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Volumn 309, Issue 3, 2004, Pages 1154-1159

Deletion of the fyn-kinase gene alters sensitivity to GABAergic drugs: Dependence on β2/β3 GABAA receptor subunits

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; ETOMIDATE; FLUNITRAZEPAM; GABA A RECEPTOR BETA2; GABA A RECEPTOR BETA3; GABOXADOL; MUSCIMOL; PROTEIN KINASE FYN; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG; ZOLPIDEM;

EID: 2442682865     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.103.064444     Document Type: Article
Times cited : (25)

References (35)
  • 4
    • 0000313395 scopus 로고
    • The up-and-down method for small samples
    • Dixon WJ (1965) The up-and-down method for small samples. J Am Stat Assoc 60:967-978.
    • (1965) J Am Stat Assoc , vol.60 , pp. 967-978
    • Dixon, W.J.1
  • 6
    • 0031452190 scopus 로고    scopus 로고
    • Differences in agonist/antagonist binding affinity and receptor transduction using recombinant human γ-aminobutyric acid type A receptors
    • Ebert B, Thompson SA, Saounatsou K, McKernan R, Krogsgaard-Larsen P, and Wafford KA (1997) Differences in agonist/antagonist binding affinity and receptor transduction using recombinant human γ-aminobutyric acid type A receptors. Mol Pharmacol 52:1150-1156.
    • (1997) Mol Pharmacol , vol.52 , pp. 1150-1156
    • Ebert, B.1    Thompson, S.A.2    Saounatsou, K.3    McKernan, R.4    Krogsgaard-Larsen, P.5    Wafford, K.A.6
  • 7
    • 0028171397 scopus 로고
    • Molecular pharmacology of γ-aminobutyric acid type A receptor agonists and partial agonists in oocytes injected with different α, β and γ receptor subunit combinations
    • Ebert B, Wafford KA, Whiting PJ, Krogsgaard-Larsen P, and Kemp JA (1994) Molecular pharmacology of γ-aminobutyric acid type A receptor agonists and partial agonists in oocytes injected with different α, β and γ receptor subunit combinations. Mol Pharmacol 46:957-963.
    • (1994) Mol Pharmacol , vol.46 , pp. 957-963
    • Ebert, B.1    Wafford, K.A.2    Whiting, P.J.3    Krogsgaard-Larsen, P.4    Kemp, J.A.5
  • 8
    • 0028977843 scopus 로고
    • GABAA-receptor heterogeneity in adult rat brain: Differential regional and cellular distribution of seven major subunits
    • Fritschy JM and Mohler H (1995) GABAA-receptor heterogeneity in adult rat brain: Differential regional and cellular distribution of seven major subunits. J Comp Neurol 359:154-194.
    • (1995) J Comp Neurol , vol.359 , pp. 154-194
    • Fritschy, J.M.1    Mohler, H.2
  • 9
    • 0022362316 scopus 로고
    • Functional coupling of γ-aminobutyric acid receptors to chloride channels in brain membranes
    • Harris RA and Allan AM (1985) Functional coupling of γ -aminobutyric acid receptors to chloride channels in brain membranes. Science (Wash DC) 228:1108-1110.
    • (1985) Science (Wash DC) , vol.228 , pp. 1108-1110
    • Harris, R.A.1    Allan, A.M.2
  • 10
    • 0021985629 scopus 로고
    • Correlation of Purkinje neuron depression and hypnotic effects of ethanol in inbred strains of rats
    • Johnson SW, Hoffer BJ, Baker R, and Freedman R (1985) Correlation of Purkinje neuron depression and hypnotic effects of ethanol in inbred strains of rats. Alcohol Clin Exp Res 9:56-58.
    • (1985) Alcohol Clin Exp Res , vol.9 , pp. 56-58
    • Johnson, S.W.1    Hoffer, B.J.2    Baker, R.3    Freedman, R.4
  • 12
    • 0031891855 scopus 로고    scopus 로고
    • Abnormal synaptic transmission in the olfactory bulb of fyn-kinase-deficient mice
    • Kitazawa H, Yagi T, Miyakawa T, Niki H, and Kawai N (1998) Abnormal synaptic transmission in the olfactory bulb of fyn-kinase-deficient mice. J Neurophysiol 79:137-142.
    • (1998) J Neurophysiol , vol.79 , pp. 137-142
    • Kitazawa, H.1    Yagi, T.2    Miyakawa, T.3    Niki, H.4    Kawai, N.5
  • 13
    • 0026615268 scopus 로고
    • The distribution of thirteen GABAA receptor subunit mRNAs in rat brain. III. Embryonic and postnatal development
    • Laurie DJ, Wisden W, and Seeburg PH (1992) The distribution of thirteen GABAA receptor subunit mRNAs in rat brain. III. Embryonic and postnatal development. J Neurosci 12:4151-4172.
    • (1992) J Neurosci , vol.12 , pp. 4151-4172
    • Laurie, D.J.1    Wisden, W.2    Seeburg, P.H.3
  • 14
    • 0032234901 scopus 로고    scopus 로고
    • The cerebellum, predictive control and motor coordination
    • Miall RC (1998) The cerebellum, predictive control and motor coordination. Novartis Found Symp 218:272-290.
    • (1998) Novartis Found Symp , vol.218 , pp. 272-290
    • Miall, R.C.1
  • 17
    • 0345802987 scopus 로고    scopus 로고
    • Subunit composition and quantitative importance of GABAA receptor subtypes in the cerebellum of mouse and rat
    • Pöltl A, Hauer B, Fuchs K, Tretter V, and Sieghart W (2003) Subunit composition and quantitative importance of GABAA receptor subtypes in the cerebellum of mouse and rat. J Neurochem 87:1444-1455.
    • (2003) J Neurochem , vol.87 , pp. 1444-1455
    • Pöltl, A.1    Hauer, B.2    Fuchs, K.3    Tretter, V.4    Sieghart, W.5
  • 18
    • 0031936716 scopus 로고    scopus 로고
    • Anesthesia sensitivity in mice that lack the β3 subunit of the γ-aminobutyric acid type A receptor
    • Quinlan JJ, Homanics GE, and Firestone LL (1998) Anesthesia sensitivity in mice that lack the β3 subunit of the γ-aminobutyric acid type A receptor. Anesthesiology 88:775-780.
    • (1998) Anesthesiology , vol.88 , pp. 775-780
    • Quinlan, J.J.1    Homanics, G.E.2    Firestone, L.L.3
  • 19
    • 0028243253 scopus 로고
    • Model of subunit composition of γ-aminobutyric acid type A receptor subtypes expressed in rat cerebellum with respect to their α and γ/δ subunits
    • Quirk K, Gillard NP, Pagan CI, Whiting PJ, and McKeman RM (1994) Model of subunit composition of γ-aminobutyric acid type A receptor subtypes expressed in rat cerebellum with respect to their α and γ/δ subunits. J Biol Chem 269:16020-16028.
    • (1994) J Biol Chem , vol.269 , pp. 16020-16028
    • Quirk, K.1    Gillard, N.P.2    Pagan, C.I.3    Whiting, P.J.4    McKeman, R.M.5
  • 21
    • 0029967726 scopus 로고    scopus 로고
    • Properties of putative cerebellar γ-aminobutyric acid A receptor isoforms
    • Saxena NC and Macdonald RL (1996) Properties of putative cerebellar γ-aminobutyric acid A receptor isoforms. Mol Pharmacol 49:567-579.
    • (1996) Mol Pharmacol , vol.49 , pp. 567-579
    • Saxena, N.C.1    Macdonald, R.L.2
  • 22
    • 0037169504 scopus 로고    scopus 로고
    • Srcasm: A novel src activating and signaling molecule
    • Seykora JT, Mei L, Dotto GP, and Stein PL (2002) Srcasm: a novel src activating and signaling molecule. J Biol Chem 277:2812-2822.
    • (2002) J Biol Chem , vol.277 , pp. 2812-2822
    • Seykora, J.T.1    Mei, L.2    Dotto, G.P.3    Stein, P.L.4
  • 23
    • 0034968902 scopus 로고    scopus 로고
    • A) receptor subunits and benzodiazepine binding: Significance to clinical syndromes and their treatment
    • A) receptor subunits and benzodiazepine binding: significance to clinical syndromes and their treatment. Br J Biomed Sci 58:111-121.
    • (2001) Br J Biomed Sci , vol.58 , pp. 111-121
    • Smith, T.A.1
  • 24
    • 0026612411 scopus 로고
    • fyn mutant mice display differential signaling in thymocytes and peripheral T cells
    • fyn mutant mice display differential signaling in thymocytes and peripheral T cells. Cell 70:741-750.
    • (1992) Cell , vol.70 , pp. 741-750
    • Stein, P.L.1    Lee, H.M.2    Rich, S.3    Soriano, P.4
  • 25
    • 0028889715 scopus 로고
    • NMDA receptor subunits ε1 (NR2A) and ε2 (NR2B) are substrates for Fyn in the postsynaptic density fraction isolated from the rat brain
    • Suzuki T and Okumura-Noji K (1995) NMDA receptor subunits ε1 (NR2A) and ε2 (NR2B) are substrates for Fyn in the postsynaptic density fraction isolated from the rat brain. Biochem Biophys Res Commun 216:582-588.
    • (1995) Biochem Biophys Res Commun , vol.216 , pp. 582-588
    • Suzuki, T.1    Okumura-Noji, K.2
  • 26
    • 0031910550 scopus 로고    scopus 로고
    • Stereoselective effects of etomidate optical isomers on γ-aminobutyric acid type A receptors and animals
    • Tomlin SL, Jenkins A, Lieb WR, and Franks NP (1998) Stereoselective effects of etomidate optical isomers on γ-aminobutyric acid type A receptors and animals. Anesthesiology 88:708-717.
    • (1998) Anesthesiology , vol.88 , pp. 708-717
    • Tomlin, S.L.1    Jenkins, A.2    Lieb, W.R.3    Franks, N.P.4
  • 28
    • 0029786719 scopus 로고    scopus 로고
    • Functional characterization of human γ-aminobutyric acid A receptors containing the α4 subunit
    • Wafford KA, Thompson SA, Thomas D, Sikela J, Wilcox AS, and Whiting PJ (1996) Functional characterization of human γ-aminobutyric acid A receptors containing the α4 subunit. Mol Pharmacol 50:670-678.
    • (1996) Mol Pharmacol , vol.50 , pp. 670-678
    • Wafford, K.A.1    Thompson, S.A.2    Thomas, D.3    Sikela, J.4    Wilcox, A.S.5    Whiting, P.J.6
  • 29
    • 0345598083 scopus 로고    scopus 로고
    • Ethanol enhances α4β3δ and α6β3δ γ-aminobutyric acid type A receptors at low concentrations known to affect humans
    • Wallner M, Hanchar HJ, and Olsen RW (2004) Ethanol enhances α4β3δ and α6β3δ γ-aminobutyric acid type A receptors at low concentrations known to affect humans. Proc Natl Acad Sci USA 100:15218-15223.
    • (2004) Proc Natl Acad Sci USA , vol.100 , pp. 15218-15223
    • Wallner, M.1    Hanchar, H.J.2    Olsen, R.W.3
  • 30
    • 0030610402 scopus 로고    scopus 로고
    • Modulation of GABAA receptor function by tyrosine phosphorylation of β subunits
    • Wan Q, Man HY, Braunton J, Wang W, Salter MW, Becker L, and Wang YT (1997) Modulation of GABAA receptor function by tyrosine phosphorylation of β subunits. J Neurosci 17:5062-5069.
    • (1997) J Neurosci , vol.17 , pp. 5062-5069
    • Wan, Q.1    Man, H.Y.2    Braunton, J.3    Wang, W.4    Salter, M.W.5    Becker, L.6    Wang, Y.T.7
  • 31
    • 0028583107 scopus 로고
    • Src family kinases control neural development and function
    • Yagi T (1994) Src family kinases control neural development and function. Dev Growth Differ 36:543-550.
    • (1994) Dev Growth Differ , vol.36 , pp. 543-550
    • Yagi, T.1
  • 32
    • 0033561710 scopus 로고    scopus 로고
    • Molecular mechanisms of fyn-tyrosine kinase for regulating mammalian behaviors and ethanol sensitivity
    • Yagi T (1999) Molecular mechanisms of fyn-tyrosine kinase for regulating mammalian behaviors and ethanol sensitivity. Biochem Pharmacol 57:845-850.
    • (1999) Biochem Pharmacol , vol.57 , pp. 845-850
    • Yagi, T.1
  • 33
    • 0027527791 scopus 로고
    • Regional localization of fyn in adult brain; studies with mice in which the fyn gene was replaced by lac Z
    • Yagi T, Shigetani Y, Okado N, Tokunaga T, Ikawa Y, and Aizawa S (1993) Regional localization of fyn in adult brain; studies with mice in which the fyn gene was replaced by lac Z. Oncogene 8:3343-3351.
    • (1993) Oncogene , vol.8 , pp. 3343-3351
    • Yagi, T.1    Shigetani, Y.2    Okado, N.3    Tokunaga, T.4    Ikawa, Y.5    Aizawa, S.6
  • 34
    • 0037868950 scopus 로고    scopus 로고
    • Scaffolding of fyn kinase to the NMDA receptor determines brain region sensitivity to ethanol
    • Yaka R, Phamluong K, and Ron D (2003) Scaffolding of fyn kinase to the NMDA receptor determines brain region sensitivity to ethanol. J Neurosci 23:3623-3632.
    • (2003) J Neurosci , vol.23 , pp. 3623-3632
    • Yaka, R.1    Phamluong, K.2    Ron, D.3
  • 35
    • 0026615851 scopus 로고
    • A/benzodiazepine receptor β1, β2 and β3 subunit mRNAs in the developing mouse cerebellum
    • A/benzodiazepine receptor β1, β2 and β3 subunit mRNAs in the developing mouse cerebellum. J Comp Neurol 326:580-594.
    • (1992) J Comp Neurol , vol.326 , pp. 580-594
    • Zdilar, D.1    Luntz-Leybman, V.2    Frostholm, A.3    Rotter, A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.