GM-CSF protects rat photoreceptors from death by activating the SRC-dependent signalling and elevating anti-apoptotic factors and neurotrophins

Graefe's Archive for Clinical and Experimental Ophthalmology

Volumn 250, Issue 5, 2012, Pages 699-712

  Schallenberg, Maurice ^a   Charalambous, Petar ^a   Thanos, Solon ^a  

^a UNIVERSITY HOSPITAL MÜNSTER   (Germany)

Author keywords

GM CSF; Neuroprotection; Photoreceptor degeneration; RCS rats; Retina

Indexed keywords

APOPTOTIC PROTEASE ACTIVATING FACTOR 1; BRAIN DERIVED NEUROTROPHIC FACTOR; CILIARY NEUROTROPHIC FACTOR; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; GLIAL FIBRILLARY ACIDIC PROTEIN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN BAD; PROTEIN BCL 2; PROTEIN TYROSINE KINASE; STAT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL COUNT; CELL NUCLEUS; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG MECHANISM; EYE PROTECTION; HISTOPATHOLOGY; INTRACELLULAR SIGNALING; NEUROPROTECTION; NONHUMAN; ONSET AGE; PHOTORECEPTOR; PHOTORECEPTOR DEGENERATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REPEATED DRUG DOSE; RETINA DEGENERATION; SINGLE DRUG DOSE;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; BCL-ASSOCIATED DEATH PROTEIN; BLOTTING, WESTERN; GLIAL FIBRILLARY ACIDIC PROTEIN; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; IMMUNOHISTOCHEMISTRY; INTRAVITREAL INJECTIONS; NERVE GROWTH FACTORS; PHOTORECEPTOR CELLS, VERTEBRATE; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, MUTANT STRAINS; RECEPTORS, GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; RETINAL DEGENERATION; RHODOPSIN; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES; STAT3 TRANSCRIPTION FACTOR;

EID: 84862903620     PISSN: 0721832X     EISSN: 1435702X     Source Type: Journal    
DOI: 10.1007/s00417-012-1932-9     Document Type: Article

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