Pegylated phospholipid micelles induce endoplasmic reticulum-dependent apoptosis of cancer cells but not normal cells

ACS Nano

Volumn 6, Issue 6, 2012, Pages 5018-5030

  Wang, Jing ^a,b   Fang, Xiaocui ^a,b   Liang, Wei ^a  

^a INSTITUTE OF BIOPHYSICS   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

apoptosis; Bcl 2 family protein; biocompatibility; ER stress; micelles; unfolded protein response

Indexed keywords

ANTIAPOPTOTIC; BCL-2 AND BCL-XL; BCL-2 FAMILY PROTEINS; CANCER CELLS; CELL FATES; CELL LINES; CHEMOTHERAPEUTIC AGENTS; DRUG DELIVERY SYSTEM; ENDOPLASMIC RETICULUM; ER STRESS; LIPID DROPLETS; LIPID SYNTHESIS; MOLECULAR MECHANISM; NONIONIC; PHOSPHOETHANOLAMINE; RAPID DEVELOPMENT; STRESS-INDUCED; UNFOLDED PROTEIN RESPONSE;

BIOCOMPATIBILITY; BLOCK COPOLYMERS; CELL CULTURE; CELL DEATH; CELL MEMBRANES; DRUG DELIVERY; MICELLES; NANOSTRUCTURED MATERIALS; PHOSPHOLIPIDS; POLYETHYLENE OXIDES; PROTEINS;

POLYETHYLENE GLYCOLS;

MACROGOL DERIVATIVE; NANOCAPSULE; PHOSPHOLIPID;

APOPTOSIS; ARTICLE; CELL STRAIN HEK293; DRUG EFFECT; ENDOPLASMIC RETICULUM; HUMAN; LUNG TUMOR; MICELLE; PATHOLOGY; TUMOR CELL LINE;

APOPTOSIS; CELL LINE, TUMOR; ENDOPLASMIC RETICULUM; HEK293 CELLS; HUMANS; LUNG NEOPLASMS; MICELLES; NANOCAPSULES; PHOSPHOLIPIDS; POLYETHYLENE GLYCOLS;

EID: 84862886943     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn300571c     Document Type: Article

References (42)

1. Maynard, A. D.; Aitken, R. J.; Butz, T.; Colvin, V.; Donaldson, K.; Oberdorster, G.; Philbert, M. A.; Ryan, J.; Seaton, A.; Stone, V. Safe Handling of Nanotechnology Nature 2006, 444, 267-269
2. Nel, A.; Xia, T.; Madler, L.; Li, N. Toxic Potential of Materials at the Nanolevel Science 2006, 311, 622-627
3. Singh, N.; Manshian, B.; Jenkins, G. J.; Griffiths, S. M.; Williams, P. M.; Maffeis, T. G.; Wright, C. J.; Doak, S. H. Nanogenotoxicology: The DNA Damaging Potential of Engineered Nanomaterials Biomaterials 2009, 30, 3891-3914
4. Aillon, K. L.; Xie, Y.; El-Gendy, N.; Berkland, C. J.; Forrest, M. L. Effects of Nanomaterial Physicochemical Properties on in vivo Toxicity Adv. Drug Delivery Rev. 2009, 61, 457-466
5. Jain, K.; Kesharwani, P.; Gupta, U.; Jain, N. K. Dendrimer Toxicity: Let's Meet the Challenge Int. J. Pharm. 2010, 394, 122-142
6. Wang, X.; Kan, B.; Wang, Y.; Dong, P.; Shi, S.; Guo, G.; Zhao, Y.; Luo, F.; Zhao, X.; Wei, Y.; Qian, Z. Safety Evaluation of Amphiphilic Three-Armed Star-Shaped Copolymer Micelles J. Pharm. Sci. 2010, 99, 2830-2838
7. Lavasanifar, A.; Samuel, J.; Kwon, G. S. Poly(ethylene oxide)- block -Poly(l -amino acid) Micelles for Drug Delivery Adv. Drug Delivery Rev. 2002, 54, 169-190
8. Torchilin, V. P. Micellar Nanocarriers: Pharmaceutical Perspectives Pharm. Res. 2007, 24, 1-16
9. Tang, N.; Du, G.; Wang, N.; Liu, C.; Hang, H.; Liang, W. Improving Penetration in Tumors with Nanoassemblies of Phospholipids and Doxorubicin J. Natl. Cancer Inst. 2007, 99, 1004-1015
10. Wang, J.; Wang, Y.; Liang, W. Delivery of Drugs to Membreanes by Encapsulation in PEG-PE Micelles. J. Controlled Release 2012, in press, doi: 10.1016/j.jconrel.2012.02.021.
11. Kim, I.; Xu, W.; Reed, J. C. Cell Death and Endoplasmic Reticulum Stress: Disease Relevance and Therapeutic Opportunities Nat. Rev. Drug Discovery 2008, 7, 1013-1030
12. Feng, B.; Yao, P. M.; Li, Y.; Devlin, C. M.; Zhang, D.; Harding, H. P.; Sweeney, M.; Rong, J. X.; Kuriakose, G.; Fisher, E. A. The Endoplasmic Reticulum is the Site of Cholesterol-Induced Cytotoxicity in Macrophages Nat. Cell Biol. 2003, 5, 781-792
13. Pineau, L.; Colas, J.; Dupont, S.; Beney, L.; Fleurat-Lessard, P.; Berjeaud, J. M.; Berges, T.; Ferreira, T. Lipid-Induced ER Stress: Synergistic Effects of Sterols and Saturated Fatty Acids Traffic 2009, 10, 673-690
14. Huth, U. S.; Schubert, R.; Peschka-Suss, R. Investigating the Uptake and Intracellular Fate of pH-Sensitive Liposomes by Flow Cytometry and Spectral Bio-Imaging J. Controlled Release 2006, 110, 490-504
15. Borradaile, N. M.; Han, X.; Harp, J. D.; Gale, S. E.; Ory, D. S.; Schaffer, J. E. Disruption of Endoplasmic Reticulum Structure and Integrity in Lipotoxic Cell Death J. Lipid Res. 2006, 47, 2726-2737
16. Ron, D.; Walter, P. Signal Integration in the Endoplasmic Reticulum Unfolded Protein Response Nat. Rev. Mol. Cell Biol. 2007, 8, 519-529
17. Szegezdi, E.; Logue, S. E.; Gorman, A. M.; Samali, A. Mediators of Endoplasmic Reticulum Stress-Induced Apoptosis EMBO Rep. 2006, 7, 880-885
18. Novoa, I.; Zeng, H.; Harding, H. P.; Ron, D. Feedback Inhibition of the Unfolded Protein Response by GADD34-Mediated Dephosphorylation of eIF2α J. Cell Biol. 2001, 153, 1011-1021
19. Horton, J. D.; Goldstein, J. L.; Brown, M. S. SREBPs: Activators of the Complete Program of Cholesterol and Fatty Acid Synthesis in the Liver J. Clin. Invest. 2002, 109, 1125-1131
20. Colgan, S. M.; Tang, D.; Werstuck, G. H.; Austin, R. C. Endoplasmic Reticulum Stress Causes the Activation of Sterol Regulatory Element Binding Protein-2 Int. J. Biochem. Cell Biol. 2007, 39, 1843-1851
21. Welch, W. J.; Brown, C. R. Influence of Molecular and Chemical Chaperones on Protein Folding Cell Stress Chaperones 1996, 1, 109-115
22. McCullough, K. D.; Martindale, J. L.; Klotz, L. O.; Aw, T. Y.; Holbrook, N. J. Gadd153 Sensitizes Cells to Endoplasmic Reticulum Stress by Down-regulating Bcl2 and Perturbing the Cellular Redox State Mol. Cell. Biol. 2001, 21, 1249-1259
23. Boyce, M.; Yuan, J. Cellular Response to Endoplasmic Reticulum Stress: A Matter of Life or Death Cell Death Differ. 2006, 13, 363-373
24. Kepp, O.; Galluzzi, L.; Lipinski, M.; Yuan, J.; Kroemer, G. Cell Death Assays for Drug Discovery Nat. Rev. Drug Discovery 2011, 10, 221-237
25. Szegezdi, E.; Macdonald, D. C.; Ni-Chonghaile, T.; Gupta, S.; Samali, A. Bcl-2 Family on Guard at the ER Am. J. Physiol.: Cell Physiol. 2009, 296, C941-953
26. Wei, M. C.; Zong, W. X.; Cheng, E. H.; Lindsten, T.; Panoutsakopoulou, V.; Ross, A. J.; Roth, K. A.; MacGregor, G. R.; Thompson, C. B.; Korsmeyer, S. J. Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death Science 2001, 292, 727-730
27. Willis, S. N.; Chen, L.; Dewson, G.; Wei, A.; Naik, E.; Fletcher, J. I.; Adams, J. M.; Huang, D. C. Proapoptotic Bak Is Sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, Until Displaced by BH3-Only Proteins Genes Dev. 2005, 19, 1294-1305
28. 2+ Stores J. Biol. Chem. 2002, 277, 9219-9225
29. Wei, M. C.; Lindsten, T.; Mootha, V. K.; Weiler, S.; Gross, A.; Ashiya, M.; Thompson, C. B.; Korsmeyer, S. J. tBID, a Membrane-Targeted Death Ligand, Oligomerizes BAK to Release Cytochrome c Genes Dev. 2000, 14, 2060-2071
30. Zinszner, H.; Kuroda, M.; Wang, X.; Batchvarova, N.; Lightfoot, R. T.; Remotti, H.; Stevens, J. L.; Ron, D. CHOP Is Implicated in Programmed Cell Death in Response to Impaired Function of the Endoplasmic Reticulum Genes Dev. 1998, 12, 982-995
31. Li, Y.; Ge, M.; Ciani, L.; Kuriakose, G.; Westover, E. J.; Dura, M.; Covey, D. F.; Freed, J. H.; Maxfield, F. R.; Lytton, J.; Tabas, I. Enrichment of Endoplasmic Reticulum with Cholesterol Inhibits Sarcoplasmic-Endoplasmic Reticulum Calcium ATPase-2b Activity in Parallel with Increased Order of Membrane Lipids: Implications for Depletion of Endoplasmic Reticulum Calcium Stores and Apoptosis in Cholesterol-Loaded Macrophages J. Biol. Chem. 2004, 279, 37030-37039
32. van der Sanden, M. H.; Houweling, M.; van Golde, L. M.; Vaandrager, A. B. Inhibition of Phosphatidylcholine Synthesis Induces Expression of the Endoplasmic Reticulum Stress and Apoptosis-Related Protein CCAAT/Enhancer- Binding Protein-Homologous Protein (CHOP/GADD153) Biochem. J. 2003, 369, 643-650
33. Przybytkowski, E.; Behrendt, M.; Dubois, D.; Maysinger, D. Nanoparticles Can Induce Changes in the Intracellular Metabolism of Lipids without Compromising Cellular Viability FEBS J. 2009, 276, 6204-6217
34. 2+, Leading to Induction of Endoplasmic Reticulum Stress in Pancreatic Beta-Cells Diabetes 2005, 54, 452-461
35. Jeanson, L.; Kelly, M.; Coste, A.; Guerrera, I. C.; Fritsch, J.; Nguyen-Khoa, T.; Baudouin-Legros, M.; Papon, J. F.; Zadigue, P.; Prulière-Escabasse, V. Oxidative Stress Induces Unfolding Protein Response and Inflammation in Nasal Polyposis Allergy 2012, 67, 403-412
36. Pizzo, P.; Pozzan, T. Mitochondria-Endoplasmic Reticulum Choreography: Structure and Signaling Dynamics Trends Cell Biol. 2007, 17, 511-517
37. Görlach, A.; Klappa, P.; Kietzmann, T. The Endoplasmic Reticulum: Folding, Calcium Homeostasis, Signaling, and Redox Control Antioxid. Redox Signaling 2006, 8, 1391-1418
38. Wang, G.; Yang, Z. Q.; Zhang, K. Endoplasmic Reticulum Stress Response in Cancer: Molecular Mechanism and Therapeutic Potential Am. J. Transl. Res. 2010, 2, 65-74
39. Koumenis, C. ER Stress, Hypoxia Tolerance and Tumor Progression Curr. Mol. Med. 2006, 6, 55-69
40. Flavin, R.; Zadra, G.; Loda, M. Metabolic Alterations and Targeted Therapies in Prostate Cancer J. Pathol. 2011, 223, 283-294
41. Zong, W. X.; Li, C.; Hatzivassiliou, G.; Lindsten, T.; Yu, Q. C.; Yuan, J.; Thompson, C. B. Bax and Bak Can Localize To the Endoplasmic Reticulum to Initiate Apoptosis J. Cell Biol. 2003, 162, 59-69
42. Healy, S. J.; Gorman, A. M.; Mousavi-Shafaei, P.; Gupta, S.; Samali, A. Targeting the Endoplasmic Reticulum-Stress Response as An Anticancer Strategy Eur. J. Pharmacol. 2009, 625, 234-246