Dominant lethal mutations of topoisomerase II inhibitors etoposide and merbarone in male mice: A mechanistic study

Archives of Toxicology

Volumn 86, Issue 5, 2012, Pages 725-731

  Attia, Sabry M ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Chemotherapy; Mutagenicity; Reactive oxygen species; Topoisomerase II

Indexed keywords

ACETYLCYSTEINE; DICHLOROFLUORESCEIN; ETOPOSIDE; GYRASE INHIBITOR; MERBARONE; REACTIVE OXYGEN METABOLITE;

ANIMAL EXPERIMENT; ARTICLE; CHEMICAL MUTAGENESIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; FEMALE; LETHALITY; MALE; MOUSE; MUTAGENIC ACTIVITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; SPERMATID;

ACETYLCYSTEINE; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ETOPOSIDE; FEMALE; FLUORESCEINS; MALE; MICE; MUTAGENICITY TESTS; MUTAGENS; MUTATION; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; SPERMATIDS; THIOBARBITURATES; TOPOISOMERASE II INHIBITORS;

ANIMALIA; MUS;

EID: 84862858737     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-011-0799-6     Document Type: Article

References (31)

1. Adler ID (1996) Comparison of the duration of spermatogenesis between male rodents and humans. Mutat Res 352:169-172
2. Albertini S, Chetelat AA, Miller B, Muster W, Pujadas E, Strobel R, Gocke E (1995) Genotoxicity of 17 gyrase- and four mammalian topoisomerase II-poisons in prokaryotic and eukaryotic test systems. Mutagenesis 10(4):343-351
3. Ashby J, Clapp MJL (1995) The rodent dominant lethal assay: a proposed format for data presentation that alerts to pseudo dominant lethal eVects. Mutat Res 330:209-218
4. Attia SM (2008) Mutagenicity of some topoisomerase II-interactive agents. SPJ 17(1):1-24
5. Attia SM (2010) Deleterious eVects of reactive metabolites. Oxid Med Cell Longev 3(4):238-253
6. Attia SM, Schmid TE, Badary OA, Hamada FM, Adler ID (2002) Molecular cytogenetic analysis in mouse sperm of chemically induced aneuploidy: studies with topoisomerase II inhibitors. Mutat Res 520(1-2):1-13
7. Attia SM, Kliesch U, Schriever-Schwemmer G, Badary OA, Hamada FM, Adler ID (2003) Etoposide and merbarone are clastogenic and aneugenic in the mouse bone marrow micronucleus test complemented by Xuorescence in situ hybridization with the mouse minor satellite DNA probe. Environ Mol Mutagen 41(2):99-103
8. Attia SM, Al-Anteet AA, AL-Rasheed NM, Alhaider AA, Al-Harbi MM (2009) Protection of mouse bone marrow from etoposideinduced genomic damage by dexrazoxane. Cancer Chemother Pharmacol 64(4):837-845
9. Bakheet SA, Attia SM (2011) Evaluation of chromosomal instability in diabetic rats treated with naringin. Oxid Med Cell Longev 2011:365292. doi:10.1155/2011/365292
10. Bakheet SA, Attia SM, AL-Rasheed NM, Al-harbi MM, Ashour AE, Korashy HM, Abd-Allah AR, Saquib Q, Al-Khedhairy AA, Musarrat J (2011) Salubrious eVects of dexrazoxane against teniposide-induced DNA damage and programmed cell death in murine marrow cells. Mutagenesis 26(4):533-543
11. Burden DA, OsheroV N (1998) Mechanism of action of eukaryotic topoisomerase II and drugs targeted to the enzyme. Biochim Biophys Acta 1400:139-154
12. Chamorro G, Vega F, Madrigal E, Mercado E, Salazar M (2003) Germ cell mutagenicity of gamma-ethyl-gamma-phenyl-butyrolactone (EPBL) detected in the CF1 mouse-dominant lethal study. Toxicol Lett 142(1-2):37-43
13. Chen M, Beck WT (1995) DiVerences in inhibition of chromosome separation and G2 arrest by DNA topoisomerase II inhibitors merbarone and VM-26. Cancer Res 55:1509-1516
14. D'Agostini F, Bagnasco M, Giunciuglio D, Albini A, De Flora S (1998) Inhibition by oral N-acetylcysteine of doxorubicin-induced clastogenicity and alopecia, and prevention of primary tumors and lung micrometastases in mice. Int J Oncol 13(2):217-224
15. Drake FH, Hofmann GA, Mong SM, Bartus JO, Hertzberg RP, Johnson RK, Mattern MR, Mirabelli CK (1989) In vitro and intracellular inhibition of topoisomerase II by the antitumor agent merbarone. Cancer Res 49(10):2578-2583
16. Ehling UH, Machemer L, Buselmaier W, DÝcka J, Frohberg H, Kratochvilova J, Lang R, Lorke D, Müller D, Peh J, Röthrborn G, Roll R, Schulze-Schencking M, Wiemann H (1978) Standard protocol for the dominant lethal test on male mice. Arch Toxicol 39:173-185
17. Haim N, Roman J, Nemec J, Sinha BK (1986) Peroxidative free radical formation and O-demethylation of etoposide (VP-16) and teniposide (VM-26). Biochem Biophys Res Commun 135:215-220
18. Jha AM, Bharti MK (2002) Mutagenic proWles of carbazole in the male germ cells of Swiss albino mice. Mutat Res 500(1-2):97-101
19. Kagan VE, Yalowich JC, Borisenko GG, Tyurina YY, Tyurin VA, Thampatty P, Fabisiak JP (1999) Mechanism based chemopreventive strategies against etoposide-induced acute myeloid leukemia: free radical/antioxidant approach. Mol Pharmacol 56:494-506
20. Kallio M, Lähdetie J (1996) Fragmentation of centromeric DNA and prevention of homologous chromosome separation in male mouse meiosis in vivo by the topoisomerase II inhibitor etoposide. Mutagenesis 11:435-443
21. Kallio M, Lähdetie J (1997) EVects of the DNA topoisomerase II inhibitor merbarone in male mouse meiotic divisions in vivo: cell cycle arrest and induction of aneuploidy. Environ Mol Mutagen 29:16-27
22. Larsen AK, Escargueil AE, Skladanowski A (2003) Catalytic topoisomerase II inhibitors in cancer therapy. Pharmacol Ther 99(2):167-181
23. Lozzio BB, Lozzio CB (1979) Properties and usefulness of the original K562 human myelogenous leukemia cell line. Leuk Res 3:363-370
24. Mailhes JB, Marchetti F, Young D, London SN (1996) Numerical and structural chromosome aberrations induced by etoposide (VP-16) during oocyte maturation of mice: transmission to one-cell zygotes and damage to dictyate oocytes. Mutagenesis 11:357-361
25. Marchetti F, Pearson FS, Bishop JB, Wyrobek AJ (2006) Etoposide induces chromosomal abnormalities in mouse spermatocytes and stem cell spermatogonia. Hum Reprod 21(4):888-895
26. Muindi JF, Stevens YW, Warrell RP Jr, Young CW (1993) In vitro diVerential metabolism of merbarone by xanthine oxidase and microsomal Xavoenzymes. The role of reactive oxygen species. Drug Metab Dispos 21(3):410-414
27. Neuwelt EA, Pagel MA, Kraemer DF, Peterson DR, Muldoon LL (2004) Bone marrow chemoprotection without compromise of chemotherapy eYcacy in a rat brain tumor model. J Pharmacol Exp Ther 309(2):594-599
28. Russell LB, Hunsicker PR, Johnson DK, Shelby MD (1998) Unlike other chemicals, etoposide (a topoisomerase-II inhibitor) produces peak mutagenicity in primary spermatocytes of the mouse. Mutat Res 400(1-2):279-286
29. SkouWas DA, Lacroix FB, Andreassen PR, Wilson L, Margolis RL (2004) Inhibition of DNA decatenation, but not DNA damage, arrests cells at metaphase. Mol Cell 15(6):977-990
30. Tateno H, Kamiguchi Y (2001) Meiotic stage-dependent induction of chromosome aberrations in Chinese hamster primary oocytes exposed to topoisomerase II inhibitor etoposide. Mutat Res 476:139-148
31. Wang L, Eastmond DA (2002) Catalytic inhibitors of topoisomerase II are DNAdamaging agents: induction of chromosomal damage by merbarone and ICRF-187. Environ Mol Mutagen 39(4):348-356