Interactivating feedback loops within the mammalian clock: BMAL1 is negatively autoregulated and upregulated by CRY1, CRY2, and PER2

Biochemical and Biophysical Research Communications

Volumn 290, Issue 3, 2002, Pages 933-941

  Yu, Wangjie ^a   Nomura, Masahiko ^a   Ikeda, Masaaki ^a  

^a SAITAMA MEDICAL UNIVERSITY   (Japan)

Author keywords

BMAL1; Circadian clock; Circadian rhythm; CLOCK; CRY; PER

Indexed keywords

PER2 PROTEIN; PROTEIN; PROTEIN BMAL1; PROTEIN CRY1; PROTEIN CRY2; UNCLASSIFIED DRUG;

ARTICLE; AUTOREGULATION; CIRCADIAN RHYTHM; FEEDBACK SYSTEM; GENE STRUCTURE; GENETIC TRANSCRIPTION; MODEL; MOLECULAR CLOCK; NEGATIVE FEEDBACK; OSCILLATION; PERIODICITY; PRIORITY JOURNAL; PROMOTER REGION; STRUCTURE ANALYSIS; TIME; TRANSCRIPTION REGULATION;

MAMMALIA;

EID: 0036290425     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2001.6300     Document Type: Article

References (37)

1. Molecular bases for circadian clocks
2. Genetics of the mammalian circadian system: Photic entrainment, circadian pacemaker mechanisms, and posttranslational regulation
3. Molecular components of the circadian system in Drosophila
4. Molecular analysis of mammalian circadian rhythms
5. A serum shock induces circadian gene expression in mammalian tissue culture cells
6. Involvement of the MAP kinase cascade in resetting of the mammalian circadian clock
7. Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: A humoral mechanism to reset a peripheral clock
8. cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS protein (BMAL1) and identification of alternatively spliced variants with alternative translation initiation site usage
9. Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway
10. Positional cloning of the mouse circadian clock gene
11. Functional identification of the mouse circadian Clock gene by transgenic BAC rescue
12. Role of the CLOCK protein in the mammalian circadian mechanism
13. Mop3 is an essential component of the master circadian pacemaker in mammals
14. Nonredundant roles of the mPer1 and mPer2 genes in the mammalian circadian clock
15. The mPer2 gene encodes a functional component of the mammalian circadian clock
16. Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms
17. mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop
18. Targeted disruption of the mPer3 gene: Subtle effects on circadian clock function
19. dCLOCK is present in limiting amounts and likely mediates daily interactions between the dCLOCK-CYC transcription factor and the PER-TIM complex
20. Circadian oscillation of BMAL1, a partner of a mammalian clock gene Clock, in rat suprachiasmatic nucleus
21. Light and glutamate-induced degradation of the circadian oscillating protein BMAL1 during the mammalian clock resetting
22. Circadian oscillation of a mammalian homologue of the Drosophila period gene
23. Multitissue circadian expression of rat period homolog (rPer2) mRNA is governed by the mammalian circadian clock, the suprachiasmatic nucleus in the brain
24. Photic induction of mPer1 and mPer2 in cry-deficient mice lacking a biological clock
25. Phase-dependent induction by light of rat Clock gene expression in the suprachiasmatic nucleus
26. Interlocked feedback loops within the Drosophila circadian oscillator
27. Interacting molecular loops in the mammalian circadian clock
28. Characterization of three splice variants and genomic organization of the mouse BMAL1 gene
29. Analysis of clock proteins in mouse SCN demonstrates phylogenetic divergence of the circadian clockwork and resetting mechanisms
30. Light-independent role of CRY1 and CRY2 in the mammalian circadian clock
31. Dimerization and nuclear entry of mPER proteins in mammalian cells
32. NPAS2: An analog of clock operative in the mammalian fore-brain
33. Expression of basic helix-loop-helix/PAS genes in the mouse suprachiasmatic nucleus
34. Interlocked feedback loops contribute to the robustness of the Neurospora circadian clock
35. Interconnected feedback loops in the Neurospora circadian system
36. Positional syntenic cloning and functional characterization of the mammalian circadian mutation tau
37. An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome