Hybrids of a genetically engineered antibody and a carbon nanotube transistor for detection of prostate cancer biomarkers

ACS Nano

Volumn 6, Issue 6, 2012, Pages 5143-5149

  Lerner, Mitchell B ^a   D'Souza, Jimson ^b   Pazina, Tatiana ^b   Dailey, Jennifer ^a   Goldsmith, Brett R ^a   Robinson, Matthew K ^b   Johnson, A T Charlie ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b FOX CHASE CANCER CENTER   (United States)

Author keywords

biosensor; cancer diagnostics; carbon nanotube; field effect transistor

Indexed keywords

A-CARBON; AMINE GROUPS; BINDING AFFINITIES; BIOLOGICAL BINDING; BOVINE SERUM ALBUMINS; CANCER DIAGNOSTICS; CHEMICAL FUNCTIONALIZATION; COMPLEMENTARY PROTEINS; CONCENTRATION-DEPENDENT; DEFECT SITES; DETECTION LIMITS; DETECTION MECHANISM; DETECTION METHODS; DIAZONIUM SALTS; ELECTRON TRANSPORT MEASUREMENTS; FUNCTIONALIZATIONS; FUNCTIONALIZED; HYBRID DEVICES; LOSS-OF-SIGNAL; OSTEOPONTIN; PROSTATE CANCERS; SINGLE CHAIN VARIABLE FRAGMENTS; SOURCE-DRAIN CURRENT;

ANTIBODIES; ATOMIC FORCE MICROSCOPY; BINDING ENERGY; BINDING SITES; BIOMARKERS; BIOSENSORS; CARBON NANOTUBES; DISEASES; FIELD EFFECT TRANSISTORS; GENETIC ENGINEERING;

CHEMICAL DETECTION;

ANTIBODY; CARBON NANOTUBE; OSTEOPONTIN; TUMOR MARKER;

ANIMAL; ARTICLE; BLOOD; CATTLE; CHEMISTRY; CONDUCTOMETRY; EQUIPMENT; EQUIPMENT DESIGN; GENETICS; HUMAN; IMMUNOASSAY; INSTRUMENTATION; MALE; METHODOLOGY; PROSTATE TUMOR; PROTEIN ENGINEERING; SEMICONDUCTOR; ULTRASTRUCTURE;

ANIMALS; ANTIBODIES; CATTLE; CONDUCTOMETRY; EQUIPMENT DESIGN; EQUIPMENT FAILURE ANALYSIS; HUMANS; IMMUNOASSAY; MALE; NANOTUBES, CARBON; OSTEOPONTIN; PROSTATIC NEOPLASMS; PROTEIN ENGINEERING; TRANSISTORS, ELECTRONIC; TUMOR MARKERS, BIOLOGICAL;

EID: 84862872330     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn300819s     Document Type: Article

References (39)

1. Group, U.S.C.S.W. United States Cancer Statistics: 1999-2007 Incidence and Mortality Web-Based Report. U.S. Department of Health and Human Services, C.f.D.C.a.P.a.N.C.I., Ed.; Atlanta, GA, 2010.
2. Smith, D. S.; Humphrey, P. A.; Catalona, W. J. The Early Detection of Prostate Carcinoma with Prostate Specific Antigen-The Washington University Experience Cancer 1997, 80, 1852-1856
3. Fedarko, N. S.; Jain, A.; Karadag, A.; Van Eman, M. R.; Fisher, L. W. Elevated Serum Bone Sialoprotein and Osteopontin in Colon, Breast, Prostate, and Lung Cancer Clin. Cancer Res. 2001, 7, 4060-4066
4. Sodek, J.; Ganss, B.; McKee, M. D. Osteoponitn Crit. Rev. Oral Biol. Med. 2000, 11, 279-303
5. Morimoto, J.; Kon, S.; Matsui, Y.; Uede, T. Osteopontin as a Target Molecule for the Treatment of Inflammatory Diseases Curr. Drug Targets 2010, 11, 494-505
6. Bellahcene, A.; Castronovo, V.; Ogbureke, K. U.; Fisher, L. W.; Fedarko, N. S. Small Integrin-Binding Ligand N-Linked Glycoproteins (Siblings): Multifunctional Proteins in Cancer Nat. Rev. Cancer 2008, 8, 212-226
7. Hotte, S. J.; Winquist, E. W.; Stitt, L.; Wilson, S. M.; Chambers, A. F. Plasma Osteopontin: Associations with Survival and Metastasis to Bone in Men with Hormone-Refractory Prostate Carcinoma Cancer 2002, 95, 506-512
8. Fan, K.; Dai, J.; Wang, H.; Wei, H.; Cao, Z.; Hou, S.; Qian, W.; Li, B.; Zhao, J.; Xu, H. et al. Treatment of Collagen-Induced Arthritis with an Anti-Osteopontin Monoclonal Antibody through Promotion of Apoptosis of Both Murine and Human Activated T Cells Arthritis Rheum. 2008, 58, 2041-2052
9. Anborgh, P. H.; Wilson, S. M.; Tuck, A. B.; Winquist, E.; Schmidt, N.; Hart, R.; Kon, S.; Maeda, M.; Uede, T.; Stitt, L. W. et al. New Dual Monoclonal Elisa for Measuring Plasma Osteopontin as a Biomarker Associated with Survival in Prostate Cancer: Clinical Validation and Comparison of Multiple Elisas Clin. Chem. 2009, 55, 895-903
10. Plumer, A.; Duan, H.; Subramaniam, S.; Lucas, F. L.; Miesfeldt, S.; Ng, A. K.; Liaw, L. Development of Fragment-Specific Osteopontin Antibodies and Elisa for Quantification in Human Metastatic Breast Cancer BMC Cancer 2008, 8, 38
11. Ward, A. M.; Catto, J. W.; Hamdy, F. C. Prostate Specific Antigen: Biology, Biochemistry and Available Commercial Assays Ann. Clin. Biochem. 2001, 38, 633-651
12. Gao, X.; Zheng, G.; Lieber, C. M. Subthreshold Regime Has the Optimal Sensitivity for Nanowire Fet Sensors Nano Lett. 2010, 10, 547-552
13. Chen, R. J.; Choi, H. C.; Bangsaruntip, S.; Yenilmez, E.; Tang, X. W.; Wang, Q.; Chang, Y. L.; Dai, H. J. An Investigation of the Mechanisms of Electronic Sensing of Protein Adsorption on Carbon Nanotube Devices J. Am. Chem. Soc. 2004, 126, 1563-1568
14. Staii, C.; Chen, M.; Gelperin, A.; Johnson, A. T. DNA-Decorated Carbon Nanotubes for Chemical Sensing Nano Lett. 2005, 5, 1774-1778
15. Allen, B. L.; Kichambare, P. D.; Star, A. Carbon Nanotube Field-Effect-Transistor-Based Biosensors Adv. Mater. 2007, 19, 1439-1451
16. Heller, I.; Janssens, A. M.; Mannik, J.; Minot, E. D.; Lemay, S. G.; Dekker, C. Identifying the Mechanism of Biosensing with Carbon Nanotube Transistors Nano Lett. 2008, 8, 591-595
17. Star, A.; Gabriel, J. C. P.; Bradley, K.; Gruner, G. Electronic Detection of Specific Protein Binding Using Nanotube FET Devices Nano Lett. 2003, 3, 459-463
18. Kuang, Z. F.; Kim, S. N.; Crookes-Goodson, W. J.; Farmer, B. L.; Naik, R. R. Biomimetic Chemosensor: Designing Peptide Recognition Elements for Surface Functionalization of Carbon Nanotube Field Effect Transistors ACS Nano 2010, 4, 452-458
19. So, H. M.; Park, D. W.; Jeon, E. K.; Kim, Y. H.; Kim, B. S.; Lee, C. K.; Choi, S. Y.; Kim, S. C.; Chang, H.; Lee, J. O. Detection and Titer Estimation of Escherichia Coli Using Aptamer-Functionalized Single-Walled Carbon-Nanotube Field-Effect Transistors Small 2008, 4, 197-201
20. Goldsmith, B. R.; Mitala, J. J.; Josue, J.; Castro, A.; Lerner, M. B.; Bayburt, T. H.; Khamis, S. M.; Jones, R. A.; Brand, J. G.; Sligar, S. G. et al. Biomimetic Chemical Sensors Using Nanoelectronic Readout of Olfactory Receptor Proteins ACS Nano 2011, 5, 5408-5416
21. Kim, S. N.; Rusling, J. F.; Papadimitrakopoulos, F. Carbon Nanotubes for Electronic and Electrochemical Detection of Biomolecules Adv. Mater. 2007, 19, 3214-3228
22. Cao, Q.; Rogers, J. A. Ultrathin Films of Single-Walled Carbon Nanotubes for Electronics and Sensors: A Review of Fundamental and Applied Aspects Adv. Mater. 2009, 21, 29-53
23. Sanchez, S.; Fabregas, E.; Pumera, M. Detection of Biomarkers with Carbon Nanotube-Based Immunosensors Methods Mol. Biol. 2010, 625, 227-237
24. Fan, K.; Zhang, B.; Yang, H.; Wang, H.; Tan, M.; Hou, S.; Qian, W.; Li, B.; Wang, H.; Dai, J. et al. A Humanized Anti-Osteopontin Antibody Protects from Concanavalin a Induced-Liver Injury in Mice Eur. J. Pharmacol. 2011, 657, 144-151
25. Holliger, P.; P.J., H. Engineered Antibody Fragments and the Rise of Single Domains Nat. Biotechnol. 2005, 23, 1126-1136
26. Khamis, S. M.; Jones, R. A.; Johnson, A. T. C. Optimized Photolithographic Fabrication Process for Carbon Nanotube Devices AIP Adv. 2011, 1, 022106
27. Strano, M. S.; Dyke, C. A.; Usrey, M. L.; Barone, P. W.; Allen, M. J.; Shan, H. W.; Kittrell, C.; Hauge, R. H.; Tour, J. M.; Smalley, R. E. Electronic Structure Control of Single-Walled Carbon Nanotube Functionalization Science 2003, 301, 1519-1522
28. Lu, Y.; Lerner, M. B.; Qi, Z. J.; Mitala, J. J.; Lim, J. H.; Discher, B. M.; Johnson, A. T. C. Graphene-Protein Bioelectronic Devices with Wavelength-Tunable Photoresponse Appl. Phys. Lett. 2012, 100, 033110
29. Du, J.; Hou, S.; Zhong, C.; Lai, Z.; Yang, H.; Dai, J.; Zhang, D.; Wang, H.; Guo, Y.; Ding, J. Molecular Basis of Recognition of Human Osteopontin by 23c3, a Potential Therapeutic Antibody for Treatment of Rheumatoid Arthritis J. Mol. Biol. 2008, 382, 835-842
30. Squires, T. M.; Messinger, R. J.; Manalis, S. R. Making It Stick: Convection Reaction and Diffusion in Surface-Based Biosensors Nat. Biotechnol. 2008, 26, 417-426
31. Arlett, J. L.; Myers, E. B.; Roukes, M. L. Comparative Advantages of Mechanical Biosensors Nat. Nanotechnol. 2011, 6, 203-215
32. Hill, A. The Possible Effects of the Aggregation of the Molecules of Hemoglobin on Its Oxygen Dissociation Curve J. Physiol. 1910, 40, 4-7
33. Butler, W. T.; Ridall, A. L.; McKee, M. D. Osteopontin. In Principals of Bone Biology; Bilezikian, J. P.; Raisz, L. G.; Rodan, G. A., Eds.; Academic Press: New York, 1996; pp 167-181.
34. Slamon, D. J.; Leyland-Jones, B.; Shak, S.; Fuchs, H.; Paton, V.; Bajamonde, A.; Fleming, T.; Eiermann, W.; Wolter, J.; Pegram, M. et al. Use of Chemotherapy Plus a Monoclonal Antibody against Her2 for Metastatic Breast Cancer That Overexpresses Her2 N. Engl. J. Med. 2001, 344, 783-792
35. Worn, A.; Pluckthun, A. An Intrinsically Stable Antibody Scfv Fragment Can Tolerate the Loss of Both Disulfide Bonds and Fold Correctly FEBS Lett. 1998, 427, 357-361
36. MacBeath, G. Protein Microarrays and Proteomics Nat. Genet. 2002, 32, 526-532
37. Robinson, M. K.; Hodge, K. M.; Horak, E.; Sundberg, A. L.; Russeva, M.; Shaller, C. C.; von Mehren, M.; Shchaveleva, I.; Simmons, H. H.; Marks, J. D. et al. Targeting Erbb2 and Erbb3 with a Bispecific Single-Chain Fv Enhances Targeting Selectivity and Induces a Therapeutic Effect in Vitro Br. J. Cancer 2008, 99, 1415-1425
38. Kubetzko, S.; Balic, E.; Wiaibel, R.; Zangemeister-Wittke, U.; Pluckthun, A. Pegylation and Multimerization of the Anti-P185 Her-2 Single Chain Fv Fragment 4d5 J. Biol. Chem. 2006, 281, 35186-35201
39. Saby, C.; Ortiz, B.; Champagne, G. Y.; Belanger, D. Electrochemical Modification of Glassy Carbon Electrode Using Aromatic Diazonium Salts 0.1. Blocking Effect of 4-Nitrophenyl and 4-Carboxyphenyl Groups Langmuir 1997, 13, 6805-6813