The neuroprotective potential of cyanidin-3-glucoside fraction extracted from mulberry following oxygen-glucose deprivation

Korean Journal of Physiology and Pharmacology

Volumn 15, Issue 6, 2011, Pages 353-361

  Bhuiyan, Mohammad Iqbal Hossain ^a   Kim, Hyun Bok ^b   Kim, Seong Yun ^a   Cho, Kyung Ok ^a  

^a The Catholic University of Korea   (South Korea)

^b National Institute of Animal Science   (South Korea)

Author keywords

Cyanidin 3 glucoside; Glutamate; Morus alba L.; Neuroprotection; Oxygen glucose deprivation

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; CYANIDIN 3 GLUCOSIDE; GLUTAMIC ACID; LACTATE DEHYDROGENASE; RHODAMINE 123;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN CELL; CELL ASSAY; CELL HYPOXIA; CONTROLLED STUDY; FLUORESCENCE ANALYSIS; IN VITRO STUDY; MEMBRANE DAMAGE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MULBERRY; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; RAT;

EID: 84862917387     PISSN: 12264512     EISSN: None     Source Type: Journal    
DOI: 10.4196/kjpp.2011.15.6.353     Document Type: Article

References (43)

1. American Heart Association. Heart disease and stroke statistics-2008 update. Dallas, Texas. 2008.
2. O'Collins VE, Macleod MR, Donnan GA, Horky LL, van der Worp BH, Howells DW. 1,026 experimental treatments in acute stroke. Ann Neurol. 2006;59:467-477. (Pubitemid 43358067)
3. Lee KE, Kim SK, Cho KO, Kim SY. Pre-ischemic treatment with ampicillin reduces neuronal damage in the mouse hippocampus and neostriatum after transient forebrain ischemia. Korean J Physiol Pharmacol. 2008;12:287-291.
4. Cho KO, Kim SK, Cho YJ, Sung KW, Kim SY. Regional differences in the neuroprotective effect of minocycline in a mouse model of global forebrain ischemia. Life Sci. 2007;80:2030-2035. (Pubitemid 46678062)
5. Coyle JT, Puttfarcken P. Oxidative stress, glutamate, and neurodegenerative disorders. Science. 1993;262:689-695. (Pubitemid 23350687)
6. Tan S, Wood M, Maher P. Oxidative stress induces a form of programmed cell death with characteristics of both apoptosis and necrosis in neuronal cells. J Neurochem. 1998;71:95-105. (Pubitemid 28292539)
7. Lipton P. Ischemic cell death in brain neurons. Physiol Rev. 1999;79:1431-1568. (Pubitemid 29473320)
8. Choi DW, Rothman SM. The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death. Annu Rev Neurosci. 1990;13:171-182. (Pubitemid 20100647)
9. Kontos HA. Oxygen radicals in cerebral ischemia: the 2001 Willis lecture. Stroke. 2001;32:2712-2716. (Pubitemid 33055333)
10. Warner DS, Sheng H, Batinić-Haberle I. Oxidants, antioxidants and the ischemic brain. J Exp Biol. 2004;207:3221-3231. (Pubitemid 39275296)
11. Niizuma K, Endo H, Chan PH. Oxidative stress and mitochondrial dysfunction as determinants of ischemic neuronal death and survival. J Neurochem. 2009;109 Suppl 1:133-138.
12. Cherubini A, Ruggiero C, Morand C, Lattanzio F, Dell'aquila G, Zuliani G, Di Iorio A, Andres-Lacueva C. Dietary antioxidants as potential pharmacological agents for ischemic stroke. Curr Med Chem. 2008;15:1236-1248. (Pubitemid 351997810)
13. Slemmer JE, Shacka JJ, Sweeney MI, Weber JT. Antioxidants and free radical scavengers for the treatment of stroke, traumatic brain injury and aging. Curr Med Chem. 2008;15:404-414. (Pubitemid 351266946)
14. Andres-Lacueva C, Shukitt-Hale B, Galli RL, Jauregui O, Lamuela-Raventos RM, Joseph JA. Anthocyanins in aged blueberry-fed rats are found centrally and may enhance memory. Nutr Neurosci. 2005;8:111-120. (Pubitemid 40959652)
15. Margaill I, Plotkine M, Lerouet D. Antioxidant strategies in the treatment of stroke. Free Radic Biol Med. 2005;39:429-443. (Pubitemid 41021642)
16. Vokó Z, Hollander M, Hofman A, Koudstaal PJ, Breteler MM. Dietary antioxidants and the risk of ischemic stroke: the Rotterdam Study. Neurology. 2003;61:1273-1275. (Pubitemid 37377554)
17. Amorini AM, Lazzarino G, Galvano F, Fazzina G, Tavazzi B, Galvano G. Cyanidin-3-O-beta-glucopyranoside protects myocardium and erythrocytes from oxygen radical-mediated damages. Free Radic Res. 2003;37:453-460. (Pubitemid 36244897)
18. Tsuda T, Horio F, Kitoh J, Osawa T. Protective effects of dietary cyanidin 3-O-beta-D-glucoside on liver ischemia-reperfusion injury in rats. Arch Biochem Biophys. 1999;368:361-366. (Pubitemid 29406562)
19. Kang TH, Hur JY, Kim HB, Ryu JH, Kim SY. Neuroprotective effects of the cyanidin-3-O-beta-d-glucopyranoside isolated from mulberry fruit against cerebral ischemia. Neurosci Lett. 2006;391:122-126.
20. Kim KT, Nam TK, Park YS, Kim YB, Park SW. Neuroprotective effect of anthocyanin on experimental traumatic spinal cord injury. J Korean Neurosurg Soc. 2011;49:205-211.
21. Heo HJ, Lee CY. Strawberry and its anthocyanins reduce oxidative stress-induced apoptosis in PC12 cells. J Agric Food Chem. 2005;53:1984-1989.
22. Kim HB, Kim SL. Identification of C3G (cyanidin-3-glucoside) from mulberry fruits and quantification with different varieties. Korean J Serie Sci. 2003;45:90-95.
23. Kim HB, Kim SL, Koh SH, Seok YS, Kim YS, Sung GB, Kang PD. The development of natural pigment with mulberry fruit as a food additive. Korean J Crop Sci. 2011;56:18-22.
24. Bhuiyan MI, Islam MN, Jung SY, Yoo HH, Lee YS, Jin C. Involvement of ceramide in ischemic tolerance induced by preconditioning with sublethal oxygen-glucose deprivation in primary cultured cortical neurons of rats. Biol Pharm Bull. 2010;33:11-17.
25. Bhuiyan MI, Jung SY, Kim HJ, Lee YS, Jin C. Major role of the PI3K/Akt pathway in ischemic tolerance induced by sublethal oxygen-glucose deprivation in cortical neurons in vitro. Arch Pharm Res. 2011;34:1023-1034.
26. Brewer GJ, Torricelli JR, Evege EK, Price PJ. Optimized survival of hippocampal neurons in B27-supplemented Neurobasal, a new serum-free medium combination. J Neurosci Res. 1993;35:567-576. (Pubitemid 23215708)
27. Lesuisse C, Martin LJ. Immature and mature cortical neurons engage different apoptotic mechanisms involving caspase-3 and the mitogen-activated protein kinase pathway. J Cereb Blood Flow Metab. 2002;22:935-950. (Pubitemid 34831600)
28. Serraino I, Dugo L, Dugo P, Mondello L, Mazzon E, Dugo G, Caputi AP, Cuzzocrea S. Protective effects of cyanidin-3-O-glucoside from blackberry extract against peroxynitrite-induced endothelial dysfunction and vascular failure. Life Sci. 2003;73:1097-1114. (Pubitemid 36724913)
29. Mitcheva M, Astroug H, Drenska D, Popov A, Kassarova M. Biochemical and morphological studies on the effects of anthocyans and vitamin E on carbon tetrachloride induced liver injury. Cell Mol Biol (Noisy-le-grand). 1993;39:443-448.
30. Matsunaga N, Imai S, Inokuchi Y, Shimazawa M, Yokota S, Araki Y, Hara H. Bilberry and its main constituents have neuroprotective effects against retinal neuronal damage in vitro and in vivo. Mol Nutr Food Res. 2009;53:869-877.
31. Tarozzi A, Morroni F, Merlicco A, Bolondi C, Teti G, Falconi M, Cantelli-Forti G, Hrelia P. Neuroprotective effects of cyanidin 3-O-glucopyranoside on amyloid beta (25-35) oligomer-induced toxicity. Neurosci Lett. 2010;473:72-76.
32. Kapinya KJ, Löwl D, Fütterer C, Maurer M, Waschke KF, Isaev NK, Dirnagl U. Tolerance against ischemic neuronal injury can be induced by volatile anesthetics and is inducible NO synthase dependent. Stroke. 2002;33:1889-1898. (Pubitemid 34761081)
33. Pérez-Pinzón MA, Tao L, Nicholson C. Extracellular potassium, volume fraction, and tortuosity in rat hippocampal CA1, CA3, and cortical slices during ischemia. J Neurophysiol. 1995;74:565-573.
34. Goldberg MP, Choi DW. Combined oxygen and glucose deprivation in cortical cell culture: calcium-dependent and calcium-independent mechanisms of neuronal injury. J Neurosci. 1993;13:3510-3524. (Pubitemid 23241187)
35. Aizenman Y, de Vellis J. Brain neurons develop in a serum and glial free environment: effects of transferrin, insulin, insulin-like growth factor-I and thyroid hormone on neuronal survival, growth and differentiation. Brain Res. 1987;406:32-42. (Pubitemid 17048386)
36. Lindsay RM. Adult rat brain astrocytes support survival of both NGF-dependent and NGF-insensitive neurones. Nature. 1979;282:80-82. (Pubitemid 10250113)
37. Jones PA, May GR, McLuckie JA, Iwashita A, Sharkey J. Apoptosis is not an invariable component of in vitro models of cortical cerebral ischaemia. Cell Res. 2004;14:241-250. (Pubitemid 43231822)
38. Andjelković M, Jakubowicz T, Cron P, Ming XF, Han JW, Hemmings BA. Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors. Proc Natl Acad Sci USA. 1996;93:5699-5704. (Pubitemid 26190743)
39. Benveniste H, Drejer J, Schousboe A, Diemer NH. Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis. J Neurochem. 1984;43:1369-1374. (Pubitemid 15205893)
40. Park CK, Nehls DG, Graham DI, Teasdale GM, McCulloch J. The glutamate antagonist MK-801 reduces focal ischemic brain damage in the rat. Ann Neurol. 1988;24:543-551.
41. Alix JJ, Fern R. Glutamate receptor-mediated ischemic injury of premyelinated central axons. Ann Neurol. 2009;66:682-693.
42. Khkönen MP, Heinmki J, Ollilainen V, Heinonen M. Berry anthocyanins: isolation, identification and antioxidant activities. J Sci Food Agric. 2003;83:1403-1411. (Pubitemid 37374929)
43. Ziberna L, Lunder M, Moze S, Vanzo A, Tramer F, Passamonti S, Drevensek G. Acute cardioprotective and cardiotoxic effects of bilberry anthocyanins in ischemia-reperfusion injury: beyond concentration-dependent antioxidant activity. Cardiovasc Toxicol. 2010;10:283-294.