferator-activated receptoralpha induce the expression of the uncoupling protein-3 gene in skeletal muscle: a potential mechanism for the lipid intake-dependent activation of uncoupling protein-3 gene expression at birth. Diabetes 1999; 48: 1217-22.