Selenium is a modulator of circadian clock that protects mice from the toxicity of a chemotherapeutic drug via upregulation of the core clock protein, BMAL1

Oncotarget

Volumn 2, Issue 12, 2011, Pages 1279-1290

  Hu, Yan ^a   Spengler, Mary L ^a   Kuropatwinski, Karen K ^a   Comas, Maria ^a   Jackson, Marilyn ^a   Chernov, Mikhail V ^a   Gleiberman, Anatoly S ^b   Fedtsova, Natalia ^a   Rustum, Youcef M ^a   Gudkov, Andrei V ^a   Antoch, Marina P ^a  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

^b CLEVELAND BIOLABS INC   (United States)

Author keywords

Anticancer treatment; Circadian rhythms; Cyclophosphamide; L Methyl selenocysteine; Liver; Tieg1; Transcription

Indexed keywords

ARNTL PROTEIN, MOUSE; CIRCADIAN RHYTHM SIGNALING PROTEIN; CLOCK PROTEIN, MOUSE; CYCLOPHOSPHAMIDE; CYSTEINE; DNA BINDING PROTEIN; DRUG DERIVATIVE; ORGANOSELENIUM DERIVATIVE; PER1 PROTEIN, MOUSE; SELENIUM DERIVATIVE; SELENOMETHYLSELENOCYSTEINE; SMALL INTERFERING RNA; TIEG1 PROTEIN, MOUSE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ARNTL; TRANSCRIPTION FACTOR CLOCK;

ANIMAL; ARTICLE; C57BL MOUSE; CELL STRAIN HEK293; CIRCADIAN RHYTHM; FEMALE; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; HUMAN; METABOLISM; MOUSE; NEOPLASM; PROMOTER REGION; RNA INTERFERENCE; TRANSCRIPTION INITIATION; TUMOR CELL LINE;

ANIMALS; ARNTL TRANSCRIPTION FACTORS; CELL LINE, TUMOR; CIRCADIAN CLOCKS; CLOCK PROTEINS; CYCLOPHOSPHAMIDE; CYSTEINE; DNA-BINDING PROTEINS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HEK293 CELLS; HUMANS; MICE; MICE, INBRED C57BL; NEOPLASMS; ORGANOSELENIUM COMPOUNDS; PERIOD CIRCADIAN PROTEINS; PROMOTER REGIONS, GENETIC; RNA INTERFERENCE; RNA, SMALL INTERFERING; SELENIUM COMPOUNDS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION;

EID: 84862987210     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.411     Document Type: Article

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