Phospho-Rb mediating cell cycle reentry induces early apoptosis following oxygen-glucose deprivation in rat cortical neurons

Neurochemical Research

Volumn 37, Issue 3, 2012, Pages 503-511

  Yu, Ying ^a   Ren, Qing Guo ^b   Zhang, Zhao Hui ^a   Zhou, Ke ^a   Yu, Zhi Yuan ^c   Luo, Xiang ^c   Wang, Wei ^c  

^a RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

^b AFFILIATED ZHONGDA HOSPITAL OF SOUTHEAST UNIVERSITY   (China)

^c HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Cell cycle reentry; Early apoptosis; Neuron; Oxygen Glucose deprivation; Phospho Rb

Indexed keywords

BROXURIDINE; GLUCOSE; OXYGEN; RETINOBLASTOMA BINDING PROTEIN; ROSCOVITINE;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; BRAIN CELL; CELL ACTIVITY; CELL CYCLE; CELL FUNCTION; CELL HYPOXIA; CELLULAR DISTRIBUTION; IN VITRO STUDY; ISCHEMIA; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CELL CYCLE; CEREBRAL CORTEX; FLOW CYTOMETRY; GLUCOSE; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; NEURONS; OXYGEN; PHOSPHORYLATION; RATS; RETINOBLASTOMA PROTEIN;

RATTUS;

EID: 84862869411     PISSN: 03643190     EISSN: 15736903     Source Type: Journal    
DOI: 10.1007/s11064-011-0636-6     Document Type: Article

References (35)

1. Okano HJ, Pfaff DW, Gibbs RB (1993) RB and Cdc2 expression in brain: correlations with 3H-thymidine incorporation and neurogenesis. J Neurosci 13:2930-2938 (Pubitemid 23199220)
2. Nguyen MD, Mushynski WE, Julien JP (2002) Cycling at the interface between neurodevelopment and neurodegeneration. Cell Death Differ 9:1294-1306 (Pubitemid 36097699)
3. Wartiovaara K, Barnabe-Heider F, Miller FD et al (2002) N-myc promotes survival and induces S-phase entry of postmitotic sympathetic neurons. J Neurosci 22:815-824 (Pubitemid 34141762)
4. Osuga H, Osuga S, Wang F et al (2000) Cyclin-dependent kinases as a therapeutic target for stroke. Proc Natl Acad Sci USA 97:10254-10259
5. Wen Y, Yang S, Liu R et al (2005) Cell-cycle regulators are involved in transient cerebral ischemia induced neuronal apoptosis in female rats. FEBS Lett 79:4591-4599 (Pubitemid 41218632)
6. Kuan CY, Schloemer AJ, Lu A et al (2004) Hypoxia-ischemia induces DNA synthesis without cell proliferation in dying neurons in adult rodent brain. J Neurosci 24:10763-10772 (Pubitemid 39557651)
7. Vermeulen K, Berneman ZN, Van Bockstaele DR (2003) Cell cycle and apoptosis. Cell Prolif 36:165-175 (Pubitemid 36808272)
8. Liu DX, Greene LA (2001) Neuronal apoptosis at the G1/S cell cycle checkpoint. Cell Tissue Res 305:217-228 (Pubitemid 32681898)
9. Weinberg RA (1995) The retinoblastoma protein and cell cycle control. Cell 81:323-330
10. Dimova DK, Dyson NJ (2005) The E2F transcriptional network: old acquaintances with new faces. Oncogene 24:2810-2826 (Pubitemid 40638092)
11. Balciunaite E, Spektor A, Lents NH et al (2005) Pocket protein complexes are recruited to distinct targets in quiescent and proliferating cells. Mol Cell Biol 25:8166-8178 (Pubitemid 41263008)
12. Greene LA, Liu DX, Troy CM et al (2007) Cell cycle molecules define a pathway required for neuron death in development and disease. Biochim Biophys Acta 1772:392-401 (Pubitemid 46400389)
13. Lee EY, Hu N, Yuan SS et al (1994) Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation. Genes Dev 8:2008-2021 (Pubitemid 24280849)
14. Hayashi T, Sakai K, Sasaki C et al (2000) Phosphorylation of retinoblastoma protein in rat brain after transient middle cerebral artery occlusion. Neuropathol Appl Neurobiol 26:390-397 (Pubitemid 30609435)
15. Rashidian J, Iyirhiaro G, Aleyasin H et al (2005) Multiple cyclindependent kinases signals are critical mediators of ischemia/ hypoxic neuronal death in vitro and in vivo. Proc Natl Acad Sci USA 102:14080-14085 (Pubitemid 41377706)
16. Yu Y, Luo X, Ren QG et al (2009) The involvement of upregulation and translocation of phospho-Rb in early neuronal apoptosis following focal cerebral ischemia in rats. Neurochem Res 34:1113-1119
17. Lossi L, Merighi A (2003) In vivo cellular and molecular mechanisms of neuronal apoptosis in the mammalian CNS. Prog Neurobiol 69:287-312 (Pubitemid 36645051)
18. Gwag BJ, Lobner D, Koh JY et al (1995) Blockade of glutamate receptors unmasks neuronal apoptosis after oxygen glucose deprivation in vitro. Neuroscience 68:615-619
19. Gong QH, Wang Q, Shi JS et al (2007) Inhibition of caspases and intracellular free Ca2+ concentrations are involved in resveratrol protection against apoptosis in rat primary neuron cultures. Acta Pharmacol Sin 28:1724-1730 (Pubitemid 350029331)
20. Lin SH, Vincent A, Shaw T et al (2000) Prevention of nitric oxide-induced neuronal injury through the modulation of independent pathways of programmed cell death. J Cereb Blood Flow Metab 20:1380-1391
21. Maiese K, Vincent AM (2000) Membrane asymmetry and DNA degradation: functionally distinct determinants of neuronal programmed cell death. J Neurosci Res 59:568-580 (Pubitemid 30090585)
22. Connell-Crowley L, Harper JWGoodrich DW (1997) Cyclin D1/Cdk 4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation. Mol Biol Cell 8:287-301 (Pubitemid 27097944)
23. Pan W, Sun T, Hoess R et al (1998) Defining the minimal portion of the retinoblastoma protein that serves as an efficient substrate for cdk4 kinase/cyclin D1 complex. Carcinogenesis 19:765-769 (Pubitemid 28376765)
24. Kitagawa M, Higashi H, Jung HK et al (1996) The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclinA/E-Cdk2. EMBO J 15:7060-7069 (Pubitemid 27023276)
25. Ranganathan S, Bowser R (2003) Alterations in G(1) to S phase cell-cycle regulators during amyotrophic lateral sclerosis. Am J Pathol 162:823-835 (Pubitemid 36237491)
26. Meijer L, Raymond E (2003) Roscovitine and other purines as kinase inhibitors: From starfish oocytes to clinical trials. Acc Chem Res 36:417-425
27. Byrnes KR, Faden AI (2007) Role of cell cycle proteins in CNS injury. Neurochem Res 32:1799-1807 (Pubitemid 47428847)
28. Dick FA, Dyson N (2003) pRB contains an E2F1-specific binding domain that allows E2F1-induced apoptosis to be regulated separately from other E2F activities. Mol Cell 12:639-649 (Pubitemid 37229084)
29. Denchi EL, Helin K (2005) E2F1 is crucial for E2F-dependent apoptosis. EMBO Rep 6:661-668
30. Nguyen MD, Boudreau M, Kriz J et al (2003) Cell cycle regulators in the neuronal death pathway of amyotrophic lateral sclerosis caused by mutant superoxide dismutase 1. J Neurosci 23:2131-2140 (Pubitemid 36368901)
31. Park DS, Obeidat A, Giovanni A et al (2000) Cell cycle regulators in neuronal death evoked by excitotoxic stress: implications for neurodegeneration and its treatment. Neurobiol Aging 21:771-781
32. Jordan-Sciutto KL, Malaiyandi LM, Bowser R (2002) Altered distribution of cell cycle transcriptional regulators during Alzheimer disease. J Neuropathol Exp Neurol 61:358-367 (Pubitemid 34266787)
33. Panickar KS, Nonner D, White MG et al (2008) Overexpression of Cdk5 or non-phosphorylatable retinoblastoma protein protects septal neurons from oxygen-glucose deprivation. Neurochem Res 33:1852-1858
34. Wang W, Redecker C, Bidmon HJ et al (2004) Delayed neuronal death and damage of GDNF family receptors in CA1 following focal cerebral ischemia. Brain Res 1023:92-101 (Pubitemid 39195338)
35. Cho BB, Toledo-Pereyra LH (2008) Caspase-independent programmed cell death following ischemic stroke. J Invest Surg 21:141-147 (Pubitemid 351935711)