DOK3 negatively regulates LPS responses and endotoxin tolerance

PLoS ONE

Volumn 7, Issue 6, 2012, Pages

  Peng, Qisheng ^a,b   O'Loughlin, Jason L ^a   Humphrey, Mary Beth ^a,c  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^b JILIN UNIVERSITY   (China)

^c DEPARTMENT OF VETERANS AFFAIRS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOWNSTREAM OF TYROSINE KINASE 3; ENDOTOXIN; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 3; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE PHOSPHATASE SHP 1; SOS PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 1; TOLL LIKE RECEPTOR; UBIQUITIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RESPONSE; DOWN REGULATION; ENZYME ACTIVATION; ENZYME DEFICIENCY; ENZYME DEGRADATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME STABILITY; HYPERSENSITIVITY; IMMUNOREGULATION; IN VIVO STUDY; INNATE IMMUNITY; MACROPHAGE; MOUSE; NONHUMAN; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; STABLE EXPRESSION; UBIQUITINATION; WILD TYPE;

ADAPTATION, PHYSIOLOGICAL; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CELL LINE; CYTOKINES; ENDOTOXINS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HEK293 CELLS; HUMANS; LIPOPOLYSACCHARIDES; MICE; SIGNAL TRANSDUCTION; SOS1 PROTEIN; TOLL-LIKE RECEPTORS; UBIQUITINATION;

MUS;

EID: 84863010670     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0039967     Document Type: Article

References (39)

1. Janeway CA Jr, Medzhitov R, (2002) Innate immune recognition. Annu Rev Immunol 20: 197-216.
2. Nagai Y, Akashi S, Nagafuku M, Ogata M, Iwakura Y, et al. (2002) Essential role of MD-2 in LPS responsiveness and TLR4 distribution. Nat Immunol 3: 667-672.
3. Takeda K, Kaisho T, Akira S, (2003) Toll-like receptors. Annu Rev Immunol 21: 335-376.
4. Akashi S, Saitoh S, Wakabayashi Y, Kikuchi T, Takamura N, et al. (2003) Lipopolysaccharide interaction with cell surface Toll-like receptor 4-MD-2: higher affinity than that with MD-2 or CD14. J Exp Med 198: 1035-1042.
5. Green NM, Marshak-Rothstein A, (2011) Toll-like receptor driven B cell activation in the induction of systemic autoimmunity. Semin Immunol 23: 106-112.
6. Burrell R, (1994) Human responses to bacterial endotoxin. Circ Shock 43: 137-153.
7. McCall CE, Grosso-Wilmoth LM, LaRue K, Guzman RN, Cousart SL, (1993) Tolerance to endotoxin-induced expression of the interleukin-1 beta gene in blood neutrophils of humans with the sepsis syndrome. J Clin Invest 91: 853-861.
8. Kobayashi K, Hernandez LD, Galan JE, Janeway CA Jr, Medzhitov R, et al. (2002) IRAK-M is a negative regulator of Toll-like receptor signaling. Cell 110: 191-202.
9. Sly LM, Rauh MJ, Kalesnikoff J, Song CH, Krystal G, (2004) LPS-induced upregulation of SHIP is essential for endotoxin tolerance. Immunity 21: 227-239.
10. Nakagawa R, Naka T, Tsutsui H, Fujimoto M, Kimura A, et al. (2002) SOCS-1 participates in negative regulation of LPS responses. Immunity 17: 677-687.
11. An H, Xu H, Zhang M, Zhou J, Feng T, et al. (2005) Src homology 2 domain-containing inositol-5-phosphatase 1 (SHIP1) negatively regulates TLR4-mediated LPS response primarily through a phosphatase activity- and PI-3K-independent mechanism. Blood 105: 4685-4692.
12. Pan H, Ding E, Hu M, Lagoo AS, Datto MB, et al. (2010) SMAD4 is required for development of maximal endotoxin tolerance. J Immunol 184: 5502-5509.
13. Keck S, Freudenberg M, Huber M, (2010) Activation of murine macrophages via TLR2 and TLR4 is negatively regulated by a Lyn/PI3K module and promoted by SHIP1. J Immunol 184: 5809-5818.
14. Sahay B, Patsey RL, Eggers CH, Salazar JC, Radolf JD, et al. (2009) CD14 signaling restrains chronic inflammation through induction of p38-MAPK/SOCS-dependent tolerance. PLoS Pathog 5: e1000687.
15. Mansell A, Smith R, Doyle SL, Gray P, Fenner JE, et al. (2006) Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation. Nat Immunol 7: 148-155.
16. Mashima R, Hishida Y, Tezuka T, Yamanashi Y, (2009) The roles of Dok family adapters in immunoreceptor signaling. Immunol Rev 232: 273-285.
17. Shinohara H, Inoue A, Toyama-Sorimachi N, Nagai Y, Yasuda T, et al. (2005) Dok-1 and Dok-2 are negative regulators of lipopolysaccharide-induced signaling. J Exp Med 201: 333-339.
18. Cong F, Yuan B, Goff SP, (1999) Characterization of a novel member of the DOK family that binds and modulates Abl signaling. Mol Cell Biol 19: 8314-8325.
19. Honma M, Higuchi O, Shirakata M, Yasuda T, Shibuya H, et al. (2006) Dok-3 sequesters Grb2 and inhibits the Ras-Erk pathway downstream of protein-tyrosine kinases. Genes Cells 11: 143-151.
20. Lemay S, Davidson D, Latour S, Veillette A, (2000) Dok-3, a novel adapter molecule involved in the negative regulation of immunoreceptor signaling. Mol Cell Biol 20: 2743-2754.
21. Robson JD, Davidson D, Veillette A, (2004) Inhibition of the Jun N-terminal protein kinase pathway by SHIP-1, a lipid phosphatase that interacts with the adaptor molecule Dok-3. Mol Cell Biol 24: 2332-2343.
22. Ng CH, Xu S, Lam KP, (2007) Dok-3 plays a nonredundant role in negative regulation of B-cell activation. Blood 110: 259-266.
23. Davies GC, Ettenberg SA, Coats AO, Mussante M, Ravichandran S, et al. (2004) Cbl-b interacts with ubiquitinated proteins; differential functions of the UBA domains of c-Cbl and Cbl-b. Oncogene 23: 7104-7115.
24. Bachmaier K, Krawczyk C, Kozieradzki I, Kong YY, Sasaki T, et al. (2000) Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b. Nature 403: 211-216.
25. Han C, Jin J, Xu S, Liu H, Li N, et al. (2010) Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b. Nat Immunol 11: 734-742.
26. Berger AH, Niki M, Morotti A, Taylor BS, Socci ND, et al. (2010) Identification of DOK genes as lung tumor suppressors. Nat Genet 42: 216-223.
27. Kawai T, Akira S, (2011) Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. Immunity 34: 637-650.
28. Hunter T, (2007) The age of crosstalk: phosphorylation, ubiquitination, and beyond. Mol Cell 28: 730-738.
29. Janas JA, Van Aelst L, (2011) Oncogenic tyrosine kinases target Dok-1 for ubiquitin-mediated proteasomal degradation to promote cell transformation. Mol Cell Biol 31: 2552-2565.
30. Senis YA, Antrobus R, Severin S, Parguina AF, Rosa I, et al. (2009) Proteomic analysis of integrin alphaIIbbeta3 outside-in signaling reveals Src-kinase-independent phosphorylation of Dok-1 and Dok-3 leading to SHIP-1 interactions. J Thromb Haemost 7: 1718-1726.
31. Pierre S, Bats AS, Coumoul X, (2011) Understanding SOS (Son of Sevenless). Biochem Pharmacol 82: 1049-1056.
32. Pierre S, Bats AS, Chevallier A, Bui LC, Ambolet-Camoit A, et al. (2011) Induction of the Ras activator Son of Sevenless 1 by environmental pollutants mediates their effects on cellular proliferation. Biochem Pharmacol 81: 304-313.
33. Shimauchi H, Ogawa T, Okuda K, Kusumoto Y, Okada H, (1999) Autoregulatory effect of interleukin-10 on proinflammatory cytokine production by Porphyromonas gingivalis lipopolysaccharide-tolerant human monocytes. Infect Immun 67: 2153-2159.
34. Sly LM, Ho V, Antignano F, Ruschmann J, Hamilton M, et al. (2007) The role of SHIP in macrophages. Front Biosci 12: 2836-2848.
35. Frankenberger M, Pechumer H, Ziegler-Heitbrock HW, (1995) Interleukin-10 is upregulated in LPS tolerance. J Inflamm 45: 56-63.
36. Alves-Rosa F, Vulcano M, Beigier-Bompadre M, Fernandez G, Palermo M, et al. (2002) Interleukin-1beta induces in vivo tolerance to lipopolysaccharide in mice. Clin Exp Immunol 128: 221-228.
37. Tanabe SI, Grenier D, (2008) Macrophage tolerance response to Aggregatibacter actinomycetemcomitans lipopolysaccharide induces differential regulation of tumor necrosis factor-alpha, interleukin-1 beta and matrix metalloproteinase 9 secretion. J Periodontal Res 43: 372-377.
38. Peng Q, Malhotra S, Torchia JA, Kerr WG, Coggeshall KM, et al. (2010) TREM2- and DAP12-dependent activation of PI3K requires DAP10 and is inhibited by SHIP1. Sci Signal 3: ra38.
39. Mocsai A, Humphrey MB, Van Ziffle JA, Hu Y, Burghardt A, et al. (2004) The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRgamma) regulate development of functional osteoclasts through the Syk tyrosine kinase. Proc Natl Acad Sci U S A 101: 6158-6163.